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| 1 | Characteristics ofa glutamine cartier in skeletal muscle have important consequences for nitrogen loss in injury, infection and chronic disease 显示文摘 | Rennie M J Hundal HS Brbji P etal | 1986 | Lancet1986，56，2： | 1 |
| 2 | Regulation of glu-cose transport and GLUT1glucose transporter expressionby O2in muscle cells in culture显示文摘 | Bashan N Burdett E Hundal HS | 1992 | Am J Physiol1992，262，31： | 1 |
| 3 | Protein kinase B (PKB/Akt) - a key regulator of glucose transport显示文摘 | Haiduch E Litherlandl GJ Hundal HS | 2001 | FEBS Lett2001，492，3： | 1 |
| 4 | Glucose transport correlates with GLUT2 abundance in rat liver during altered thyroid status显示文摘 | Kemp HF Hundal HS Taylor PM | 1997 | Mol Cell Endocrinol1997，128，12： | 1 |
| 5 | Glucose transport correlates with Glut2 abundance in rat liver during altered thyroid status显示文摘 | KEMP HF HUNDAL HS TAYLOR PM | 2005 | Mol Cell Endocrinol2005，128，： | 1 |
| 6 | Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes显示文摘 | Cummings E Hundal HS Wackerhage H | 2004 | Mol Cell Biochem2004，261，12： | 1 |
| 7 | Mechanism by which metformin reduces glucose production in type 2 diabetes显示文摘 | Hundal HS Ramlal T Reyes R | 2000 | Diabetes2000，49，： | 1 |
| 8 | Protein kinase B(PKB/ Akt)-a key regulator of glucose transport 显示文摘 | Hajduch E Litherland GJ Hundal HS | 2001 | FEBS Lett2001，492，3： | 1 |
| 9 | Regulation of glucose transport and GLUT1 glucose transport expression by O2 in muscles in cuhure 显示文摘 | Bashan N Burdett E Hundal HS | 1992 | Physiology1992，262，： | 1 |
| 10 | Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells显示文摘 | Zhao H Hyde R Hundal HS | 2004 | J Physiol2004，560，1： | 1 |
| 11 | Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells显示文摘 | Hundal HS Ramlal T Reyes R | 1992 | Endocrinology1992，131，3： | 1 |
| 12 | Protein kinase B (PKB/ Akt)--a key regulator of glucose transport?显示文摘 | Lithedand GJ Hundal HS | 2001 | FEBS Lett2001，492，3： | 1 |
| 13 | Protein kinase B (PKB/Akt)--a key regulator of glucose transport显示文摘 | Hajduch E Litherland GJ Hundal HS | | 0，，03： | 1 |
| 14 | Characteristics of a glutamine carrier in skeletal muscle have important conseq uences for nitrogen loss in injury, infection and chronic disease 显示文摘 | Rennie MJ Hundal HS Babji P | 1986 | Lancet1986，2，： | 1 |
| 15 | Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient sig- naling显示文摘 | Hundal HS Taylor PM | 2009 | Am J Physiol Endocrinol Metab2009，296，4： | 1 |
| 16 | Skeletal muscle tissue coutains extracellular aminopeptidase activity against Als-Gln but no peptide transporter 显示文摘 | Hundal HS Rennie MJ | 1988 | Eur J Clin Invest1988，18，： | 1 |
| 17 | Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes显示文摘 | Hundal HS Wackerhage H | 2004 | Mol Cell Biochem2004，261，2： | 1 |
| 18 | Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells显示文摘 | Watson ML Coghlan M Hundal HS | 2009 | Bio- chem J2009，417，3： | 1 |
| 19 | Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes显示文摘 | Cummings E Hundal HS Wackerhage H | 2004 | Molecular and Cellular Biochemistry2004，261，12： | 1 |
| 20 | 去除神经支配大鼠骨骼肌中钠钾三磷酸腺苷酶表达的变化(英文)显示文摘背景:胰岛素诱导的离子运输改变可影响代谢调节,并且胰岛素抵抗条件下钠钾三磷酸腺苷酶活性的降低导致高血压以及糖原合成、葡萄糖氧化和ATP产生的减少。目的:观察钠钾三磷酸腺苷酶在胰岛素抵抗模型中的表达调控。设计:对照实验。单位:英国邓迪大学生命科学学院分子生理学系。材料:实验于1999-10/2000-02完成。使用15只体质量200~250g的清洁级成年雄性SpragueDawley大鼠。每次实验使用5只,相同实验重复3次。方法:去除大鼠一侧后肢神经支配,4d后将骨骼肌从去除神经支配的后肢和对侧对照后肢中解剖并分离,从红色肌肉(比目鱼与红色腓肠肌)和白色腓肠肌中分离粗制细胞膜。应用免疫印迹法和Northern杂交分析法分别检测蛋白质和mRNA的表达。使用Bio-RadGS-670图像密度仪对蛋白质和mRNA的信号强度进行定量。主要观察指标:对照侧和去除神经支配后肢骨骼肌中钠钾三磷酸腺苷各亚基蛋白质和mRNA表达水平的比较。结果:15只大鼠全部进入结果分析。与对照侧相比,去除神经支配的后肢中:①红色骨骼肌中α2和β1亚基的蛋白质表达分别下降46%和77%。在红色和白色骨骼肌中,α1亚基的蛋白质表达分别增加了20%和15%。β2亚基的蛋白质表达在红色和白色骨骼肌中均未发生显著变化。②在红色腓肠肌和比目鱼肌中,α2亚基的mRNA水平分别下降了29%和39%,β1亚基的mRNA水平分别下降了80%和52%。在红色和白色腓肠肌中,α1亚基的mRNA水平分别增加了9倍和1.3倍。β2亚基的mRNA水平在红色腓肠肌中无显著变化,但在白色腓肠肌中减少了59%。结论:①在去除神经支配的大鼠骨骼肌中,钠钾三磷酸腺苷酶各亚基的表达受转录和转录后双重调控。②α2和β1亚基的蛋白质表达显著下降的结果提示,在大鼠骨骼肌中,去除神经支配造成的胰岛素抵抗使原本受胰岛素调节的钠钾三磷酸腺苷酶亚基的表达机制被破坏。 | 赵海燕 Hundal HS | 2006 | 中国临床康复2006，10，32： | 1 |
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