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| 1 | Vasopressors in obstetric anesthesia: A current perspective显示文摘Vasopressors are routinely used to counteract hypotension after neuraxial anesthesia in Obstetrics. The understanding of the mechanism of hypotension and the choice of vasopressor has evolved over the years to a point where phenylephrine has become the preferred vasopressor. Due to the absence of definitive evidence showing absolute clinical benefit of one over the other, especially in emergency and high-risk Cesarean sections, our choice of phenylephrine over the other vasopressors like mephentermine, metaraminol, and ephedrine is guided by indirect evidence on fetalacid-base status. This review article evaluates the present day evidence on the various vasopressors used in obstetric anesthesia today. | Deb Sanjay Nag Devi Prasad Samaddar Abhishek Chatterjee Himanshu Kumar Ankur Dembla | 2015 | World Journal of Clinical Cases2015，3，1： | 15 |
| 2 | MicroRNAs:a new ray of hope for diabetes mellitus显示文摘Diabetes mellitus has become one of the most common chronic diseases,thereby posing a major challenge to global health.Characterized by high levels of blood glucose(hyperglycemia),diabetes usually results from a loss of insulin-producing β-cells in the pancreas,leading to a deficiency of insulin(type 1 diabetes),or loss of insulin sensitivity(type 2 diabetes).Both types of diabetes have serious secondary complications,such as microvascular abnormalities,cardiovascular dysfunction,and kidney failure.Various complex factors,such as genetic and environmental factors,are associated with the pathophysiology of diabetes.Over the past two decades,the role of small,single-stranded noncoding microRNAs in various metabolic disorders,especially diabetes mellitus and its complications,has gained widespread attention in the scientific community.Discovered first as an endogenous regulator of development in the nematode Caenorhabditis elegans,these small RNAs post-transcriptionally suppress mRNA target expression.In this review,we discuss the potential roles of different microRNAs in diabetes and diabetes-related complications. | Munish Kumar Sayantan Nath Himanshu K Prasad G D Sharma Yong Li | 2012 | Protein & Cell2012，3，10： | 14 |
| 3 | Application of response surface methodology(RSM) for optimization of leaching parameters for ash reduction from low-grade coal显示文摘Coal is the world's most abundant energy source because of its abundance and relatively low cost. Due to the scarcity in the supply of high-grade coal, it is necessary to use low-grade coal for fulfilling energy demands of modern civilization. However, due to its high ash and moisture content, low-grade coal exerts the substantial impact on their consumption like pyrolysis, liquefaction, gasification and combustion process. The present research aimed to develop the efficient technique for the production of clean coal by optimizing the operating parameters with the help of response surface methodology. The effect of three independent variables such as hydrofluoric acid(HF) concentration(10–20% by volume), temperature(60–100 °C), and time(90–180 min), for ash reduction from the low-grade coal was investigated. A quadratic model was proposed to correlate the independent variables for maximum ash reduction at the optimum process condition by using central composite design(CCD) method. The study reveals that HF concentration was the most effective parameter for ash reduction in comparison with time and temperature. It may be due to the higher F-statistics value for HF concentration, which effects to large extent of ash reduction. The characterization of coal was evaluated by Fourier transform infrared spectroscopy(FTIR) analysis and Field-emission scanning electron microscopy with energy-dispersive X-ray(FESEMEDX) analysis for confirmation of the ash reduction. | Sushanta Kumar Behera Himanshu Meena Sudipto Chakraborty B.C.Meikap | 2018 | International Journal of Mining Science and Technology2018，28，4： | 9 |
