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| 1 | Long-term monitoring of PCDD/PCDF and other unintentionally produced POPs-Concepts and case studies from Europe显示文摘During the start-up and unstable combustion periods,even the state-of-the-art incinerators emit polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/PCDF) in stack gases at concentrations that are up to 1000 times higher than normal operation. Therefore,incinerators and other sources with variation of PCDD/PCDF release into air cannot be reliably monitored by the conventional short-term sampling that covers only 0.1%to 0.2%of the yearly operating time.A more comprehensive monitoring regime is required.This paper describes different applications of continuous PCDD/PCDF sampling in some European countries.The cases demonstrate that flexible regimes for continuous sampling can be crafted and applied by governments or regional/local authorities.Such regimes range from a countrywide,continuous requirement for selected facility types(e.g.,waste incinerators) to a facility-specific regime that applies,for example,to new facilities for a defined time period until the facility has demonstrated continuous compliance with regulatory limits. Countries implementing the Stockholm Convention are suggested to evaluate in their Best available technology/Best environmental practice(BAT/BEP) activities the usefulness of long-term sampling by,for example,designating institutes related to the environmental ministry or regional authorities to supervise long-term sampling regimes at relevant facilities in their country/areas,beginning with priority sources(e.g.,facilities used for destruction of persistent organic pollutants(POPs) or hazardous waste processing) . This paper presents and discusses the results of the AMESA long-term monitoring system having demonstrated that in addition to PCDD/PCDF all other unintentionally produced POPs listed in the Stockholm Convention could be supervised. | REINMANN Jürgen WEBER Roland HAAG Roland | 2010 | Science China Chemistry2010，53，5： | 8 |
| 2 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 3 | IL-1 and BMPs interactive players of cartilage matrix degradation and regeneration 显示文摘 | AIGNER T SOEDER S HAAG J | 2006 | Eur Cell Mater2006，12，： | 1 |
| 4 | Assessing the relative efficiency of agricultural production units in the Blackland Prairie, Texas 显示文摘 | Haag S Jaska P Semple J | 1992 | Applied Economics1992，24，5： | 1 |
| 5 | Design of an electric propulsion system for a quadrotor unmanned aerial vehicle显示文摘 | STEPANIAK M J van GRAAS F HAAG M U | 2009 | Journal of Aircraft2009，46，3： | 1 |
| 6 | Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line Hep G2,the rat hepatoma cell line H4IIE,and rat primary hepatocytes:Comparison of relative potencies显示文摘 | Zeiger M Haag R Hckel J | 2001 | Toxicological Sciences2001，63，1： | 1 |
| 7 | Pereutaneous venous thrombectomy using the Arrow-Trerotola pereutaneous thrombolytie device (PTD) with temporary caval filtration:in vitro investigations显示文摘 | Wildberger JE Haage P Bovelander J | 2005 | Cardiovase Intervent Radiol2005，28，2： | 1 |
| 8 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 9 | Highly efficient transduction and expression of cytokine genes in human tumor cells by means of autonomous parvovirus vectors: generation of antitumor responses in recipient mice 显示文摘 | Haag A Menten P Van Damme J el al | 2000 | Human Gene Therapy2000，11，4： | 1 |
| 10 | 显示文摘 | White J E Haag A P Pews R G | 1996 | Journal of Polymer Science Part A: Polymer Chemistry1996，34，14： | 1 |
| 11 | Repression of anti-prolif- erative factor Tobl in osteoarthritic cartilage 显示文摘 | Gebauer M Saas J Haag J | 2005 | Arthritis Res Ther2005，7，2： | 1 |
| 12 | Functional transcranial Doppler sonography and a spatial orientation paradigm identify the non-domi- nant hemisphere显示文摘 | Dorst J Haag A Knake S et ai | 2008 | Brain Cogn2008，68，： | 1 |
| 13 | Experimen- tal andnumerical investigation of the dynamics in spatial flu- id-filledpiping systems 显示文摘 | HERRMANN J HAAG T ENGELKE S | 2008 | Journal of the Acoustical So- ciety of America2008，123，5： | 1 |
| 14 | Mechanistic con- siderations in acid catalyzed cracking of olefins 显示文摘 | BUCHANAN J S SANTIESTEBAN J G HAAG W O | 1996 | Catal1996，158，1： | 1 |
| 15 | Assessing the Relative Efficiency of Agricultural Production Units in the Blackland Prairie, Texas 显示文摘 | Haag S Jaska P Semple J | 1992 | Applied Economics1992，24，5： | 1 |
| 16 | Mechanistic considerations in acid-catalyzed cracking of olefins 显示文摘 | Buchanan J S Santiesteban J G Haag W O | 1996 | Journal of Catalysis1996，158，： | 1 |
| 17 | Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells显示文摘 | Haag P Bektic J Bartsch G | 2005 | Journal of Steroid Biochemistry & Molecular2005，96，34： | 1 |
| 18 | Limonene-inducedregression of mammary carcinomas显示文摘 | HAAG J D LINDSTROM M J GOULD M N | 1992 | Cancer Research1992，52，14： | 1 |
| 19 | Mechanistic Considerations in Acid-Catalyzed Cracking of Olefins显示文摘 | Buchanan J S Santiesteban J G Haag W O | 1996 | J Catal1996，158，1： | 1 |
| 20 | Rate constants of reactions of ozone with organic and inorganic compounds in water-Ⅲ:Inorganic compounds and radicals显示文摘 | Hoigné J Bader H Haag W R | 1985 | Wat Res1985，19，8： | 1 |
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