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| 1 | 快速康复外科理念在前列腺癌根治术围手术期中应用的meta分析显示文摘目的:评价快速康复外科(ERAS)方案相比传统围手术期方案应用于前列腺癌根治术(RP)围手术期的有效性及安全性。方法:计算机检索PubMed、TheCochraneLibrary、EMBASE、中国知网、万方、维普数据库,查找快速康复外科(enhancedrecoveryaftersurgery,ERAS)应用于前列腺癌根治术围手术期的随机对照试验(randomizedcontrolled trial,RCT),检索时限为建库至2018年10月30日;依照文献纳入及排除标准,由2名研究者独立进行文献筛选、质量评价、提取资料,采用Revman 5.3软件进行meta分析。结果:共纳入6篇文献,含665例患者,ERAS组308例,对照组357例。Meta分析显示:与对照组比较,ERAS组术后住院时间明显缩短(WMD=-1.59,95%CI:-2.70~-0.49)、术后整体并发症发生率显著降低(RR=0.55,95%CI:0.38~0.80);按不同手术方式进行亚组分析,开放组(RRP)、腹腔镜组(LP)行ERAS术后住院时间明显缩短(WMD=-1.00,95%CI:-1.37~-0.63),(WMD=-2.80,95%CI:-3.35~-2.24),而机器人组(RALP)无统计学差异(WMD=0.24,95%CI:-2.21~2.69)。腹腔镜组行ERAS术后并发症总发生率显著缩短(RR=0.40,95%CI:0.27~0.61),而开放组及机器人组无统计学差异(RR=1.16,95%CI:0.23~5.87),(RR=0.99,95%CI:0.52~1.90)。腹腔镜组行ERAS术后出血发生率显著降低(RR=0.24,95%CI:0.08~0.66),而机器人组无统计学差异(RR=0.33,95%CI:0.02~6.71)。腹腔镜组及机器人组行ERAS术后首次排便时间均显著降低(WMD=-0.33,95%CI:-0.63~-0.02)、(WMD=-0.40,95%CI:-0.62~-0.18),开放组未报道术后出血率及首次排便时间。结论:ERAS应用于前列腺癌根治术中安全有效,尤其在腹腔镜下前列腺癌根治术中,其能明显缩短术后住院时间并降低并发症发生。 | 刘念 刘川 胡自力 高亮 HU TingBo | 2019 | 科学咨询2019，0，10： | 8 |
| 2 | Stereo matching using weigh- ted dynamic programming on a single-direction fore' connected tree 显示文摘 | HU Tingbo Qt Baojun WU Tao | 2012 | Computer Vision and Image Understanding2012，116，8： | 1 |
| 3 | Translation:Management of Coronavirus Disease 2019(COVID-19):Experience in Zhejiang Province,China显示文摘The current epidemic situation of coronavirus disease 2019(COVID-19)still remains severe.As the National Clinical Research Center for Infectious Diseases,The First Affiliated Hospital of the Zhejiang University School of Medicine is the primary medical care center for COVID-19 in Zhejiang Province.Based on the present expert consensus carried out by the National Health Commission and National Administration of Traditional Chinese Medicine,our team summarized and established an effective treatment strategy centered on“Four-Anti and Two-Balance”for clinical practice.The“Four-Anti and Two-Balance”strategy includes antivirus,anti-shock,antihypoxemia,and anti-secondary infection,and maintaining of water,electrolyte and acid/base balance and microecological balance.Simultaneously,an integrated multidisciplinary personalized treatment is recommended to improve therapeutic effects.The importance of early viral detection,dynamic monitoring of inflammatory indexes,and chest radiographs has been emphasized in clinical decision-making.Sputum was observed with the highest positive rate by reverse transcription-polymerase chain reaction(RTPRC).Viral nucleic acids could be detected in 10%of the patients’blood samples at the acute phase and 50%of patients had positive RT-PCR results in their feces.We also isolated live viral strains from feces,indicating potential infectiousness of feces.Dynamic cytokine detection was necessary to timely identify cytokine storms and for the application of the artificial liver blood purification system.The“Four-Anti and Two-Balance”strategy effectively increased cure rates and reduced mortality.Early antiviral treatment alleviated disease severity and prevented illness progression.We found that lopinavir/ritonavir combined with abidol showed antiviral effects against COVID-19.Shock and hypoxemia were usually caused by cytokine storms.The artificial liver blood purification system was able to rapidly remove inflammatory mediators and block the cytokine storm.Moreover,it also contributed to the balance of fluids,electrolytes,and acids/bases and thus improved treatment efficacy during critical illness.For cases of severe illness,early and also short periods of moderate glucocorticoid administration was supported.Patients with an oxygenation index below 200mmHg were transferred to the intensive care unit.Conservative oxygen therapy was