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| 1 | 17β-estradiol attenuates homocysteine-induced oxidative stress and inflammatory response as well as MAPKs cascade via activating PI3-K/Akt signal transduction pathway in Raw 264,7 cells显示文摘氧化应力,煽动性的反应,和激活 mitogen 的蛋白质 kinases (MAPK ) 串联是骨质疏松症的重要病原的因素。提高的 homocysteine (Hcy ) 可以在绝经后的骨质疏松症激活氧化应力和还原剂骨头矿物质密度,这被报导了。而且,荷尔蒙代替治疗广泛地在诊所被使用了与骨质疏松症阻止并且对待绝经后的女人, osteoporotic 骨折和位于 Hcy 的行动下面的相关信号 transduction 小径仍然保持不清楚。在这研究,我们调查了 17-estradiol 的效果(导致 Hcy 的氧化压力,煽动性的反应和 MAPK 串联,以及内在的信号 transduction 小径在上的 17-E 2) 鼠科未加工 264.7 个房间。反应的氧种类(ROS ) 被 fluorospectrophotometry 估计。proinflammatory cytokines 肿瘤坏死因素 --(TNF-) 并且 interleukin (IL )-1 被 double-immunofluorescence 标记和反向的 transcriptase 聚合酶链反应试金分析分别地。而且, MAPK 串联的 phosphorylation 层次被西方的污点分析测量。一个特定的 phosphatidylinositol 3-kinase (PI3-K ) 禁止者, Wortmannin (1 M ) 被采用决定 PI3-K/Akt 发信号小径是否调停了 17-E 2 的效果在上未加工 264.7 个房间。17-E 2 显著地减少了 ROS 生产由 Hcy 导致了,在蛋白质和 mRNA 的 TNF-1 和 IL-1 的表示铺平,并且下面调整 MAPK (ERK1/2, JNK 和 p38 ) 的 phosphorylation。导致 Hcy 的变化上的 17-E 2 的这些压制的效果被预告的处理与 PI3-K 禁止者 Wortmannin 颠倒。结果显示那 17-estradiol 可以稀释 MAPK 的导致 Hcy 的氧化应力,煽动性的反应和起来规定在未加工经由 PI3-K/Akt 的 264.7 个房间表明 transduction 小径。 | Ying Zhang Ying He Yi Zong Jiazhi Guo Lin Sun Yunbing Ma Wei Dong Li Gui | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 9 |
| 2 | Two-photon AIE probe conjugated theranostic nanoparticles for tumor bioimaging and pH-sensitive drug delivery显示文摘Nanoparticles armed with chemotherapy drug and fluorescence probe have become an effective anticancer strategy for their advantages in cancer diagnosis and treatment.However,fluorophore for diagnostic medicine with deep penetration depth and high resolution are still very rare,while rational designs are also required to improve the tumor retention and target-site drug delivery.Herein,a two-photon fluorophore with aggregation-induced emission and large two-photon absorption cross-section has been designed for two-photon bioimaging,and a novel theranostic nanoplatform is also constructed based on doxorubicin and the two-photon fluorophore conjugated copolymer,P(TPMA-co-AEMA)-PEI(DA)-Blink-PEG (PAEEBlink-DA).The micelles maintain a “stealth” property during blood circulation and is activated in the acidic tumor microenvironment,which triggers the charge-conversion and results in enhanced micellar internalization.Meanwhile,PAEMA chains can convert from hydrophobicity to hydrophilicity with accelerated drug release and particle size expansion.The enlarged particle size would potentially extend the retention time of these micelles.Moreover,a great AIE active two-photon bioimaging with tissue penetration depth up to 150 μm is observed and the in vivo biodistribution of nanoparticles can be traced.The in vivo antitumor results further indicate the obvious reduction of adverse effect and enhanced treatment effect of these micelles,proving that these PAEEBlink-DA micelles would be a potential candidate for tumor theranostic applications. | Boxuan Ma Weihua Zhuang Haiyang He Xin Su Tao Yu Jun Hu Li Yang Gaocan Li Yunbing Wang | 2019 | Nano Research2019，12，7： | 2 |
| 3 | Catalytic oxidation of the dye wastewater with hydrogen peroxide显示文摘 | Qiu Zumin He Yunbing Liu Xiaocheng | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
| 4 | Catalytic oxidation of the dye wastewater with hydrogen peroxide显示文摘 | Qiu Zumin He Yunbing Liu Xiaocheng | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
| 5 | Catalytic oxidation of the dye wastewater with hydrogen peroxide显示文摘 | Qiu Zumin He Yunbing Liu Xiaocheng | 2005 | Chemical Engineering and Processing2005，44，9： | 1 |
| 6 | In situ DRIFTS study on the catalytic oxidation of toluene over V2O5/TiO2 under mild conditions 显示文摘 | He Yunbing Rui Zebao Ji Hongbing | 2011 | Catalysis Communications2011，12，5： | 1 |
| 7 | Low-temperature utilization of CO_2 and CH_4 by combining partial oxidation with reforming of methane over Ru-based catalysts显示文摘Combination of partial oxidation of methane (POM) with carbon dioxide reforming of methane (CRM) has been studied over Ru-based catalysts at 550℃.POM,CRM and combined reaction were performed over 8wt%Ru/γ-Al2O 3 and the results show that both POM and CRM contribute to the combined reaction,between which POM plays a more important role.Moreover,the addition of Ce to Ru-based catalyst results in an improvement in the activity and CO selectivity under the adopted reaction conditions.The Ce-doped catalyst was characterized by N2 adsorption-desorption,SEM,XRD,TPR,XPS and in situ DRIFTS.The mechanism has been studied by in situ DRIFTS together with the temperature distribution of catalyst bed.The mechanism of the combined reaction is more complicated and it is the combination of POM and CRM mechanisms in nature.The present paper provides a new catalytic system to activate CH4 and CO2 at a rather low temperature. | Hongbing Ji Danyan Feng Yunbing He | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 1 |
