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| 1 | Clinical implications of hedgehog signaling pathway inhibitors显示文摘Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was established through studies of a rare familial disease, Gorlin syndrome, in 1996. Follow-up studies revealed activation of this pathway in basal cell carcinoma, medulloblastoma and, leukemia as well as in gastrointestinal, lung, ovarian, breast, and prostate cancer. Targeted inhibition of Hh signaling is now believed to be effective in the treatment and prevention of human cancer. The discovery and synthesis of specific inhibitors for this pathway are even more exciting. In this review, we summarize major advances in the understanding of Hh signaling pathway activation in human cancer, mouse models for studying Hh- mediated carcinogenesis, the roles of Hh signaling in tumor development and metastasis, antagonists for Hh signaling and their clinical implications. | Hailan Liu Dongsheng Gu Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，1： | 11 |
| 2 | Novel MSX1 variants identified in families with nonsyndromic oligodontia显示文摘The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants.Whole-exome sequencing(WES)and Sanger sequencing were performed to identify the causal gene variants in five families with nonsyndromic oligodontia,and a series of bioinformatics databases were used for variant confirmation and functional prediction.Phenotypic characterization of the members of these families was described,and an in vitro analysis was performed for functional evaluation.Five novel MSX1 heterozygous variants were identified:three missense variants[c.662A>C(p.Q221P),c.670C>T(p.R224C),and c.809C>T(p.S270L)],one nonsense variant[c.364G>T(p.G122*)],and one frameshift variant[c.277delG(p.A93Rfs*67)].Preliminary in vitro studies demonstrated that the subcellular localization of MSX1 was abnormal with the p.Q221P,p.R224C,p.G122*,and p.A93Rfs*67 variants compared to the wild type.Three variants(p.Q221P,p.G122*,and p.A93Rfs*67)were classified as pathogenic or likely pathogenic,while p.S270L and p.R224C were of uncertain significance in the current data.Moreover,we summarized and analysed the MSX1-related tooth agenesis positions and found that the type and variant locus were not related to the severity of tooth loss.Our results expand the variant spectrum of nonsyndromic oligodontia and provide valuable information for genetic counselling. | Jinglei Zheng Miao Yu Haochen Liu Tao Cai Hailan Feng Yang Liu Dong Han | 2021 | International Journal of Oral Science2021，13，1： | 4 |
| 3 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 4 | A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation显示文摘A 2.5-dimensional method in frequency wave-number domain is developed to investigate the mode waves in a deviated borehole penetrating a transversely isotropic formation. The phase velocity dispersion characteristics of the fast and slow flexural mode waves excited by a dipole source are computed accurately at various deviation angles for both hard and soft formations. The sensitivities of the flexural mode waves to all elastic constants in a transversely isotropic formation are calculated. Numerical results show that, for a soft formation, the fast flexural mode wave is dominated by c66 at high deviation angles and low frequencies, while the slow flexural mode wave is dominated by c44 at the same conditions. Waveforms in time domain are also presented to support the conclusions. | LIU Le LIN WeiJun ZHANG HaiLan WANG XiuMing | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 2 |
| 5 | Development of universal genetic markers based on single-copy ortholog (Cos Ⅱ) genes in Poaceae 显示文摘 | LIU Hailan GUO Xiaoqin WU Jiasheng | 2013 | Plant Cell Rep2013，32，3： | 1 |
| 6 | Construction of Photoresponsive 3D Structures Based on Triphenylethylene Photochromic Building Blocks显示文摘Photoresponsive materials have been widely used in sensing,bioimaging,molecular switches,information storage,and encryption nowadays.Although a large amount of photoresponsive materials have been reported,the construction of these smart materials into precisely prescribed complex 3D geometries is rarely studied.Here we designed a novel photoresponsive material methyl methacrylate containing triphenylethylene(TrPEF_(2)-MA)that can be directly used for digital light processing(DLP)3D printing.Based on TrPEF_(2)-MA,a series of photoresponsive 3D structures with reversible color switching under ultraviolet/visible light irradiations were fabricated.These complex photoresponsive 3D structures show high resolutions(50μm),excellent repeatability(25 cycles without fatigue),and tunable saturate color degrees.Multicomponent DLP 3D printing processes were also carried out to demonstrate their great properties in information hiding and information-carrying properties.This design strategy for constructing photoresponsive 3D structures is attractive in the area of adaptive camouflage,information hiding,information storage,and flexible electronics. | Xiayu Zhang Fukang Liu Beibei Du Rongjuan Huang Simin Zhang Yunfei He Hailan Wang Jingjing Cui Biao Zhang Tao Yu Wei Huang | 2022 | Research2022，，4： | 1 |
