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| 1 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 2 | Value of adiponectin as predictor of 5-year all-cause mortality in patients with symptomatic pe- ripheral arterial disease: results from the Linz Peripheral Arterial Dis- ease (LIPAD) study显示文摘 | Dieplinger B Haltmayer M Poelz W | 2009 | Clin Chim Acta2009，408，12： | 1 |
| 3 | HypoAdiponectininemia is associated with symptomatic atherosclerotic peripheral arterial disease 显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 4 | Hypoadiponectinemia is associated with symptonmtic atherosclerotic peripheral arterial disease显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 5 | Long-term stability of endogenous B-type natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) in frozen plasma samples显示文摘 | Thomas Mueller Alfons Gegenhuber Benjamin Dieplinger Werner Poelz Meinhard Haltmayer | 2004 | Clinical Chemistry and Laboratory Medicine2004，，8： | 1 |
| 6 | Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 7 | Association of adiponectin and amino terminal proBNP in peripheral arterial disease显示文摘 | DIEPLINGER B POELZ W HALTMAYER M | 2007 | Clin Chim Acta2007，377，12： | 1 |
| 8 | Evaluationof novel biomarkers for the diagnosis of acute destabilised heartfailure in patients with shortness of breath显示文摘 | Dieplinger B Gegenhuber A Haltmayer M | 2009 | Heart2009，95，18： | 1 |
| 9 | Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath 显示文摘 | Dieplinger B Gegenhuber A Haltmayer M | 2009 | Heart2009，95，18： | 1 |
| 10 | Biochemical diagnosis of impaired left ventricular ejection fraction--comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP)显示文摘 | Mueller T Gegenhuber A Poelz W Haltmayer M | 2004 | Clin Chem Lab Med2004，42，2： | 1 |
| 11 | Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath 显示文摘 | Dieplinger B Gegenhuber A Haltmayer M | 2009 | Heart2009，95，18： | 1 |
| 12 | Monitoring aspirin 100 mg and clopidogrel 75 mg therapy with the PFA-100 device in patients with peripheral arterial disease显示文摘 | Haltmayer M Poelz W | 2003 | Vasc Endovascular Surg2003，37，2： | 1 |
| 13 | Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease显示文摘 | DIEPLINGER B POELZ W HALTMAYER M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 14 | Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath显示文摘 | DIEPLINGER B GEGENHUBER A HALTMAYER M | 2009 | Heart2009，95，18： | 1 |
| 15 | Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma显示文摘 | Benjamin Dieplinger Margot Egger Christian Gabriel Werner Poelz Elisabeth Morandell Beata Seeber Florian Kronenberg Meinhard Haltmayer Thomas Mueller Hans Dieplinger | 2013 | Clinica Chimica Acta2013，，： | 1 |
| 16 | Comparative Evaluation of B-Type Natriuretic Peptide, Mid-Regional Pro-A-type Natriuretic Peptide, Mid-Regional Pro-Adrenomedullin, and Copeptin to Predict 1-Year Mortality in Patients With Acute Destabilized Heart Failure显示文摘 | Alfons Gegenhuber Joachim Struck Benjamin Dieplinger Werner Poelz Richard Pacher Nils G. Morgenthaler Andreas Bergmann Meinhard Haltmayer Thomas Mueller | 2007 | Journal of Cardiac Failure2007，，： | 1 |
| 17 | Comparative Evaluation of B-Type Natriuretic Peptide, Mid-Regional Pro-A-type Natriuretic Peptide, Mid-Regional Pro-Adrenomedullin, and Copeptin to Predict 1-Year Mortality in Patients With Acute Destabilized Heart Failure显示文摘 | Alfons Gegenhuber Joachim Struck Benjamin Dieplinger Werner Poelz Richard Pacher Nils G. Morgenthaler Andreas Bergmann Meinhard Haltmayer Thomas Mueller | 2007 | Journal of Cardiac Failure2007，，1： | 1 |
| 18 | Increased soluble ST2 predicts long-term mortality in patients with stable coronary artery disease:results from the Ludwigshafen risk and cardiovascular health study显示文摘 | Dieplinger B Egger M Haltmayer M | 2014 | Clin Chem2014，60，3： | 1 |
| 19 | Hypoadiponectinemia is asso- ciated with symptomatic atherosclerotic peripheral arterial disease 显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Ciin Chem Lab Med2006，44，7： | 1 |
| 20 | Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath 显示文摘 | Dieplinger B Gegenhuber A Haltmayer M | 2009 | Heart2009，95，18： | 1 |
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