| 8 | Palladium nanoclusters entrapped in polyurea:A recyclable and efficient catalyst for reduction of nitro-benzenes and hydrodechlorination of halogeno-benzenes显示文摘Polyurea-entrapped palladium nanoclusters have been prepared by interfacial polymerization in W/O emulsion and showed high thermal stability and chemical stability with the content of 0.12 mmol g-1 Pd.This catalyst exhibited dual catalytic activity for reduction of nitro compounds and hydrodehalogenation of aromatic chlorides in atmospheric hydrogen with 100% yield for reduction of nitro compounds and >99% yield for hydrodehalogenation of aromatic chlorides.This immobilizing method was particularly effective and eliminated the need of special chelating groups. | JI HongBing LONG QingPing HE YunBing YAO XingDong | 2010 | Science China Chemistry2010，53，7： | 1 |
| 9 | Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation显示文摘Joint contracture is a fibrotic complication induced by joint immobilization and trauma,which is characterized as excessive myofibroblast proliferation in joint capsule.The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction.Our previous study has shown that curcumin can inhibit myofibroblast proliferation in vitro,but the major challenge is the low aqueous solubility and biological activity of curcumin.In this study,hyaluronic acid-curcumin(HA-Cur)conjugate was synthesized to suppress myofibroblasts in joint contracture.Cells were isolated from the joint capsules of joint contracture patients and induced to active myofibroblasts by transforming growth factor-b(TGF-b).The anti-fibrotic function and mechanisms of HA-Cur were investigated by immunohistochemistry,reverse transcription-quantitative polymerase chain reaction(PCR),methylation-specific PCR,western blot,transwell migration assay and proliferation assay.Results showed that 30 lM HA-Cur significantly attenuated the fibrotic functions of myofibroblast in joint contracture in vitro by regulating the methylation of prostaglandin E receptor 2(PTGER2)and inhibiting TGF-b signaling.This may provide a mechanism for the treatment of joint contracture,and provide a molecular target PTGER2 for therapy during the pathogenesis of joint contracture. | Dongjie Yu Ze Zhuang Jianhua Ren Xuefeng Hu Zhe Wang Jieyu Zhang Yuansen Luo Kun Wang Ronghan He Yunbing Wang | 2019 | Regenerative Biomaterials2019，6，5： | 1 |
| 10 | Hierarchical Capillary Coating to Biofunctionlize Drug-Eluting Stent for Improving Endothelium Regeneration显示文摘The drug-eluting stent(DES)has become one of the most successful and important medical devices for coronary heart disease,but yet suffers from insufficient endothelial cell(EC)growth and intima repair,eventually leading to treatment failure.Although biomacromolecules such as vascular endothelial growth factor(VEGF)would be promising to promote the intima regeneration,combining hydrophilic and vulnerable biomacromolecules with hydrophobic drugs as well as preserving the bioactivity after harsh treatments pose a huge challenge.Here,we report on a design of hierarchical capillary coating,which composes a base solid region and a top microporous region for incorporating rapamycin and VEGF,respectively.The top spongy region can guarantee the efficient,safe,and controllable loading of VEGF up to 1μg/cm^(2) in 1 minute,providing a distinctive real-time loading capacity for saving the bioactivity.Based on this,we demonstrate that our rapamycin-VEGF hierarchical coating impressively promoted the competitive growth of endothelial cells over smooth muscle cells(ratio of EC/SMC~25)while relieving the adverse impact of rapamycin to ECs.We further conducted the real-time loading of VEGF on stents and demonstrate that the hierarchical combination of rapamycin and VEGF showed remarkable endothelium regeneration while maintaining a very low level of in-stent restenosis.This work paves an avenue for the combination of both hydrophobic and hydrophilic functional molecules,which should benefit the next generation of DES and may extend applications to diversified combination medical devices. | Jing Wang Yunfan Xue Jun Liu Mi Hu He Zhang Kefeng Ren Yunbing Wang Jian Ji | 2020 | Research2020，，1： | 1 |