preferred and noninvasive ventilation(NIV)was not recommended.Patients with mechanical ventilation were strictly supervised with cluster ventilator-associated pneumonia prevention strategies.Antimicrobial prophylaxis was prescribed rationally and was not recommended,except for patients with a long course of disease,repeated fever,and elevated procalcitonin,similarly secondary fungal infections were of concern.Some patients with COVID-19 showed intestinal microbial dysbiosis with decreased genus such as Lactobacillus and Bifidobacterium.Nutritional and gastrointestinal function should;therefore,be assessed for all patients.Nutritional support and application of prebiotics or probiotics were suggested to regulate the balance of intestinal microbiota and reduce the risk of secondary infections due to bacterial translocation.Anxiety and fear were common in patients with COVID-19.Therefore,we established a dynamic assessment and warning for psychological crises.We also integrated Chinese medicine in the treatment to promote rehabilitation.We optimized nursing processes for severe patients to promote their rehabilitation.Since viral clearance patterns after severe acute respiratory syndrome coronavirus 2 infections remained unclear,2 weeks quarantine for discharged patients was required,and a regular following-up was also needed.These Zhejiang experiences and suggestions have been implemented in our center and achieved good results.However,since COVID-19 was a newly emerging disease,more work is warranted to further improve strategies of prevention,diagnosis,and treatment for COVID-19. | Kaijin Xu Hongliu Cai Yihong Shen Qin Ni Yu Chen Shaohua Hu Jianping Li Huafen Wang Liang Yu He Huang Yunqing Qiu Guoqing Wei Qiang Fang Jianying Zhou Jifang Sheng Tingbo Liang Lanjuan Li | 2020 | Infectious Microbes & Diseases2020，2，2： | 0 |
| 4 | Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation显示文摘Phosphatidylcholines(PCs)are major phospholipids in the mammalian cell membrane.Structural remodeling of PCs is associated with many biological processes.Lysophosphatidylcholine acyltransferase 3(Lpcat3),which catalyzes the incorporation of polyunsaturated fatty acyl chains into the sn-2 site of PCs,plays an important role in maintaining plasma membrane fluidity.Adipose tissue is one of the main distribution organs of Lpcat3,while the relationship between Lpcat3 and adipose tissue dysfunction during overexpansion remains unknown.In this study,we reveal that both polyunsaturated PC content and Lpcat3 expression are increased in abdominal adipose tissues of high-fat diet-fed mice when compared with chow-diet-fed mice,indicating that Lpcat3 is involved in adipose tissue overexpansion and dysfunction.Our experiments in 3T3-L1 adipocytes show that inhibition of Lpcat3 does not change triglyceride accumulation but increases palmitic acid-induced inflammation and lipolysis.Conversely,Lpcat3 overexpression exhibits anti-inflammatory and anti-lipolytic effects.Furthermore,mechanistic studies demonstrate that Lpcat3 deficiency promotes reactive oxygen species(ROS)generation by increasing NOX enzyme activity by facilitating the translocation of NOX4 to lipid rafts,thereby aggregating 3T3-L1 adipocyte inflammation induced by palmitic acid.Moreover,overexpression of Lpcat3 exhibits the opposite effects.These findings suggest that Lpcat3 protects adipocytes from inflammation during adipose tissue overexpansion by reducing ROS generation.In conclusion,our study demonstrates that Lpcat3 deficiency promotes palmitic acid-induced inflammation in 3T3-L1 adipocytes by enhancing ROS generation. | Jiachun Hu Yan Deng Tingbo Ding Jibin Dong Yuning Liang Bin Lou | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
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