| 4 | A GFP-based bacterial biosensor with chromosomally integrated sensing cassette for quantitative detection of Hg(Ⅱ) in environment显示文摘A mercury biosensor was constructed by integrating biosensor genetic elements into E. coli JM109 chromosome in a single copy number, using the attP/attB recombination mechanism of λ phage. The genetic elements used include a regulatory protein gene (merR) along with operator/promoter (O/P) derived from the mercury resistance operon from pDU1358 plasmid of Serratia marcescens. The expression of reporter gene gfp is also controlled by merR/O/P. Integration of the construct into the chromosome was done to increase the stability and precision of the biosensor. This biosensor could detect Hg(Ⅱ) ions in the concentration range of 100–1700 nmol/L, and manifest the result as the expression of GFP. The GFP expression was significantly different (P 0.05) for each concentration of inducing Hg(Ⅱ) ions in the detection range, which reduces the chances of misinterpretation of results. A model using regression method was also derived for the quantification of the concentration of Hg(Ⅱ) in water samples. | Himanshu Priyadarshi Absar Alam Gireesh-Babu P Rekha Das Pankaj Kishore Shivendra Kumar Aparna Chaudhari | 2012 | Journal of Environmental Sciences2012，24，5： | 6 |
| 5 | HIV/AIDS国家模型促进艾滋病健康教育探索显示文摘目的建立人类免疫缺陷病毒/艾滋病(HIV/AIDS)国家模型,探索基于案例的动态、计算机可视化的HIV/AIDS教育方法。方法根据撒哈拉以南非洲国家的典型数据建立参考模型。根据T21国家模型的基本设计理念,采用系统动力学方法建立HIV/AIDS国家模型,并结合T21国家模型进行人口、社会、经济的系统分析。结果 HIV/AIDS国家模型清晰地模拟了艾滋病50年的传播趋势及其对国家人口、经济和社会的影响。结论 HIV/AIDS国家模型能够直观地反映艾滋病对人口、社会、经济发展的危害,有助于艾滋病健康教育的推进。 | 蔡雨阳 施莉莉 Himanshu Ardawatia Godfried Nortei Nortey 马进 Pal I. Davidsen | 2010 | 上海交通大学学报(医学版)2010，30，8： | 6 |
| 6 | Optimization of micropatterned poly(lactic-coglycolic acid) films for enhancing dorsal root ganglion cell orientation and extension显示文摘Nerve conduits have been a viable alternative to the ‘gold standard' autograft for treating small peripheral nerve gap injuries. However, they often produce inadequate functional recovery outcomes and are ineffective in large gap injuries. Ridge/groove surface micropatterning has been shown to promote neural cell orientation and guide growth. However, optimization of the ratio of ridge/groove parameters to promote orientation and extension for dorsal root ganglion(DRG) cells on poly(lactic-co-glycolic acid)(PLGA) films has not been previously conducted. Photolithography and micro-molding were used to define various combinations of ridge/groove dimensions on PLGA films. The DRG cells obtained from chicken embryos were cultured on micropatterned PLGA films for cell orientation and migration evaluation. Biodegradation of the films occurred during the test period, however, this did not cause deformation or distortion of the micropatterns. Results from the DRG cell orientation test suggest that when the ridge/groove ratio equals 1(ridge/groove width parameters are equal, i.e., 10 μm/10 μm(even)), the degree of alignment depends on the size of the ridges and grooves, when the