| 7 | Direct bandgap engineering with local biaxial strain in few-layer MoS2 bubbles显示文摘Nano Research volume 13,pages2072–2078(2020)Cite this article 211 Accesses Metrics details Abstract Strain engineering provides an important strategy to modulate the optical and electrical properties of semiconductors for improving devices performance with mechanical force or thermal expansion difference.Here,we present the investigation of the local strain distribution over few-layer MoS2 bubbles,by using scanning photoluminescence and Raman spectroscopies.We observe the obvious direct bandgap emissions with strain in the few-layer MoS2 bubble and the strain-induced continuous energy shifts of both resonant excitons and vibrational modes from the edge of the MoS2 bubble to the center(10μm scale),associated with the oscillations resulted from the optical interference-induced temperature distribution.To understand these results,we perform ab initio simulations to calculate the electronic and vibrational properties of few-layer MoS2 with biaxial tensile strain,based on density functional theory,finding good agreement with the experimental results.Our study suggests that local strain offers a convenient way to continuously tune the physical properties of a few-layer transition metal dichalcogenides(TMDs)semiconductor,and opens up new possibilities for band engineering within the 2D plane. | Yang Guo Bin Li Yuan Huang Shuo Du Chi Sun Hailan Luo Baoli Liu Xingjiang Zhou Jinlong Yang Junjie Li Changzhi Gu | 2020 | Nano Research2020，13，8： | 1 |
| 8 | Injectable tissue-engineered bone composed of human adipose-derived stromal cells and platelet-rich plasma显示文摘 | Liu Yunsong Zhou Yongsheng Feng Hailan | 2008 | Biomaterials2008，29，23： | 1 |
| 9 | Injectable tissue-engineered bone composed of human adipose-derived stromal cells and platelet-rich plasma显示文摘 | Liu Yunsong Zhou Yongsheng Feng Hailan | 2008 | Biomaterials2008，29，23： | 1 |
| 10 | Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia显示文摘Anorexia nervosa(AN)is a severe eating disorder that can eventually lead to death,buteffective the rapiesare missing dueto a lack of knowledge about its pathophysiology.Dopamine(DA)neurons in theventral tegmental area(VTA)and serotonin(5-HT)neurons in the dorsal Raphe nucleus(DRN)play essential roles in the control of eating and have been reported to be as sociated with human AN(Zhou and Palmiter,1995;Xu et al.,2017;Watson et al.,2019;He et al.,2021). | Hailan Liu Xing Cai Yanlin He Yong Xu | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 11 | The Budget System of Transnational Investment and its Measuring Model显示文摘 | Hanfang Bo Hailan Liu Xudong Zhou | 2004 | China-USA Business Review2004，3，4： | 0 |
| 12 | Effect of pressure on the feeding characteristics of ZCuZn16Si4 alloy显示文摘The experimental and numerical simulation methods were employed to study the effect of pressure on the feeding characteristics of ZCuZn16Si4 alloy castings. The results proved that different pressures would lead to different feeding distance of riser over a suitable pressure range, and the pressure can be used to greatly improve the feeding characteristics compared with gravity casting. It should be pointed out that current porosity criteria in the numerical simulation codes cannot yet be applied well enough to predict the porosity defects of low-pressure copper alloy castings. | Li Hailan Sun Xun Zhang Shiyan Liu Xiaofu Qi Xiaobing Wang Penghua Yu Bo | 2008 | China Foundry2008，5，2： | 0 |
| 13 | Study on Beautiful Countryside Construction in Xihu Lijia Village, Qianfang Town, Jinxian County显示文摘By reviewing the beautiful countryside construction in Xihu Lijia Village, Qianfang Town, Jinxian County, this paper further explored the concept of building happy and harmonious countryside, provided theoretical and technical instruction for the construction of 'ecological settlement', 'ecological environment', 'ecological economy', 'ecological culture', in order to instruct the construction of beautiful countryside. | SUN Hailan LIU Xiaodong HONG Liang | 2015 | Journal of Landscape Research2015，7，3： | 0 |
