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| 1 | A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties 显示文摘 | Ali S S Hardt J I Quick K L Kim-Han J S Erlanger B F H uang T T | 2004 | Free Radic Biol Med2004，37，： | 1 |
| 2 | Teaching non-technical skills for critical incidents: Crisis resource management training for medical students显示文摘 | Krtiger A Gillmann B Hardt C | 2009 | Anaesthesist2009，58，6： | 1 |
| 3 | A model of full penetration arc-welding for control system design 显示文摘 | HARDT D E GARLOW D A WEINERT J B | 1985 | Journal of Dynamic Systems Measurement and Control1985，107，： | 1 |
| 4 | Effects of processing parameters on the micro-channels replication in microfluidic devices fabricated by micro injection molding显示文摘 | FuG Tor S B Hardt D E | 2011 | Microsystem Technologies2011，17，12： | 1 |
| 5 | 人乳头瘤病毒16/18型AS04佐剂疫苗预防肿瘤基因型HPV引起的宫颈感染和癌前病变的效应(PATRICIA):一项在年轻女性中进行的双盲、随机研究的最终分析显示文摘背景在年轻成人中进行的Ⅲ期随机、双盲对照PATRICIA试验(PApilloma TRial)的事件驱动期中分析显示,人乳头瘤病毒(HPV)16/18AS04佐剂疫苗具有免疫原性,且总体耐受性良好,对HPV16或HPV18感染及相关的癌前病变具有预防效应。本文作者旨在评估最终事件驱动分析中的疫苗效应。方法将在基线、1个月和6个月接种疫苗的15~25岁女性分类为符合方案的效应队列(ATP-E队列;疫苗组8093例,对照组8069例)、总接种队列(TVC;包括至少接种1剂疫苗的所有女性,而不考虑其基线HPV状态;代表普遍的年轻女性人群,包括性活跃者;疫苗组9319例,对照组9325例)和TVC-naive(无证据表明基线时存在肿瘤基因型HPV感染;代表无性行为女性;疫苗组5822例,对照组5819例)。主要终点是。在基线时血清和DNA均为阴性且在6个月时为相应类型(ATP-E队列)的女性中,评估疫苗对HPV16或HPV18相关性宫颈上皮内瘤变≥2级(CIN2+)的预防效应。该试验在ClinicalTrial.gov上的注册编码为NCT00122681.结果第3剂疫苗接种后平均随访34.9个月(s=6.4)。在主要分析中疫苗对HPV16/18相关性CIN2+的预防效应为92.9%(96.1%CI79.9%~98.3%),在对可能因多种肿瘤基因型HPV引起的病变(ATP-E队列)的分析中,其预防效应为98.1%(96.1%CI88.4%~100%)。不考虑病变HPVDNA时,疫苗对CIN2+的预防效应在TVC中为30.4%(96.1%CI16.4%~42.1%),在TVC-naive中为70.2%(96.1%CI54.7%~80.9%);而对CIN3+的相应效应在TVC中为33.4%(96.1%CI9.1%~51.5%).在TVC-naive中为87.0%(96.1%CI54.9%~97.7%).在预防12种非疫苗肿瘤基因型HPv相关性CIN2+的效应为54.0%(96.1%CI34.0%~68.4%:ATP-E队列)。在TVC中可见对HPV31、33和45相关性CIN2+的个体交叉保护效应。结论HPV16/18 AS04佐剂疫苗表现出对HPV16/18和非疫苗肿瘤基因型HPV相关性CIN2+较强的预防效应,而要获得整体预防效应就需要在更广泛的人群中进行大面积强化免疫计划。基金 葛兰素史克。 | J Paavonen P Naud J Salmeron C M Wheeler S-N Chow D Apter H Kitchener X Castellsague J C Teixeira S R Skinner J Hedrick U Jaisamrarn G Limson S Garland A Szarewski B Romanowski F Y Aoki T F Schwarz W A J Poppe F X Bosch D Jenkins K Hardt T Zahaf D Descamps F Struyf M Lehtinen G Dubin 周彩虹(译) | 2009 | 世界临床医学2009，，12： | 1 |
| 6 | CTF determinationofimages of ice embedded single particles using a graphics interface显示文摘 | Zhou Z H Hardt S Wang B Sherman M B Jakana J Chiu W | 1996 | Journal ofStructural Biology1996，116，21： | 1 |
| 7 | Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: a pooled analysis of 11 clinical trials 显示文摘 | Descamps D Hardt K Spiessens B | 2009 | Hum Vaccin2009，5，5： | 1 |
| 8 | A high-resolution stalagmite record of the Holocene East Asian monsoon from Mt Shennogjia, central China显示文摘 | DONG J G WANG Y J CHENG H HARDT B EDWARDS R 1 KONG X ZHAO K | 2010 | The Holocene2010，20，2： | 1 |
| 9 | Teaching non-technical skills for critical incidents: Crisis resource management training for medical students显示文摘 | Kruger A Gillmann B Hardt C | 2009 | Anaesthesist2009，58，6： | 1 |
| 10 | Mechanisms Controlling Pathogen Colonization of the Gut显示文摘 | STECHER B HARDT W D | 2011 | Current Opinion in Microbiology2011，14，1： | 1 |
| 11 | The role of microbiota in infectious disease 显示文摘 | STECHER B HARDT W D | 2008 | Trends Microbio12008，16，3： | 1 |
| 12 | Laser - induced transfer of metallic nanodroplets for plasmonics and metamaterial applications 显示文摘 | Arseniy I Kuznetsov Andrey B Evlyukhin Carsten Rein- hardt | 2009 | J Opt Soc Am2009，26，12： | 1 |
| 13 | The TIME technique: A new method for locai-zed alveolar ridge augmentation prior to placement of dental implants 显示文摘 | von Arx T Hardt N Wallkamm B | 1996 | Int J Or-aaxillofac hnplants1996，11，： | 1 |
| 14 | Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening显示文摘 | Hardt PD Toepler M Ngoumou B | 2003 | Anticancer Res2003，23，2： | 1 |
| 15 | Blooming' in the gut: how dysbio- sis might contribute to pathogen evolution 显示文摘 | Stecher B Maier L Hardt WD | 2013 | Nat Rev Microbiol2013，11，4： | 1 |
| 16 | The role of microbiota in infectious disease显示文摘 | Stecher B Hardt W D | 2008 | Trends Microbiol2008，16，3： | 1 |
| 17 | The role of microbiota in infectious disease显示文摘 | STECHER B HARDT W D | 2008 | Trends in Microbiology2008，16，3： | 1 |
| 18 | Measurement of fecal pyruvate kinase type M2(tumor M2-PK)concentrations in patients with gastric cancer,colorectal cancer,colorectal adenomas and controls显示文摘 | Hardt PD Toepler M Ngoumou B | | 0，，： | 1 |
| 19 | Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention:a pooled analysis of 11 clinical trials显示文摘 | Descamps D Hardt K Spiessens B | | 0，，05： | 1 |
| 20 | The seasonality of East central North American precipitation based on three coeval Holocene speleothems from southern West Virginia 显示文摘 | Hardt B Rowe H D Springer G S | 2010 | Earth and Planetary Science Letters2010，295，： | 1 |
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