ratio is smaller than 1(groove controlled) the alignment increases as the ridge size decreases, and when the ratio is larger than 1(ridge controlled), the alignment is reduced as the width of the grooves decreases. The migration rate and neurite extension of DRG neurons were greatest on 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films. Based on the data, the 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films are the optimized ridge/groove surface patterns for the construction of nerve repair devices. | Ching-Wen Li Brett Davis Jill Shea Himanshu Sant Bruce Kent Gale Jayant Agarwal | 2018 | Neural Regeneration Research2018，13，1： | 5 |
| 7 | Role of locking plates in treatment of difficult ununited fractures: a clinical study显示文摘我们在长骨头与锁在长骨头破裂的 10 困难的 nonunions 锁板固定的 plateMethodsRetrospective 评估折断的困难的 ununited 的处理的经验被做的在场的 ObjectiveTo。固定为大腿骨的柄骨折( 3 个病人)用完了锁住的板腿节的 supracondylar 骨折(差距不属于工会)两根前臂骨头(半径和尺骨)的锁骨骨折的骨折胫骨的骨干的肱骨骨折的柄的尺骨骨折的骨折和肱骨的 supracondylar 骨折(一耐心的各个)。五破裂有超过一以前的没有通过的内部固定。一个病人感染了不属于工会它被清创术管理,演员组固定与在六个星期锁板由固定列在后面。七破裂是衰退的二是寡营养的,一个人是 hypertrophic。腓骨的自体移植在 2 种情况和在所有 patientsResultsMinimum 后续使用的肠骨的冠 cancellous 骨头接枝中被使用是 6 月(范围, 6 月到 2.5 年) 。联合的平均时间是 3.4 月(范围 2.5 ~ 6 月) 。任何一个都没与与锁压缩板,过细的软织物解剖,可接受的减小,好固定技术和骨头 grafting 完成稳定性病人让板相关的复杂并发症或手术后的创伤 infections.ConclusionAlong 能帮助在困难的不属于工会的盒子中完成联合。尽管锁住的板不由自己做,保证多骨的联合,我们发现了它是我们为对待困难的破裂 nonunions 的一套设备的另一有用增加。 | Ashok Kumar Himanshu Gupta Chandra Shekhar Yadav Shah Alam Khan Shishir Rastogi | 2013 | Chinese Journal of Traumatology2013，16，1： | 5 |
| 8 | 培养角膜缘上皮移植后穿透性角膜移植术的早期结果显示文摘目的:描述曾行培养角膜缘上皮移植的患者再行穿透性角膜移植(PKP)的早期结果。
方法:对因化学烧伤造成角膜缘干细胞缺乏而行培养的角膜缘上皮移植后又进行穿透性角膜移植术的患者有关人口统计学、原发病因、角膜缘移植类型、眼表稳定性、视力、移植片透明度和并发症方面的资料进行回顾和复习。对受体角膜片组织病理学特征进行研究,重点观察上皮状态。
结果:在患有角膜缘干细胞缺乏而进行培养的角膜缘上皮移植术的125例患者中,15例接受了穿透性角膜移植术(PKP)。角膜缘上皮移植术后(自体移植组n=11,同种异体移植组n=4)平均间隔时间为7个月(范围2—12个月)。同种异体移植组的4例患者均接受了免疫抑制疗法。15只眼中14只眼(93%)获得了含有稳定的角膜上皮的健全的角膜植片。15只眼中14只眼术前最佳矫正视力低于20/200。PKP后平均随访8.3±5.0个月,8只眼最佳矫正视力高于20/60,5只眼最佳矫正视力20/200至20/60。2只眼低于20/200。15只眼中3只眼发生异体角膜植片的排斥反应但被成功治疗。1只眼发生植片排斥的同时发生了青光眼。同种异体角膜缘上皮移植无一例显示排斥表现。
结论:培养的角膜缘上皮移植后,在形成稳定的眼表后行PKP的早期结果是良好的。为了避免排斥反应,培养的同种异体角膜缘上皮移植者行充分的免疫抑制治疗是必需的。角膜同种异体移植能够单独排斥同种异体角膜缘移植物。 | Virender S. Sangwan Himanshu P. Matalia Geeta K. Vemuganti Ghazala Ifihekar Anees Fatima Shashi Singh, Gullapalli N. Rao 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 5 |
| 9 | Inflammation and dry eye disease——where are we?显示文摘The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear dysfunction.It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease.This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed. | Srinivas K Rao Rishi Mohan Nikhil Gokhale Himanshu Matalia Paras Mehta | 2022 | International Journal of Ophthalmology(English edition)2022，15，5： | 4 |
| 10 | Pathogen Recognition by the Innate Immune System显示文摘 | Himanshu Kumar Taro Kawai Shizuo Akira | 2011 | International Reviews of Immunology2011，，1： | 3 |
| 11 | Balancing anti-viral innate immunity and immune homeostasis显示文摘Immunity against pathogenic challenge requires the engagement of pathogen origin molecular signatures by innate immune sensors that are expressed on various immune and non-immune cells.This microbial pathogen primarily includes various bacteria or viruses.The sensing of viruses leads to the complex interaction of innate immune sensors,which consist of families of evolutionarily conserved germline-encoded molecules known as pathogen recognition receptors(PRRs).This family includes RIG-I-like receptors(RLRs),Toll-like receptors(TLRs),NOD-like receptors(NLRs)1 and DNA sensors(cGAS,IFI16,DAI and AIM2).2 The cytoplasmic helicases RIG-I and MDA5 are the key innate sensors that detect viral genomic RNAs.A few Toll-like receptors(TLRs),such as TLR3,TLR7,TLR8 and TLR9,are present on endocytic vesicles and are crucial for sensing nucleic acid from viruses and inducing the appropriate innate immune responses. | Shalabh Mishra Himanshu Kumar | 2018 | Cellular & Molecular Immunology2018，15，4： | 2 |