| 14 | Synthesis of Caffeic Acid Sulphonamide Derivatives and Preliminary Exploration of Their Biological Applications显示文摘Stnictural modification of native compounds is an effective way to develop new dmgs with increased pharmacological activities and improved material characteristics.In this study,cafteic acid sulphonamide derivatives(CSs)were synthesised by conjugating sulphonamides to the backbone of cafteic acid.The structures of these derivatives were elucidated by means of Fourier traiisfonn infrared spectroscopy(FTIR),1H NMR,13C NMR,and electrospray ionization mass spectroscopy(ESI-MS).A content determination method was established by ultraviolet detection.The lipophilicity,2,2-diphenyl-l-picrylhydrazy free radical(DPPH)scavenging capacity,anti-coagulant eitects,anti-bacterial activity,cytotoxicity,in vitro anti-proliterative activity against tumour cells,and the ability of the compounds to promote the proliferation of chondrocytes were evaluated.The results indicate that CSs exliibit strong DPPH scavenging activity,high lipophilicity,good anti-coagulant activities,wide anti-bacterial activity range,low cytotoxicity,and an excellent ability to promote chondrocyte proliferation. | PENG Xiaoyu ZHAO Anran HUANG Kelin HU Tingju LIU Burning HUANG Yan CHEN Hailan CHAI Ling LIN Cuiwu | 2020 | Chemical Research in Chinese Universities2020，36，5： | 0 |
| 15 | Hunger extends lifespan by modulating histone proteins显示文摘In a recent study published in Science,Weaver et al.provided insights into the effects of hunger on longevity.Inducing a state of hunger,either through restricting isoleucine intake or by stimulating R50H05 hunger neurons,resulted in an extension of lifespan in fruit flies.This effect is mediated by the modula-tion of histone proteins in the brain. | Hailan Liu Hongjie Li Yong Xu | 2023 | Life Metabolism2023，2，4： | 0 |
| 16 | The effects of cement density and pipe dimension on casing waves in oil wells显示文摘当时,一个 cased 洞里的声学的地通过由联合实验测量的数字建模被学习第一并且 scond 接口被结合很好。casing 到达(ACA ) 的振幅上的钢管子的水泥,直径和厚度的密度的效果被调查,并且数字结果的部分与试验性的结果相比。这些结果证明 ACA 与水泥的增加的密度减少。在那里存在为低密度、正常密度的水泥的 ACA 之间的大差别。因此,不同标准应该与不同密度为水泥在结合的评估被拿。当当它的直径作为一个常数保留时,钢管子的厚度增加, casing 波浪的到达时间仍然保持不变,当 ACA 增加时。但是当有经常的厚度的管子的直径增加时,波浪被推迟的 casing 的到达时间,和 ACA 减少。至于通常在油矿使用的三种钢管子, casing 到达的相对振幅在大管子中是更大的。另外,总体上,有水泥的密度的 casing 到达的相对振幅的变化趋势的数字结果与试验性的一致。 | CHEN Dehu WANG Xiuming ZHANG Hailan WANG Dong WEI Tao LIU Liping | 2011 | Chinese Journal of Acoustics2011，30，1： | 0 |
| 17 | Anatomical variations of segmental bronchi based on big data of somatom definition flash CT显示文摘The aims of this study were to study the branching patterns of segmental bronchi using Somatom Definition Flash CT and explore the gender differences.10000 patients were enrolled.The three dimensional bronchial tree images were acquired using the syngovia post-processing workstation.The directions of travel,openings,and ramifications of the segmental bronchi were observed with the aid of three-dimensional reconstruction and CT virtual bronchoscopy,assisted with lung window images.The branching patterns of the segmental bronchi were then extensively determined and the ratio of the formation patterns of the segmental bronchial branches was statistically analyzed. | Javed Saeed Liu Hailan Mei Yixtuan Zhang Yi Liu Cheng Liu Shuwei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | A novel genomic prediction method combining randomized Haseman-Elston regression with a modified algorithm for Proven and Young for large genomic data显示文摘Computational efficiency has become a key issue in genomic prediction(GP) owing to the massive historical datasets accumulated. We developed hereby a new super-fast GP approach(SHEAPY) combining randomized Haseman-Elston regression(RHE-reg) with a modified Algorithm for Proven and Young(APY) in an additive-effect model, using the former to estimate heritability and then the latter to invert a large genomic relationship matrix for best linear prediction. In simulation results with varied sizes of training population, GBLUP, HEAPY|A and SHEAPY showed similar predictive performance when the size of a core population was half that of a large training population and the heritability was a fixed value, and the computational speed of SHEAPY was faster than that of GBLUP and HEAPY|A. In simulation results with varied heritability, SHEAPY showed better predictive ability than GBLUP in all cases and than HEAPY|A in most cases when the size of a core population was 4/5 that of a small training population and the training population size was a fixed value. As a proof of concept, SHEAPY was applied to the analysis of two real datasets. In an Arabidopsis thaliana F2 population, the predictive performance of SHEAPY was similar to or better than that of GBLUP and HEAPY|A in most cases when the size of a core population(2 0 0) was 2/3 of that of a small training population(3 0 0). In a sorghum multiparental population,SHEAPY showed higher predictive accuracy than HEAPY|A for all of three traits, and than GBLUP for two traits. SHEAPY may become the GP method of choice for large-scale genomic data. | Hailan Liu Guo-Bo Chen | 2022 | The Crop Journal2022，10，2： | 0 |
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