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| 1 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 2 | Physiology of yield determination of rice under elevated carbon dioxide at high temperatures in a subhumid tropical climate显示文摘 | De Costa W A J M Weerakoon W M W Herath H M L K | | 0，，01： | 1 |
| 3 | Prediction of resilient modulus of cohesive subgrade soilsfrom dynamic cone penetrometer test parameters显示文摘 | Mohammad L N Herath A Abu-Farsakh M Y | 2007 | Journal of Materials in Civil Engineering2007，19，11： | 1 |
| 4 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 5 | Assoeiation between smoking, betel chewing and gingival bleeding in rural Sri Lanka 显示文摘 | AMARASENA N EKANAYAKA AN HERATH L | 2003 | J Clin Periodoniol2003，30，5： | 1 |
| 6 | Evaluation of Resilient Modulus of Subgrade Soil by Cone Penetration Test显示文摘 | Mohammad L N Titi H H Herath A | 1999 | Transportation Research Record1999，1，1652： | 1 |
| 7 | Tobacco use and oral hygiene as risk indieators for Peri- odoniitis 显示文摘 | ALNARASENA N EKANAYAKA A N HERATH L | 2002 | Conununity Dent Oral Epidemiol2002，30，2： | 1 |
| 8 | Biological evaluation of solid freeformed,hard tissue scaffolds for orthopedic applications显示文摘 | Herath HM Di Silvio L Evans JR | | 0，，02： | 1 |
| 9 | Antifungal anstituent from gordonia dassanayake 显示文摘 | Athukoralage R S Herath H M T B Wijesundera R L C | 2001 | Fitoterapia2001，72，5： | 1 |
| 10 | Antifungel anstituent from gordonia dassanayake显示文摘 | ATHUKORALAGE R S HERATH H M T B WIJESUNDERA R L C et el | 2001 | Fitoterapia2001，72，5： | 1 |
| 11 | The quality of exogenous organic matter: short-term effects on soil physical properties and soil organic matter fractions显示文摘 | Leroy B L M Herath M S K Sleutel S | 2008 | Soil Use and Management2008，24，： | 1 |
| 12 | A new sesquiterpene lactone from Elephantopus scaber 显示文摘 | De Silva L B Herath W Jennings R C | 1982 | Phytochem1982，21，5： | 1 |
| 13 | A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis显示文摘 | Oak SR Murray L Herath A | | 0，，6： | 1 |
| 14 | p73 is up-regulated in a subset of hepatocellular carcinomas显示文摘 | Herath N I Kew M C Whitehall V L | 2000 | Hepatology2000，31，3： | 1 |
| 15 | Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone(chrysin),and 5-and 6-hydroxyflavones显示文摘 | Herath W Mikell J R Hale A L | 2008 | Chem Pharm Bull2008，56，4： | 1 |
| 16 | Liver disease and therenin-angiotensin system:Recent Discoveries and Clinical im-plications显示文摘 | Lubel J S Herath C B Burrel L M | | 0，，09： | 1 |
| 17 | A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis显示文摘 | Oak SR Murray L Herath A | 2011 | PLoS One2011，6，21： | 1 |
| 18 | A micro RNA processing de- fect in rapidly progressing idiopathic pulmonary fibrosis 显示文摘 | Oak SR Murray L Herath A | 2011 | PLoS One2011，6，21： | 1 |
| 19 | Interphase molecular cytogenetic analysis of epithelial ovarian carcinoma显示文摘 | Persons D L Hartmann L C Herath J F | 1993 | Am J Pothol1993，142，3： | 1 |
| 20 | 查看详情显示文摘 | Hanel R Conrath B Herath L | | 0，，： | 1 |
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