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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Experimental study on the influence of temperature cycle on low-rank coal permeability显示文摘The formation temperature is a key factor affecting coalbed methane(CBM)migration in reservoirs.Both the prediction of CBM production and prevention of mine gas disasters require the understanding on the controlling mechanism of temperature on coal permeability.We experimentally examined the evolution of permeability for natural low-rank coal samples under various stresses and cyclic temperature conditions.Apparent permeability and intrinsic permeability decrease significantly when the temperature increases and they only partially recover after the temperature returns.The permeability loss decreases greatly with the increasing number of temperature cycles.The permeability loss due to the rising temperature and the irreversible permeability loss for a whole temperature cycle decrease prominently with increasing confining stress.The impacts of swelling/shrinking of coal matrix,roughness of surface,pore compressibility and weakly bound water in coal on temperature sensitivity of coal permeability are investigated. | ZOU JunPeng JIAO YuYong RATHNAWEERA T D WANG Hao | 2020 | Science China(Technological Sciences)2020，63，6： | 2 |
| 3 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 4 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 5 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 6 | Toughening modification of PS with n-BA/MMA/styrene coreshell structured copolymer from emulsifier-free emulsion polymerization 显示文摘 | Guo T Y Tang G L Hao G J | 2003 | Journal of Applied Science2003，90，： | 1 |
| 7 | Increased endoplasmic reticu-lum stress in atherosclerotic plaques associated with acute coronarysyndrome 显示文摘 | Myoishi M Hao H Minamino T | 2007 | Circulation2007，116，11： | 1 |
| 8 | Origin of the Miocene- Pliocene red-earth formation at Xifeng in northern China and implications for paleoenvironments 显示文摘 | Guo Z T Peng S Z Hao Q Z | 2001 | Palaeogeography Palaeoclimatology Palaeoecology2001，170，： | 1 |
| 9 | A novel optimiza- tion means of transfer efficiency for resonance coupled wirelesspower transfer显示文摘 | LINLIN T HAO Q XUELIANG H | 2013 | Telkomnika2013，11，5： | 1 |
| 10 | Spatial variations of magnetic susceptibility of Chinese loess for the last 600 kyr: Implications for monsoon evolution显示文摘 | Hao Q Z Guo Z T | 2005 | Journal of Geophysical Research2005，110，12： | 1 |
| 11 | Rapid identification ofophiopogonins and ophiopogonones in Ophiopogon japonicus extract with a practical technique of mass defect filtering based on high resolution mass spectrometry 显示文摘 | Xie T Liang Y Hao H | 2012 | J Chromatogr A2012，1227，： | 1 |
| 12 | Towards a proteome -scale map of the human protein-protein interaction network 显示文摘 | Rual JF Venkatesan K Hao T | 2005 | Nature2005，437，7062： | 1 |
| 13 | Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions显示文摘 | Hao X P Willis J E Pretlow T G | 2000 | Cancer Res2000，60，1： | 1 |
| 14 | Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response显示文摘 | PENG T HAO L MADRI JA | 2005 | J Clin Inverst2005，115，： | 1 |
| 15 | Onset of Asian desertification by 22 Myr ago inferred from loess deposits in China显示文摘 | Guo Z T Ruddiman W F Hao Q Z | 2002 | Nature2002，416，： | 1 |
| 16 | Abnormal organic matter maturation in the Yinggehai Basin,offshore South China Sea:Implications for hydrocarbon expulsion and fluid migration from overpressured systems显示文摘 | Hao F Li S T Dong W L | 1998 | Journal of Petroleum Geology1998，21，4： | 1 |
| 17 | Towards a proteomescale map of the human protein-protein interaction network显示文摘 | Rual JF Venkatesan K Hao T | 2005 | Nature2005，437，： | 1 |
| 18 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 19 | Geochemical evidence for the provenance of middle Pleistocene loess deposits in southern China 显示文摘 | Hao Q Z Guo Z T Qiao Y S | 2010 | Quaternary Science Reviews2010，29，： | 1 |
| 20 | Trans-upper-sternal approach to the cervicothoracic junction 显示文摘 | Liu YL Hao YJ Li T | 2009 | Clin Orthop Relat Res2009，467，： | 1 |
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