|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete compilation of matrix metalloproteinase expression in human malignant gliomas显示文摘Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy. | Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus Giles H Vince | 2012 | World Journal of Clinical Oncology2012，3，5： | 18 |
| 2 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 3 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 4 | Cancer-Related Inflammation显示文摘 | Juliana Candido Thorsten Hagemann | 2013 | Journal of Clinical Immunology2013，，1： | 2 |
| 5 | Compa-rison between early and delayed systemic treatmen twith candesartan of rats after ischaemic stroke显示文摘 | Jan Brdon Sabine Kaiser Friederike Hagemann | 2007 | Hypertension2007，25，： | 1 |
| 6 | Macrophages induce inva- siveness of epithelial cancer cells via NF-kappa B and JNK 显示文摘 | Hagemann T Wilson J Kulbe H | 2005 | J lmmunol2005，175，： | 1 |
| 7 | Increased long-term potentiation in the surround of experimentally induced focal cortical in- farction显示文摘 | Hagemann G Redecker C | 1998 | Aunul Neural1998，44，2： | 1 |
| 8 | Tissue- and stage-specific modulation of RNA editing of the psbF and psbL transcript from spinach plastids-a new regulatory mechanism?显示文摘 | Bock R Hagemann R K?ssel H Kudla J | 1993 | Mol Gen Genet1993，240，2： | 1 |
| 9 | Enhanced invasive- ness of breast cancer cell lines upon co-cultivation with macro- phages is due to TNF-alpha dependent up-regulation of matrix metalloproteases 显示文摘 | Hagemann T Robinson SC Schulz M | 2004 | Carcinogenesis2004，，： | 1 |
| 10 | Influence of red jersey color on physical parameters in combat sports显示文摘 | DREISKAEMPER D STRAUSS B HAGEMANN N BfiSCH D | 2013 | Journal of sport & exercise psychology2013，35，： | 1 |
| 11 | High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments显示文摘 | Hagemann C Meyer C Stojic J | 2006 | J Neurosci Methods2006，156，12： | 1 |
| 12 | Up for Mischid? IL 17/Th17 in the tumour microenvironment显示文摘 | MANIATI E SOPER R HAGEMANN T | 2010 | Oncogene2010，29，： | 1 |
| 13 | Germ-line transmission of aplanned a heration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells 显示文摘 | Koller BH Hagemann LJ DoetschmanT | 1989 | Proc Natl Acad Sci USA1989，86，22： | 1 |
| 14 | Distribution of glutamate receptor subunits in experimentally induced cortical malformations显示文摘 | HAGEMANN G KLUSKA M M REDECKER C | 2003 | Neuroscience2003，117，4： | 1 |
| 15 | Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain显示文摘 | Buchkremer-Ratzmann I August M Hagemann G | 1996 | Stroke1996，27，： | 1 |
| 16 | Inflammation and canc- er: a double-edged sword 显示文摘 | Hagemann T Balkwill F Lawrence T | 2007 | Cancer Cell2007，12，4： | 1 |
| 17 | Cancer- related inflammation 显示文摘 | Candido J Hagemann T | 2013 | J C/in Immunol2013，33，1： | 1 |
| 18 | When the referee sees red--' 显示文摘 | HAGEMANN N STRAUSS B LEISSING J | 2008 | Psychological Science2008，19，： | 1 |
| 19 | Recurrent posterior reversible encephalopathy syndrome (PRES)显示文摘 | Hagemann G Ugur T Witte OW | 2004 | J Hum Hypertens2004，18，4： | 1 |
| 20 | Synthesis of the compatible solutes glucosylglycerol and trehalose by salt-stressed cells of Stenotrophomonas strains显示文摘 | Anja Roder Eik Hoffmann Martin Hagemann Gabriele Berg | 2004 | FEMS Microbiology Letters2004，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员