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| 1 | In situ scattering study of multiscale structural evolution during liquid–liquid phase transition in Mg-based metallic glasses显示文摘The glass-forming ability of Mg-Cu-Gd alloys could be significantly promoted with the addition of Ag.A calorimetric anomaly could be observed in the supercooled liquid region of the Mg-Cu-Ag-Gd metallic glass,indicating the occurrence of a liquid-state phase transition driven by entropy.However,the underlying mechanism of the polyamorphous phase transition remains unsettled.In the paper,in situ scattering techniques were employed to reveal multiscale structure evidence in a Mg65Cu15Ag10Gd10metallic glass with an anomalous exothermic peak upon heating.Resistivity measurements indicate a reentrant behavior for the Mg-Cu-Ag-Gd metallic glass in the anomalous exothermic peak temperature region during heating.In situ synchrotron diffraction results revealed that the local atomic structure tends to be ordered and loosely packed first,followed by reentering into the initial state upon heating.Moreover,time-resolved small-angle synchrotron X-ray scattering(SAXS) results show an increase in nanoscale heterogeneity first followed by a reentrant supercooled liquid behavior.A core-shell structure model has been used to fit the SAXS profiles when polyamorphous phase transition occurs.In contrast,there is no structure anomaly for the reference Mg-Cu-Gd alloy system.The detailed multiscale structural evidence suggests the occurrence of a liquid-liquid phase transition followed by a reentrant behavior in the MgCu-Ag-Gd metallic glass.Our results deepen the understanding of the structural origin of the glass-forming ability and shed light on the possibility of tuning the physical and mechanical properties by heat-treatment in the supercooled liquid region of Mg-based metallic glasses. | Kang-Hua Li Jia-Cheng Ge Si-Nan Liu Shu Fu Zi-Xuan Yin Wen-Tao Zhang Guo-Xing Chen Shao-Chong Wei Hua Ji Tao Feng Qi Liu Xun-Li Wang Xiao-Bing Zuo Yang Ren Horst Hahn Si Lan | 2021 | Rare Metals2021，40，11： | 3 |
| 2 | Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization 显示文摘 | Hahn WC Wei W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 3 | Dissociation among in vitro telomerase activity, telomerase maintenance, and cellular immortalization 显示文摘 | Counter CM Hahn WC Wei W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 4 | Firing PbO-free Glass Enamels Using the CW-CO2 -Laser显示文摘 | Hahn K Weiβmann R | 1995 | Glass Sci Technol1995，，： | 1 |
| 5 | Dissociation among in vitro telomerase activity,telomere maintenance,and cellular immortalization显示文摘 | Counter C M Hahn W C Wei W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 6 | An XML-enabled data extrac- tion tool kit for web 显示文摘 | Liu Ling Pu Calton Hahn Wei | 2001 | Information systems2001，26，8： | 1 |
| 7 | Antibody neutralization and escape by HIV-1 显示文摘 | Wei X Decker JM Wang S Hui H Kappes JC Wu X Salazar-Gonzalez JF Salazar MG Kilby JM Saag MS Komarova NL Nowak MA Hahn BH Kwong PD Shaw GM | 2003 | Nature2003，422，6929： | 1 |
| 8 | Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization 显示文摘 | COUNTER CM HAHN WC WEI W | 1998 | Proc Natl Acad Sci U S A1998，95，14： | 1 |
| 9 | A Healable, Semitransparent Silver Nanowire‐Polymer Composite Conductor显示文摘 | Chaokun Gong Jiajie Liang Wei Hu Xiaofan Niu Sungwon Ma H. Thomas Hahn Qibing Pei | 2013 | Adv Mater2013，，30： | 1 |
| 10 | Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization显示文摘 | Counter CM Hahn WC Wei W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 11 | Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization 显示文摘 | Counter CM Hahn WC Wei W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 12 | Dissociation among in vitro telomerase activity, telomerase maintenance, and cellular immortalization 显示文摘 | HAHN W C WEI W | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 13 | Erratum to:Excellent long-term reactivity of inhomogeneous nanoscale Fe-based metallic glass in wastewater purification(vol 63,issue 3,pg 453-466,2020)显示文摘In the version of the article originally published in the volume 63,ssue 3,2020 of Sci China Mater(2020,63(3):453-46,https:/doi.org/10.1007/s40843-019-1205-5),the affiliations of the authors were incorrectly labeled. | Shuang-Qin Chen Ke-Zhen Hui Liang-Zheng Dong Zhun Li Qing-hua Zhang Lin Gu Wei Zhao Si Lan Yubin Ke Yang Shao Horst Hahn Ke-Fu Yao | 2022 | Science China Materials2022，65，10： | 0 |
| 14 | finDr:A web server for in silico D-peptide ligand identification显示文摘In the rapidly expanding field of peptide therapeutics,the short in vivo half-life of peptides represents a considerable limitation for drug action.D-peptides,consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids(AAs),do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation,resulting in a favourable pharmacokinetic profile.To experimentally identify D-peptide binders to interesting therapeutic targets,so-called mirror-image phage display is typically performed,whereby the target is synthesized in D-form and L-peptide binders are screened as in conventional phage display.This technique is extremely powerful,but it requires the synthesis of the target in D-form,which is challenging for large proteins.Here we present finDr,a novel web server for the computational identification and optimization of D-peptide ligands to any protein structure(https://findr.biologie.uni-freiburg.de/).finDr performs molecular docking to virtually screen a library of helical 12-mer peptides extracted from the RCSB Protein Data Bank(PDB)for their ability to bind to the target.In a separate,heuristic approach to search the chemical space of 12-mer peptides,finDr executes a customizable evolutionary algorithm(EA)for the de novo identification or optimization of D-peptide ligands.As a proof of principle,we demonstrate the validity of our approach to predict optimal binders to the pharmacologically relevant target phenol soluble modulin alpha 3(PSMα3),a toxin of methicillin-resistant Staphylococcus aureus(MRSA).We validate the predictions using in vitro binding assays,supporting the success of this approach.Compared to conventional methods,finDr provides a low cost and easy-to-use alternative for the identification of D-peptide ligands against protein targets of choice without size limitation.We believe finDr will facilitate D-peptide discovery with implications in biotechnology and biomedicine. | Helena Engel Felix Guischard Fabian Krause Janina Nandy Paulina Kaas Nico Hofflin Maja Kohn Normann Kilb Karsten Voigt Steffen Wolf Tahira Aslan Fabian Baezner Salom´e Hahne Carolin Ruckes Joshua Weygant Alisa Zinina Emir Bora Akmeriç Enoch B.Antwi Dennis Dombrovskij Philipp Franke Klara L.Lesch Niklas Vesper Daniel Weis Nicole Gensch Barbara Di Ventura Mehmet Ali Oztürk | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 0 |
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