| 11 | Towards prediction of ordered phases in rechargeable battery chemistry via group–subgroup transformation显示文摘The electrochemical thermodynamic and kinetic characteristics of rechargeable batteries are critically influenced by the ordering of mobile ions in electrodes or solid electrolytes.However,because of the experimental difficulty of capturing the lighter migration ion coupled with the theoretical limitation of searching for ordered phases in a constrained cell,predicting stable ordered phases involving cell transformations or at extremely dilute concentrations remains challenging.Here,a group-subgroup transformation method based on lattice transformation and Wyckoff-position splitting is employed to predict the ordered ground states.We reproduce the previously reported Li_(0.75)CoO_(2),Li_(0.8333)CoO_(2),and Li_(0.8571)CoO_(2)phases and report a new Li_(0.875)CoO_(2)ground state.Taking the advantage of Wyckoff-position splitting in reducing the number of configurations,we identify the stablest Li_(0.0625)C_(6) dilute phase in Li-ion intercalated graphite.We also resolve the Li/La/vacancy ordering in Li_(3x)La_(2/3−x)TiO_(3)(0 | Yunbing Ran Zheyi Zou Bo Liu Da Wang Bowei Pu Penghui Mi Wei Shi Yajie Li Bing He Ziheng Lu Xia Lu Baihai Li Siqi Shi | 2021 | npj Computational Materials2021，，1： | 1 |
| 12 | Author Correction: Towards prediction of ordered phases in rechargeable battery chemistry via group-subgroup transformation显示文摘The original version of this Article contained error in DATA AVAILABILITY,in which the website hyperlink is not valid and should be revised to https://github.com/shuhebing/gsop.The same error also occurs in CODE AVAILABILITY,in which the website hyperlink should also be revised to https://github.com/shuhebing/gsop. | Yunbing Ran Zheyi Zou Bo Liu Da Wang Bowei Pu Penghui Mi Wei Shi Yajie Li Bing He Ziheng Lu Xia Lu Baihai Li Siqi Shi | 2022 | npj Computational Materials2022，，1： | 0 |
| 13 | Deep oxidation in propane oxidative dehydrogenation to propene over V_2O_5/γ-Al_2O_3 studied by in-situ DRIFTS显示文摘In-situ DRIFTS was used to study the deep oxidation of propane,a side reaction during propane oxidative dehydrogenation to propene.Strong adsorption of propene was supposed to be the main reason for the deep oxidation.It was found that gaseous oxygen in the feed and the reaction temperature had great influence on the reaction.To obtain a relative high selectivity to propene,the reaction temperature should be maintained at 150~250 ℃ with a proper content of gaseous oxygen in the feed for a certain catalyst and some modifiers which could weaken the adsorption of propene on the catalyst surface would be favorable. | Yunbing He Hongbing Ji Jianhua Xu Lefu Wang | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 0 |
| 14 | Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells显示文摘Magnesium alloy(Mg alloy)has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability.However,whether and how the Mg alloy induces inflammation in endothelial cells remains unclear.In the present work,we investigated the activation of Yes-associated protein(YAP)upon Mg alloy stimuli and unveiled the transcriptional function in Mg alloy-induced inflammation.Quantitative RT–PCR,western blotting and immunofluorescence staining showed that Mg alloy inhibited the Hippo pathway to facilitate nuclear shuttling and activation of YAP in human coronary artery endothelial cells(HCAECs).Chromatin immunoprecipitation followed sequencing was carried out to explore the transcriptional function of YAP in Mg alloy-derived inflammation.This led to the observation that nuclear YAP further bonded to the promoter region of inflammation transcription factors and co-transcription factors.This binding event activated their transcription and modified mRNA methylation of inflammation-related genes through regulating the expression of N6-methyladenosine modulators(METTL3,METTL14,FTO and WTAP).This then promoted inflammation-related gene expression and aggravated inflammation in HCAECs.In YAP deficiency cells,Mg alloy-induced inflammation was reduced.Collectively,our data suggest that YAP contributes to the Mg alloy-derived inflammation in HCAECs and may provide a potential therapeutic target that alleviates inflammation after Mg alloy stent implantation. | Hongchi Yu Zhe Hou Nuoya Chen Rifang Luo Li Yang Michael Miao Xiaoyi Ma Lifeng Zhou Fugui He Yang Shen Xiaoheng Liu Yunbing Wang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 15 | 人乳头瘤病毒衣壳蛋白C末端结构臂具有免疫原性并参与病毒-宿主细胞的相互作用显示文摘宫颈癌是全球女性第二大常见恶性肿瘤,人乳头瘤病毒(HPV)是导致女性宫颈癌发生的主要原因。