| 2 | Preparation and printability of ultrashort self-assembling peptide nanoparticles显示文摘Nanoparticles(NPs)have left their mark on the field of bioengineering.Fabricated from metallic,magnetic,and metal oxide materials,their applications include drug delivery,bioimaging,and cell labeling.However,as they enter the body,the question remains-where do they go after fulfilling their designated function?As most materials used to produce NPs are not naturally found in the body,they are not biodegradable and may accumulate overtime.There is a lack of comprehensive,long-term studies assessing the biodistribution of non-biodegradable NPs for even the most widely studied NPs.There is a clear need for NPs produced from natural materials capable of degradation in vivo.As peptides exist naturally within the human body,their non-toxic and biocompatible nature comes as no surprise.Ultrashort peptides are aliphatic peptides designed with three to seven amino acids capable of self-assembling into helical fibers within macromolecular structures.Using a microfluidics flow-focusing approach,we produced different peptide-based NPs that were then three-dimensional(3D)printed with our novel printer setup.Herein,we describe the preparation method of NPs from ultrashort self-assembling peptides and their morphology in both manual and 3D-printed hydrogels,thus suggesting that peptide NPs are capable of withstanding the stresses involved in the printing process. | Sarah Ghalayini Hepi Hari Susapto Sophie Hall Kowther Kahin Charlotte A.E.Hauser | 2019 | International Journal of Bioprinting2019，5，2： | 0 |
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