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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Effect of diode laser irradiation on root surfaces in vitro显示文摘 | Kreisler M A1 Haj H Daublander M | 2002 | J Clin Laser Med Surg2002，20，1： | 1 |
| 3 | Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planing显示文摘 | Kreisler M AI Haj H dHoedt B | 2005 | Lasers Surg Med2005，37，5： | 1 |
| 4 | Transgenic over expression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action 显示文摘 | Zabolotny J M Haj F G Kim Y B | 2004 | Biol Chem2004，279，24： | 1 |
| 5 | Elastohydrodynamic analysis of lip seals with micro undulations显示文摘 | HaJ Jam M Bonneau D | 2004 | J Engineering Tri?bology2004，218，： | 1 |
| 6 | Effect of cause-related marketing on attitudes and purchase intentions: the moderating role of cause in?volvement and donation size显示文摘 | HaJ Jat M M | 2003 | Journal of Nonprofit & Public Sector Marketing2003，11，1： | 1 |
| 7 | Evaluation of seprafilm and amniotic membrane as adhesion prophylaxis in mesh repair of abdominal wall hernia in rats显示文摘 | Haj M Waxsman I | 2000 | Eur Surg Res2000，32，2： | 1 |
| 8 | Transgenic overexpression of protein tyrosine phosphatase 1 B in muscle causes insulin resistance,but overexpression with leukocyte antigen-related phosphatase does not additively impare insulin action显示文摘 | Zabolotny J M Haj F G Kim Y B | 2004 | J Biol Chem2004，279，24： | 1 |
| 9 | Mechanotransduction of bone cellsin vitro:Mechanobiology of bone tissue显示文摘 | Mullender M El Haj A Yang Y | | 0，，： | 1 |
| 10 | Epidemiology of enterobacteriaceae producing CTX-M type extended spectrum -lactamase (ESBL) 显示文摘 | Lahlaour H Ben Haj Khalifa A Ben Moussa M | 2014 | Mdecine et Maladies In f ectieuses2014，44，9： | 1 |
| 11 | Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planning显示文摘 | Kreisler M A1 Haj H d' Hoedt B | 2005 | Lasers Surg Med2005，37，4： | 1 |
| 12 | Accuracy of ultrasonography in confirmation of adequate reduction of distal radius fractures显示文摘 | Esmailian M Haj Zargarbashi E Masoumi B | 2013 | Emerg(Tehran)2013，1，1： | 1 |
| 13 | Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells显示文摘 | NACHSHON-KEDMI M YANNAI S HAJ A | 2003 | Food Chem Toxicol2003，41，： | 1 |
| 14 | Globular domain of adiponectin promising target molecule for detection of athero- sclerotic lesions显示文摘 | Almer G Saba - Lepek M Haj - Yahya S | 2011 | Biologics2011，5，： | 1 |
| 15 | Membranous fat necrosis of the breast:diagnosis by minimally invasive technique显示文摘 | Haj M Loberant N Salamon V | 2004 | Breast J2004，10，6： | 1 |
| 16 | Tmnsanal irriga- tions in the management of bowel dysfunction and disordered defecation after spinal cord injury 显示文摘 | Fourtassia M Chanriem K Haj]iouib A | 2011 | Proq Urol2011，22，8： | 1 |
| 17 | Modeling and Simulation of Erosion-Corrosion in Disturbed Two-Phase Flow Through Fluid Transport Pipelines显示文摘 | Okhovat A Zeinali Heris S Haj Asgarkhani M A | 2014 | Arabian Journal for Science and Engineering2014，39，3： | 1 |
| 18 | Isola- ted primary gastric localization of a mantle cell lymphoma 显示文摘 | Bel Haj Salah M Ben Brahim E Zidi Y Si | 2010 | Ann Pathol2010，30，4： | 1 |
| 19 | Variation in leaf traits through seasons and N-availability levels and its consequences for ranking grassland species显示文摘 | A1 Haj Khaled R Duru M Theau JP | | 0，，： | 1 |
| 20 | ANP and BNP responses to de- hydration in the one-humped camel and effects of blocking the re- nin-angiotensin system 显示文摘 | Adem A A1 Haj M Benedict S | 2013 | PLoS One2013，8，57： | 1 |
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