|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | 25-Hydroxyvitamin D and risk of myocardial infarction in men:a prospective study显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch Intern Med2008，168，11： | 1 |
| 3 | A study on microstrue- ture in the brazing interface of WC-TiC-Co hard alloys显示文摘 | Li Y J Zou Z D Holly X Feng T Wang X H | 2002 | Int J Refract Met Hard Mater2002，20，： | 1 |
| 4 | Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo 显示文摘 | Drincic A Byun Y | 1999 | J Mol Cell Cardiol1999，31，9： | 1 |
| 5 | Clinical Lymphoma显示文摘 | MATTHEW Y HOLLY G RUBEN M | 2015 | Myeloma and Leukemia2015，15，1： | 1 |
| 6 | 25-Hydroxyvi- tamin D and risk of myocardial infarction in men: a prospective study显示文摘 | GIOVANNUCCI E LIU Y HOLLIS BW | 2008 | Archives of Internal Medicine2008，168，11： | 1 |
| 7 | 25-hydroxyvitaminD and risk of myocardial infarction in men显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch InternMed2008，168，11： | 1 |
| 8 | 25-hydroxyvitamin D and risk of myocardial infarction in men:a prospective study显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch Intern Med2008，168，11： | 1 |
| 9 | X ray diffraction and TEM analysis of Fe-Al alloy layer in coating of new hot dip aluminized steel 显示文摘 | LI Y J WANG J HOLLY X | 2003 | Materials Science and Technology2003，19，5： | 1 |
| 10 | X-ray diffraction and TEM analysis of Fe- AI alloy layer in coating of new hot dip aluminised steel显示文摘 | Li Y J Wang J Holly X | 2003 | Mater Sci Technol2003，19，5： | 1 |
| 11 | lmunobiological pecularitis of cholesteatoma in children: Quanlifications of epithelial proliferation by MIBI 显示文摘 | BUJIA MD HOLLY Y TAP1A MG | 1996 | Laryngoscope1996，106，： | 1 |
| 12 | 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study 显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | ArchlntemMed2008，168，11： | 1 |
| 13 | 25-hydroxyvita- min D and risk of myocardial infarction in men: a prospective study显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch Intern Med2008，，： | 1 |
| 14 | : 25 - hydroxyvitamin D and risk of myocardial infarction in men: a prospective study 显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch Intern Med2008，168，12： | 1 |
| 15 | 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study显示文摘 | Giovannucci E Liu Y Hollis BW | 2008 | Arch Intern Med2008，168，11： | 1 |
| 16 | Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo显示文摘 | Holly TA Drincic A Byun Y | | 0，，09： | 1 |
| 17 | Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 显示文摘 | Fridman J S Scherle P A Collins R Bum T C Li Y Li J Covington M B Thomas B Collier P Favata M F Wen X Shi J McGee R Haley P J Shepard S Rodgers J D Yeleswaram S Hollis G Newton R C Metcalf B Friedman S M Vaddi K | 2010 | J Immunol2010，184，9： | 1 |
| 18 | Acute delirium:differentiation and care显示文摘 | Holly C Cantwell ER Jadotte Y | | 0，，： | 1 |
| 19 | Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo显示文摘 | Holly TA Drincic A Byun Y | 1999 | J Mol Cell Cardiol1999，31，9： | 1 |
| 20 | X-ray diffraction and TEM analysis of Fe-Al alloy layer in coating of new hot dip aluminised steel显示文摘 | Li Y J Wang J Holly X | 2003 | Mater Sci Techn2003，19，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员