HPV型别众多,主要的高危型型别种类多达15种,且型别间免疫血清交叉保护能力极低,目前国际上已上市的预防性多价HPV疫苗均不能为接种者提供完全保护。 | Zhihai Li Xiaodong Yan Hai Yu Daning Wang Shuo Song Yunbing Li Maozhou He Qiyang Hong Qingbing Zheng Qinjian Zhao Ying Gu Jun Zhang Mandy E.W.Janssen Giovanni Cardone Norman H.Olson Timothy S.Baker 李少伟 Ningshao Xia | 2017 | 科学新闻2017，19，4： | 0 |
| 16 | The biological responses and mechanisms of endothelial cells to magnesium alloy显示文摘Due to its good biocompatibility and degradability,magnesium alloy(Mg alloy)has shown great promise in cardiovascular stent applications.Rapid stent re-endothelialization is derived from migrated and adhered endothelial cells(ECs),which is an effective way to reduce late thrombosis and inhibit hyperplasia.However,fundamental questions regarding Mg alloy affecting migration and adhesion of ECs are not fully understood.Here,we evaluated the effects of Mg alloy on the ECs proliferation,adhesion and migration.A global gene expression profiling of ECs co-culturing with Mg alloy was conducted,and the adhesion-and migration-related genes were examined.We found that Mg alloy had no adverse effects on ECs viability but significantly affected ECs migration and adhesion.Co-cultured with Mg alloy extract,ECs showed contractive adhesion morphology and decreased motility,which was supported by the down-regulation of adhesion-related genes(Paxillin and Vinculin)and migration-related genes(RAC 1,Rho A and CDC 42).Accordingly,the re-endothelialization of Mg alloy stent was inhibited in vivo.Our results may provide new inspiration for improving the broad application of Mg alloy stents. | Zhe Hou Maolong Xiang Nuoya Chen Xiao Cai Bo Zhang Rifang Luo Li Yang Xiaoyi Ma Lifeng Zhou Fugui He Hongchi Yu Yunbing Wang | 2021 | Regenerative Biomaterials2021，8，3： | 0 |
| 17 | A chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane显示文摘Erianthus produces substantial biomass,exhibits a good Brix value,and shows wide environmental adaptability,making it a potential biofuel plant.In contrast to closely related sorghum and sugarcane,Erianthus can grow in degraded soils,thus releasing pressure on agricultural lands used for biofuel production.However,the lack of genomic resources for Erianthus hinders its genetic improvement,thus limiting its potential for biofuel production.In the present study,we generated a chromosome-scale reference genome for Erianthus fulvus Nees.The genome size estimated by flow cytometry was 937 Mb,and the assembled genome size was 902 Mb,covering 96.26%of the estimated genome size.A total of 35065 proteincoding genes were predicted,and 67.89%of the genome was found to be repetitive.A recent wholegenome duplication occurred approximately 74.10 million years ago in the E.fulvus genome.Phylogenetic analysis showed that E.fulvus is evolutionarily closer to S.spontaneum and diverged after S.bicolor.Three of the 10 chromosomes of E.fulvus formed through rearrangements of ancestral chromosomes.Phylogenetic reconstruction of the Saccharum complex revealed a polyphyletic origin of the complex and a sister relationship of E.fulvus with Saccharum sp.,excluding S.arundinaceum.On the basis of the four amino acid residues that provide substrate specificity,the E.fulvus SWEET proteins were classified as monoand disaccharide sugar transporters.Ortho-QTL genes identified for 10 biofuel-related traits may aid in the rapid screening of E.fulvus populations to enhance breeding programs for improved biofuel production.The results of this study provide valuable insights for breeding programs aimed at improving biofuel production in E.fulvus and enhancing sugarcane introgression programs. | Ling Kui Aasim Majeed Xianhong Wang Zijiang Yang Jian Chen Lilian He Yining Di Xuzhen Li Zhenfeng Qian Yinming Jiao Guoyun Wang Lufeng Liu Rong Xu Shujie Gu Qinghui Yang Shuying Chen Hongbo Lou Yu Meng Linyan Xie Fu Xu Qingqing Shen Amit Singh Karl Gruber Yunbing Pan Tingting Hao Yang Dong Fusheng Li | 2023 | Plant Communications2023，4，4： | 0 |
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