| 12 | Experimental Investigation of Centrifugal Pump Working as Turbine for Small Hydropower Systems显示文摘 | Himanshu Nautiyal Varun Varun Anoop Kumar Sanjay Yadav Sanjay Yadav | 2011 | Energy Science and Technology2011，，1： | 2 |
| 13 | Controlled release of FK506 from micropatterned PLGA films:potential for application in peripheral nerve repair显示文摘After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in patients.Current clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional functionality.FK506(Tacrolimus),an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered systemically.The objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via microgrooves.Photolithography was used to create micropatterned poly(lactide-co-glycolic acid)(PLGA) films embedded with FK506.Non-patterned,10/10 μm(ridge/groove width),and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and characterized.In vitro FK506 rate of release testing indicated that the films are capable of an extended(at least 56 days),controlled,and scalable release of FK506.Neurite extension bioactivity assay indicated that FK506 released from the films(concentration of samples tested ranged between 8.46–19.7 ng/m L) maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages(10 ng/m L FK506).The multi-functional FK506 embedded,micropatterned poly(lactide-co-glycolic acid) films developed in this study have potential to be used in the construction of peripheral nerve repair devices. | Brett Davis Susan Wojtalewicz Pratima Labroo Jill Shea Himanshu Sant Bruce Gale Jayant Agarwal | 2018 | Neural Regeneration Research2018，13，7： | 2 |
| 14 | Open arch reconstruction in the endovascular era: Analysis of 721 patients over 17 years显示文摘 | Himanshu J. Patel Christopher Nguyen Amy C. Diener Mary C. Passow Diane Salata G. Michael Deeb | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，6： | 2 |
| 15 | Acute psychosis:a presentation of cyanocobalamin deficiency megaloblastic ane-mia显示文摘 | Tripathi AK Verma SP Himanshu D | | 0，，3： | 1 |
| 16 | State Estimation and Tracking Problems:A Comparison Between Kalman Filter and Recurrent Neural Networks 显示文摘 | Kumar Chenna S Yogesh Kr Jain Himanshu Kapoor | 2004 | Springer-Verlag Berlin Heidelberg2004，，4： | 1 |
| 17 | Structural,dielectric relaxation and piezoelectric characterization of Sr2 substituted modified PMS-PZT ceramic 显示文摘 | BRAJESH K HIMANSHU A K SHARMA H | 2012 | Phys B: Condens Matter2012，407，： | 1 |
| 18 | Study and comparison of various image edge detection techniques 显示文摘 | Raman Maini Himanshu Aggarwal | 2009 | International Journal of Image Processing2009，3，1： | 1 |
| 19 | Modeling of semibatch esterification process for poly(ethylene terephthalate) synthesis显示文摘 | Himanshu P Gunter F Reinhard S | 2007 | Macromolecular Reaction Engineering2007，1，4： | 1 |
| 20 | Estimation of antiradical properties of antioxidants using DPPH <ce:glyph name='rad'/> assay: A critical review and results显示文摘 | Krishnanand Mishra Himanshu Ojha Nabo Kumar Chaudhury | 2011 | Food Chemistry2011，，4： | 1 |
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