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| 1 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 3 | Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium显示文摘 | Vishnudutt Purohit J. Christian Bode Christiane Bode David A. Brenner Mashkoor A. Choudhry Frank Hamilton Y. James Kang Ali Keshavarzian Radhakrishna Rao R. Balfour Sartor Christine Swanson Jerrold R. Turner | 2008 | Alcohol2008，，5： | 3 |
| 4 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 5 | A New Approach to the Economic Analysis of Nonstationary Time Series and the Business Cycle显示文摘 | Hamilton James D | 1989 | Econometrica1989，57，： | 1 |
| 6 | A new approach to the economic analysis of nonstationary time series and the business cycle 显示文摘 | Hamilton James | 1989 | Econometrica1989，，57： | 1 |
| 7 | The mechanical properties of 316L/304L stainless steels, Alloy 718 and Mod 9Cr-1Mo after irradiation in a spallation environment 显示文摘 | Maloy S A James M R Willcutt G Sommer W F Sokolov M Snead L L Hamilton M L Garner F | 2001 | Journal of Nuclear Material2001，296，： | 1 |
| 8 | NMR reveals molecular interactions and dynamics of fatty acid binding to albumin显示文摘 | James A. Hamilton | 2013 | BBA - General Subjects2013，，12： | 1 |
| 9 | Monitoring aircraft usage of the marine park: a case study from Whitehaven Beach 显示文摘 | Mary Hamilton James Innes | 1999 | Whitsunday Island1999，9，2： | 1 |
| 10 | In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent显示文摘 | René M. Botnar Alexandra S. Perez Sonia Witte Andrea J. Wiethoff James Laredo James Hamilton William Quist Edward C. Parsons Anand Vaidya Andrew Kolodziej John A. Barrett Philip B. Graham Robert M. Weisskoff Warren J. Manning Michael T. Johnstone | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 1 |
| 11 | A new approach to the economic analysis of non-stationary time series and the business cycle显示文摘 | Hamilton James D | 1989 | Econometrica1989，57，2： | 1 |
| 12 | Dust control u- sing exhaust ventilation techniques in UK coal mines 显示文摘 | Hamilton R J French A G James G C | 1980 | Journal of Mathematical Analysis and Applica- tions1980，7，1： | 1 |
| 13 | Early-Life Sodium Exposure Unmasks Susceptibility to Stroke in Hyperlipidemic, Hypertensive Heterozygous Tg25 Rats Transgenic for Human Cholesteryl Ester Transfer Protein显示文摘 | Julius L. Decano Jason C. Viereck Ann C. McKee James A. Hamilton Nelson Ruiz-Opazo Victoria L.M. Herrera | 2009 | Circulation2009，，11： | 1 |
| 14 | Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer显示文摘 | Peter C O’Brien Christopher S Hamilton James W Denham Ralph Gourlay C.Ian V Franklin | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，1： | 1 |
| 15 | On the Limitation of Government Borrowing:A Frame work for Empirical Testing显示文摘 | Hamilton James D Marjorie Flavin | | 0，，176： | 1 |
| 16 | Analysis of Anal Droplets of the Western Flower Thrips Frankliniella occidentalis显示文摘 | Kenneth M. MacDonald James G. C. Hamilton Robert Jacobson William D. J. Kirk | 2003 | Journal of Chemical Ecology2003，，10： | 1 |
| 17 | Nonlinearities and the Macroeconomic Effects of Oil Prices显示文摘 | Hamilton James D | 1983 | Macroeconomic dynamics1983，15，3： | 1 |
| 18 | Pollution as News: Media and Stock Market Reactions to the Toxics Release Inventory Data 显示文摘 | Hamilton James T | 1995 | Journal of Environmental Economics and Management1995，28，3： | 1 |
| 19 | Comparing silvopastoral systems and prospects in eight regions of the world显示文摘 | Frederick Cubbage Gustavo Balmelli Adriana Bussoni Elke Noellemeyer Anibal N. Pachas Hugo Fassola Luis Colcombet Belén Rossner Gregory Frey Francis Dube Marcio Lopes Silva Hayley Stevenson James Hamilton William Hubbard | 2012 | Agroforestry Systems2012，，3： | 1 |
| 20 | A New Approach to the Economic Analysis of Nonstationary Time Series and the Business Cyele显示文摘 | James D Hamilton | 1989 | Eeonometriea1989，57，2： | 1 |
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