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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Regulation of growth hormone receptor/binding protein, insulin- like growth factor ternary complex system in human cirrhosis显示文摘 | Donaghy A J Delhanty P J Ho K K | 2002 | J Hepatol2002，36，6： | 1 |
| 3 | Modelling of springback in creepforming thick aluminum sheets 显示文摘 | Ho K C Lin J Dean T A | 2004 | International Journal ofPlasticity2004，20，： | 1 |
| 4 | Electrochemical sensor for multiplex screening of genetically modified DNA:Identification of biotech crops by logic-based biomolecular analysis显示文摘 | Liao W C Chuang M C Ho J A A | 2013 | Biosensors and Bioelectronics2013，50，15： | 1 |
| 5 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 6 | Large area few-layer graphene films on arbitrary substrates by chemical vapor deposition显示文摘 | REINA A JIA X HO J | 2009 | Nano Letters2009，9，1： | 1 |
| 7 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 8 | Understanding the psychological motives behind microblogging显示文摘 | Qiu L Leung A K Ho J H | | 0，，： | 1 |
| 9 | Three-dimensional crystalline SiC nanowire flowers显示文摘 | Ho G W Wong A S W Kang D J | 2004 | Nanotechnology2004，15，8： | 1 |
| 10 | Large area, few-layer graphene films on arbitrary substrates by chemical vapor deposition 显示文摘 | Reina A Jia X Ho J | 2009 | Nano Lett2009，9，： | 1 |
| 11 | Early results with titani- um ossicular implants显示文摘 | Ho S Y Battista R A Wiet R J | 2003 | Otol Neurotol2003，24，2： | 1 |
| 12 | Nested decomposition far dynamic model显示文摘 | Ho J K Manne A S | 1974 | Mathematical Programming1974，6，： | 1 |
| 13 | The effects of physical activity, education, and body mass index on the aging brain显示文摘 | HO A J RAJI C A BECKERJT | 2011 | Hum Brain Mapp2011，32，9： | 1 |
| 14 | Nanothoranostics-a review of rccent publications显示文摘 | Wang L S Chuang M C Ho J A | 2012 | Int J Nanomcdicine2012，7，： | 1 |
| 15 | Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during winter period 显示文摘 | CAO J J LEE S C HO K F et a l | 2003 | Atmos Environ2003，，37： | 1 |
| 16 | Study of the sorption of divalent metal ion on to peat显示文摘 | Ho Y S Mckay G Wase D A J | 2000 | Adsorption Science & Tech- nology2000，18，7： | 1 |
| 17 | Short-term outcomes of 25-gauge vitreetomy with silicone oil for repair of complicated retinal detachment 显示文摘 | Shah C Ho A Regillo C Fineman M Vander J Brown G | 2008 | Retina2008，28，5： | 1 |
| 18 | Using Liposomal Fluorescent biolabels to develop an immunoaffinity ehromatographic biosensing system for biotin显示文摘 | HO J A A HUNG C H | 2008 | Anal Chem2008，80，16： | 1 |
| 19 | Phylogenetic composition of bacterioplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments 显示文摘 | Murray A E Ho llibaugh J T Orrego C | 1996 | Appl Environ Microbiol1996，62，7： | 1 |
| 20 | Case report:parachordoma of soft tissues of the arm显示文摘 | Clabeaux J Ho Jnowski L Valente A | 2008 | Clin Orthop Relat Res2008，466，5： | 1 |
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