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| 1 | Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells显示文摘Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat heart cells. Cells collected at day 3 and 10 of the culture were preincubated with autoantibodies against α1-adrenoceptor and angiotensin II AT1-receptor, agonist phenylephrine and angiotensin II, and control IgG. The pretreated cultured cells were stained for selected mast cell markers tryptase, chymase and TNF-α. The cultured cells were also processed for observation with electron microscopy. The autoantibodies-treatment of the 3-day cultured cells caused both increased intensity of immunofluorescence (p < 0.05) and their enlarged diameters of the mast cells when compared to age-matched ones. In contrast, the fluorescence of preincubated 10-day-old mast cells was decreased compared with controls (p < 0.01). In control samples, the fluorescence of 10-day-old mast cells was significantly higher than that of 3-day-old ones (p < 0.001). Results of electron microscopy examination demonstrated there was an increased granulation of treated 3-day-old mast cells, while a degranulation of mast cells at day 10 of application. The results suggest the modulation effect of the autoantibodies against G-protein-coupled receptors on mast cells, indicating a potential functional link between the autoantibodies against G-protein-coupled receptors and the mast cells in progression of heart disease. | Ludmila Okruhlicova Rosemarie Morwinski Wolfgang Schulze Sabine Bartel Peter Weismann Narcisa Tribulova Gerd Wallukat | 2007 | Cellular & Molecular Immunology2007，4，2： | 6 |
| 2 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 3 | Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy显示文摘Background The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCM), find the relation between these changes and prognosis, an d test a practical method to assess the level of myocardial collagen.Methods Left ventricular samples were collected from DCM patients with different prognosis (transplanted group n=8, weaning group n=10) at the time when the LV ADs were implanted and again during cardiac transplantation (n=8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n=6; weaning group n=7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type Ⅰ procollagen (PⅠCP), amino-terminal propeptide of type Ⅰ procollagen (PⅠNP), amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) and type Ⅰ collagen telopeptide (ⅠCTP) were measured by the equilibrium type radioimmunoassay. Results Before LVAD implantation the level of NSC and ISC in th e weaning group was higher but ASC in the transplanted group was lower than in the control s (P<0.05). After LVAD support, the level of total collagen was higher, but ASC was also lower in the transplanted group than in the controls (P<0.05). In comparison of the pre- and po st-LVAD subgroups of the transplanted and weaning groups, all collagen fraction levels before LVAD implantation were lower in the transplanted group than in the weaning group (P<0.05); but this difference disappeared after LVAD support. Comparison of the pre- and post-LVAD subgroups of the transplanted group showed increased le vel of NSC and total collagen after LVAD support. The changes of serum p eptide concentration showed that PⅢNP increased constantly in the transplanted group, but PⅠCP and PⅠNP increased in the weaning group after LVAD implantation. Conclusions The changes in myocardial collagen level as a sign of myocardial interstitial remodeling in DCM are not involved with total collagen b ut invalved with collagen fractions, and they are related to prognosis. The changes of myocardial c ollagen content and serum procollagen peptide after LVAD support can be regarded as an expression of the reverse of maladaptive myocardial interstitial remodeling. | 梁红 Johannes Müller 翁渝国 Gerd Wallukat 付平 林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer | 2004 | Chinese Medical Journal2004，，3： | 3 |
| 4 | Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia显示文摘 | Nancy Freitag Irene Tirado-González Gabriela Barrientos Florian Herse Victor L. J. L. Thijssen Susanne M. Weedon-Fekj?r Herbert Schulz Gerd Wallukat Burghard F. Klapp Tania Nevers Surendra Sharma Anne Cathrine Staff Ralf Dechend Sandra M. Blois | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 5 | Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor显示文摘 | Wallukat G Homuth V Fischer T | 1999 | J Clin Invest1999，103，7： | 1 |
| 6 | The beta-adrenergic receptors显示文摘 | Wallukat G | 2002 | Herz2002，27，7： | 1 |
| 7 | Immunohistochemi- eal locaiization of angiotensin Ⅱ receptors (AT1) in the heart with anti-peptide antibodies showing a positive chronotropic effect 显示文摘 | Fu ML Schulze W Wallukat G | 1998 | Receptors Channels1998，6，： | 1 |
| 8 | Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy 显示文摘 | Muller J Wallukat G Dandel M | 2000 | Circulatinn2000，101，4： | 1 |
| 9 | Agonislic effectsof antipeptide antibodies and autoantibodies directed against adrenergic and cholinergic receptors: absence of desensitiza- tion显示文摘 | Wallukat G Fu ML Magnusson Y | 1996 | Blood Press Suppl1996，3，： | 1 |
| 10 | 显示文摘 | Muller J Wallukat G Dandel M | 2000 | Cirlulation2000，101，： | 1 |
| 11 | Autoantibodies against the β- adrenergic receptor in human myocarditis and dilated cardiomyopathy: β - adrenergic agonism without desensitization显示文摘 | Wallukat G Morwinski M Kowal K | 1991 | Eur Heart J1991，12，： | 1 |
| 12 | Autoimmunity in idiopathic dilated cardiomyopathy characterization of antibodies against the 13-adrenoreceptor with positive chronotropic effect显示文摘 | Magmossott Y Wallukat G Waagstein F | 1994 | Circulation1994，89，18： | 1 |
| 13 | Chronic Chagas' heart disease:a disease on its way to becoming a worldwide health problem:epidemiology,etiopathology,treatment,pathogenesis and laboratory medicine显示文摘 | Munoz-Saravia SG Haberland A Wallukat G | | 0，，01： | 1 |
| 14 | Autoantibod-ies to the Angiotensin Type I Receptor in Response to Placental Is-chemia and Tumor Necrosis Factor a in Pregnant Rats 显示文摘 | Babbette LaMarca Gerd Wallukat Mayte Llinas | 2008 | Hyperten-sion2008，52，6： | 1 |
| 15 | Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption显示文摘 | Wallukat G Reinke P Dorffel WV | 1996 | Int J Cardiol1996，54，2： | 1 |
| 16 | Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effects显示文摘 | Fu HM Matsui S | 1999 | Life Sci1999，64，67： | 1 |
| 17 | Specific removal of β1-adrenergic autoantibodies from patients with idiopathic dilated cardiomyopathy显示文摘 | Muller J Hetzer R | 2002 | N Engl J Med2002，347，22： | 1 |
| 18 | Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes显示文摘 | Wallukat G Morwinski R Magnusson Y | 1992 | Z Kardiol1992，81，4： | 1 |
| 19 | AT1 receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor 显示文摘 | Dechend R Homuth V Wallukat G | 2000 | Circulation2000，23，20： | 1 |
| 20 | Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy显示文摘 | Dorffel WV Felix SB Wallukat G | 1997 | Circulation1997，95，： | 1 |
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