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| 1 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 2 | Polymer mierocapsules by interfacial polyaddition between styrene-maleic anhydride copolymers and amines显示文摘 | Harald D H Stover | 2002 | Journal of Membrane Science2002，209，2： | 1 |
| 3 | Polymer microcapsules by interfacial polyaddition between styrene-maleic anhydride copolymers and amines显示文摘 | Anna S Harald D | 2002 | Journal of Membrane Science2002，209，： | 1 |
| 4 | Growth mechanism of poly(divinylbenzene) microspheres in precipitation polymerization显示文摘 | Jeffrey S D Li W H Harald D H | 1999 | Macromolecules1999，32，： | 1 |
| 5 | Interventional MRA and intravascular imaging显示文摘 | Mare E L Harald H Q Jorg F D | 2000 | JMRI2000，12，： | 1 |
| 6 | The value of serologic markers in indeterminate colitis: A prospective follow-up study显示文摘 | Sofie Joossens Walter Reinisch Séverine Vermeire Boualem Sendid Daniel Poulain Marc Peeters Karel Geboes Xavier Bossuyt Peggy Vandewalle Georg Oberhuber Harald Vogelsang Paul Rutgeerts Jean-Frédéric Colombel | 2002 | Gastroenterology2002，，： | 1 |
| 7 | Predicting failure of bonded patches using a fracture mechanics approach 显示文摘 | Harald O McGeorge D | 2012 | International Journal of Adhesion and Adhesives2012，37，： | 1 |
| 8 | Urinary proteomics in diabetes and CKD显示文摘 | KASPER R HARALD M MOHAMMED D | 2008 | J Am Soc Nephrol2008，19，： | 1 |
| 9 | The concept of joint production and ecological economics显示文摘 | STEFAN B HARALD D MALTE F | 2001 | Ecological Eco- nomics2001，36，3： | 1 |
| 10 | Polymer Microcapsules by Interracial Polyaddition between Styrene Maleic Anhydride Copolymers and Amines 显示文摘 | Anna S Harald D S | 2002 | Journal of Membrane Science2002，209，2： | 1 |
| 11 | Iron and sulphur isotopes from the Carajás mining province (Pará, Brazil): Implications for the oxidation of the ocean and the atmosphere across the Archaean–Proterozoic transition显示文摘 | Sébastien Fabre Anne Nédélec Franck Poitrasson Harald Strauss Christophe Thomazo Afonso Nogueira | 2011 | Chemical Geology2011，，1： | 1 |
| 12 | Design of California Aqueduct显示文摘 | Harald D Frederiksen | 1968 | Journal of Irrigation and Drainage Engineering1968，95，2： | 1 |
| 13 | The impact of social support and sense of coherence on health-related quality of life among nursing home residents : a questionnaire survey in Bergen, Norway 显示文摘 | Jorunn D Geir Egil E Harald A | 2009 | Inter J Nurs Stu2009，46，1： | 1 |
| 14 | Hodgkin's lymphoma: biology and treatment strategies for primary, refractory, and relapsed disease 显示文摘 | Volker D Harald S Michael H | 2003 | Hematology (Am Soc Hematol Educ Program)2003，，： | 1 |
| 15 | Combined Procrustes analysis and PLSR for internal and external mapping of data from multiple sources 显示文摘 | Garmt D Harald M Magni M | 2005 | Computational Statistics and Data Analysis2005，48，1： | 1 |
| 16 | Characterization of mtDNA SNP typing and mixture ratio assessment with simultaneous real-time PCR quantification of both allelic states 显示文摘 | Harald N Michael D C Petra G | 2006 | Int J Leg Med2006，120，： | 1 |
| 17 | An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii 显示文摘 | Lenie D Alexandr N Harald S | 2007 | Nature Reviews Microbiology2007，5，12： | 1 |
| 18 | An increasing threat in hospitals:muhidmg-resistant Acinetobacter baumannii显示文摘 | Lenie D Alexandr N Harald S | 2007 | Nat Rev Microbiol2007，5，12： | 1 |
| 19 | Water crisis in developing world:misconceptions about solutions显示文摘 | Harald D F | 1996 | J of Water Resources Planning and Management1996，，2： | 1 |
| 20 | Wages,fringe benefits and worker turnover显示文摘 | HARALD D O | 2006 | Labor Economics2006，13，1： | 1 |
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