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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Dot immunogold filtration assay for rapid detection of anti-HAV IgM in Chinese显示文摘INTRODUCTION The hepatitis A virus specific immunoglobulin M(IgM)antibody is a specific serological marker forearly diagnosis of hepatitis A..At present,themethods used at home or abroad for detecting anti-HAV IgM are RIA,ELISA and SPHAI.The dotimmunogold combination assay that has beendeveloped since 1989 is a new technique with theproperty of simple and rapid immunologicaldetection,by using the red colloidal gold particles tolabel the antibodies as indicator,and the | Han FC Hou Y Yan XJ Xiao LY Guo YH | 2000 | World Journal of Gastroenterology2000，6，3： | 5 |
| 3 | Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis,acting possibly through antiinflammatory effect显示文摘 | Hou SW Liu CY Li YH | 2012 | CNS Neurosci Ther2012，18，： | 1 |
| 4 | Increased mdm2 expression in rat brain after transient middle cerebral artery occlusion显示文摘 | Tu YH Hou ST Huang ZG | 1998 | J of Cerebral Blood Flow and Metab1998，18，6： | 1 |
| 5 | Isotopes (6D and 6180) in precipitation, groundwater and surface water in the Ordos Plateau, China: Implications with respect to groundwater recharge and circulation显示文摘 | Yin Lid Hou GC Su XS Wang D Dong JQ Hao YH Wang XY | 2011 | Hydrogeology Journal2011，19，2： | 1 |
| 6 | Change and correlated factors of fast- ing level of the plasma endotoxin in subjects with different glucose toler- ances and body mass indices 显示文摘 | Liu YH Zhao TY Hou LQ | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban2013，44，5： | 1 |
| 7 | Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through immunomodulation effect 显示文摘 | Hou SW Liu CY Li YH | 2012 | CNS Neurosci Ther2012，18，11： | 1 |
| 8 | Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer 显示文摘 | Hou Q Wu YH Grabsch H | 2008 | Cancer Res2008，68，： | 1 |
| 9 | Factors influencing computer literacy of Taiwan and South Korea Nurses显示文摘 | Hus HM Hou YH Chang IC | 2009 | J Med Syst2009，33，2： | 1 |
| 10 | Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males 显示文摘 | Lee WC Lin YH Hou CP | 2013 | Clin Interv Aging2013，8，4： | 1 |
| 11 | Rolipram attenuates bleomycin AS-induced pulmonary fibrosis in rats 显示文摘 | PAN JB HOU YH ZHANG GJ | 2009 | Respirology2009，14，7： | 1 |
| 12 | A modified technique for neourethral anastomosis in orthotopic neobladder reconstruction 显示文摘 | Hou GL Li YH Zhang ZL | 2009 | Urology2009，74，5： | 1 |
| 13 | Genome rearrangements of completely sequenced strains of Yersinia pestis 显示文摘 | Liang Y Hou XX Wang YH | 2010 | J Clin Microbiol2010，48，5： | 1 |
| 14 | Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats 显示文摘 | Pan JB Hou YH Zhang GJ | 2009 | Respirology2009，14，7： | 1 |
| 15 | Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4显示文摘 | Hou YH Srour EF Ramsey H | 2005 | Blood2005，105，： | 1 |
| 16 | Treatment of intra-articular fractures with shape memory compression staples显示文摘 | Dai KR Hou XK Sun YH | | 0，，10： | 1 |
| 17 | PPARalpha agonist fenofi- brate protects the kidney from hypertensive injury in sponta- neously hypertensive rats via inhibition of oxidative stress and MAPK activity 显示文摘 | Hou X Shen YH Li C | 2010 | Biochem Biophys Res Commun2010，394，： | 1 |
| 18 | S100A6 gene have a positive influence on the growth and proliferation of gastric cancer cell MKN45 显示文摘 | Zhang L Hou YH Li N | 2009 | Chin Ger J Clin Onco12009，8，1： | 1 |
| 19 | Factors Influencing Computer Literacy of Taiwan and South Korea Nurses 显示文摘 | Hsu HM Hou YH Chang IC | 2009 | Journal of Medical Systems2009，33，2： | 1 |
| 20 | Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARalpha-dependent pathway 显示文摘 | Hsu YH Chen CH Hou CC | 2008 | Kidney Int2008，73，5： | 1 |
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