| 2 | Chemical Modifications on Linen forUnsaturated Polyester Composites显示文摘Linen was chemically modified by oleoyl chloride(OC) and stearoyl chloride(SC) to graft fatty moietiesonto fiber via ester connections. Pyridine was used as solvent. The reaction was simplified by reacting the compoundsin air at 60℃ for 6 h. Fourier transform infrared spectroscopy(FTIR) and thermal gravimetric analysis were con-ducted to characterize the treated fiber. The FTIR result confirms that the fatty portions have been successfullygrafted onto the fiber after the chemical modification. The thermal stability of the SC-modified linen(SCL) was simi-lar to that of the flax modified by oleoyl chloride(OCL). SCL and OCL demonstrated a temperature of 5% mass loss,which was above 200 ℃ and could meet the requirements of the processing conditions for most composites. The-reafter, the SCL-reinforced unsaturated polyester(UPE) composites were prepared and characterized. The compositepresented a much better impact strength of 61.1 J/m and tensile modulus of 1.69 GPa than those of UPE with appli-cable thermal stability. SCL has been shown to be a promising choice as reinforcing material for composites. | HU Qiuxue YAN Xinxin DONG Chenjun HU Wei | 2016 | Chemical Research in Chinese Universities2016，32，6： | 1 |
| 3 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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