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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | 现代阻燃剂体系及阻燃测试标准显示文摘剖析了火灾产生的过程,概述了纺织工业中常用的阻燃剂体系和阻燃整理耐久性分类,介绍了阻燃产品的部分测试标准。 | Herbert Rsch | 2007 | 印染2007，33，23： | 5 |
| 3 | Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C显示文摘AIM: To assess systematically the spectrum and extent of depressive symptoms comparing patient groups receiving peginterferon or conventional interferon.METHODS: Ninety-eight patients with chronic hepatitis C and interferon-based therapy (+ribavirin) were consecutively enrolled in a longitudinal study. Patients were treated with conventional interferon alfa-2b (48/98patients; 5 MIU interferon alfa-2b thrice weekly) or peginterferon alfa-2b (50/98 patients; 80-150 μgpeginterferon alfa-2b) in combination with weight-adapted ribavirin (800-1 200 mg/d). Repeated psychometric testing was performed before, three times during and once after antiviral therapy: Depression was evaluated by the Hospital Anxiety and Depression Scale (HADS), anger/hostility by the Symptom Checklist-90 Items Revised (SCL-90-R).RESULTS: Therapy with pegylated interferon alfa-2bproduces comparable scores for depression (ANOVA:P = 0.875) as compared to conventional interferon.Maximums of depression scores were even higher and cases of clinically relevant depression were frequent during therapy with peginterferon. Scores for anger/hostility were comparable for both therapy subgroups.CONCLUSION: Our findings suggest that the extent and frequency of depressive symptoms in total are not reduced by peginterferon. Monitoring and management of neuropsychiatric toxicity especially depression have to be considered as much as in antiviral therapy with unmodified interferon. | Michael R Kraus Arne Sch(a|¨)fer Herbert Csef Michael Scheurlen | 2005 | World Journal of Gastroenterology2005，11，12： | 5 |
| 4 | Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia显示文摘 | Nancy Freitag Irene Tirado-González Gabriela Barrientos Florian Herse Victor L. J. L. Thijssen Susanne M. Weedon-Fekj?r Herbert Schulz Gerd Wallukat Burghard F. Klapp Tania Nevers Surendra Sharma Anne Cathrine Staff Ralf Dechend Sandra M. Blois | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 5 | Analysis of colloidal gold methods for labelling proteins显示文摘 | Warchol JB Brelinska R Herbert DC | 1982 | Histochemistry1982，76，4： | 1 |
| 6 | Cultural and sub-cultural comparisons in preferences for natural settings显示文摘 | Kaplan R Herbert E J | 1987 | Landscape and Urban Planning1987，14，： | 1 |
| 7 | The network of psychological variables in patients with diabetes and their importance for quality oflife and metabolic control显示文摘 | Thea S Herbert F | 2002 | Diabetes Care2002，25，1： | 1 |
| 8 | Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal prote- ase, Nvr' 显示文摘 | LA ROCCA S A HERBERT R J CROOKE H | 2005 | Journal of Virology2005，79，11： | 1 |
| 9 | The chemistry of side reactions and byproduct formation in the system NMMO/cellulose(loycell process)显示文摘 | Thomas R Anti E P Herbert S | 2001 | Progress in Polymer Science2001，26，9： | 1 |
| 10 | Identification and quantitation of cysteine in proteins separated by gel electrophoresis显示文摘 | Herbert K R Gooley A A | 1998 | Joumal of Chromatography A1998，813，： | 1 |
| 11 | Scaphoid fractures: diagnosis, classification and therapy 显示文摘 | Krimmer H Schmitt R Herbert T | 2000 | Unfallchirurg2000，103，： | 1 |
| 12 | Animal mod- els in influenza vaccine testing显示文摘 | Van derLaan JW Herberts C Lambkin - Williams R | 2008 | Expert Rev Vaccines2008，7，6： | 1 |
| 13 | A novel arabidopsis-Colletotrichum pathosystem for the molecular dissection of plant-fungal interactions显示文摘 | O'Connell R Herbert C Sreenivasaprasad S | 2004 | Molecular Plant-Microbe Interactions2004，17，3： | 1 |
| 14 | The incidence of vascular dementia in Can- ada:a comparison with Europe and East Asia显示文摘 | Dubois MF Herbert R | 2001 | Neuro-epidemi- ology2001，20，3： | 1 |
| 15 | Acute low back pain: systematic review of its prognosis 显示文摘 | Pengel L H Herbert R D Maher C G | 2003 | BMJ2003，327，7410： | 1 |
| 16 | Journal status显示文摘 | Johan B Marko A R Herbert V S | 2006 | Scientometrics2006，69，3： | 1 |
| 17 | Validation of analytical methods used incleaning validation显示文摘 | Herbert J K Bruce R | 2004 | J Validat Technol2004，10，3： | 1 |
| 18 | Detection of phthalatemetabolites in human amniotic fluid 显示文摘 | Silva M J Reidy J A Herbert A R | 2004 | Bull Environ ContamToxicol2004，72，6： | 1 |
| 19 | Chewing gum for postoperative recovery of gastrointestinal function 显示文摘 | Short V Herbert G Perry R | 2015 | Cochrane Database Syst Rev2015，2，00： | 1 |
| 20 | Thl-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during routine schistosomiasis显示文摘 | Leeto M Herbert DR Marillier R | 2006 | Am J Pathol2006，169，5： | 1 |
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