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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Fruit component analysis of south Pacific coconut palm populations显示文摘 | Ashburner G R Thompson W K Halloran G M | 1977 | Genetic Resources and Crop Evolution1977，44，： | 1 |
| 3 | Alpha alumina formation in alum-derived gama alumina显示文摘 | Halloran W | 1982 | Journal of Amerian Ceramic Socie-ty1982，65，9： | 1 |
| 4 | 显示文摘 | Araki K Halloran J W | 2005 | J Am Ceram Soc2005，88，50： | 1 |
| 5 | Crack deflection and propagation in layered silicon nitride/boron nitride ceramics 显示文摘 | KOVAR D THOULESS M D HALLORAN I W | 1998 | J Am Ceram Soc1998，81，4： | 1 |
| 6 | RAPD analysisof South pacific coconut palm poulation显示文摘 | Ashburner G R Thompson W R Halloran G M | 1997 | Crop Science1997，37，3： | 1 |
| 7 | 显示文摘 | Baskaran S Halloran J W | 1993 | J Am Ceram Soc1993，76，9： | 1 |
| 8 | RAPD analysis of South pacific coconut palm poulation 显示文摘 | Thompson W R Halloran G M | 1997 | Cropscience1997，37，3： | 1 |
| 9 | 显示文摘 | Baskaran S Halloran J W | 1994 | J Am Ceram Soc1994，77，5： | 1 |
| 10 | Curing of high-loading ceramic suspension in acrylates 显示文摘 | GABRIEL T M HALLORAN J W | 2000 | J Am Ceram Soc2000，83，10： | 1 |
| 11 | Crack deflection and propagation in layered silicon nitride/boron nitride ceramics 显示文摘 | Kovar D Thouless M D Halloran J W | 1998 | J Am Ceram Soc1998，81，4： | 1 |
| 12 | 显示文摘 | Baskaran S Halloran J W | 1994 | J Am Ceram Soc1994，77，5： | 1 |
| 13 | 显示文摘 | Trice R W Halloran J W | 1999 | J Am Ceram Soc1999，82，11： | 1 |
| 14 | Processing and sintering of ultrafine MgO-ZrO2and (MgO,Y2O3)-ZrO2 powders显示文摘 | READY M J LEE R R HALLORAN J W | 1990 | J Amer CeramicSoc1990，73，6： | 1 |
| 15 | Fibrous monolithic ceramics: III,mechanical properties and oxidation behavior of the silicon carbide/boron nitride system显示文摘 | Suresh Baskaran John W Halloran | 1994 | J Am Ceram Soc1994，77，5： | 1 |
| 16 | Insulin-like growth factor-I is essential for embryonic bone development显示文摘 | Wang Y Nishida S Sakata T Elalieh HZ Chang W Halloran BP Doty SB Bikle DD | | 0，，： | 1 |
| 17 | Flow behavior of polymerizable ceramic suspensions as function of ceramic volume fraction and temperature 显示文摘 | Tomeckova V Halloran J W | 2011 | J Europ Ceram Soc2011，31，： | 1 |
| 18 | Fruit component analysis of south Pacific coconut palm populations显示文摘 | Ashburner G R Thompson W K Halloran G M | 1977 | Genetic Resources and Crop Evolution1977，44，4： | 1 |
| 19 | An economic analysis of potential rotation crops for Ma- ine potato cropping systems 显示文摘 | HALLORAN J M GRIFFIN T S HONEYCUTr C W | 2005 | American Journal of Potato Research2005，82，2： | 1 |
| 20 | Fruit component analysis of south Pacific coconut palm populations显示文摘 | ASHBURNER G R THOMPSON W K HALLORAN G M FAALE M A | 1997 | Genetic Resources and Crop Evolution1997，44，： | 1 |
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