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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 3 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 4 | Lead tetrakis(imidazotyt)borate solids: anion exchange, sol- vent intercalation, and self assembly of an organic anion 显示文摘 | HAMILTON B H KELLY K A WAGLER T A | 2004 | Inorg Chem2004，43，1： | 1 |
| 5 | Metal injec- tion moulding of CP-Ti components for biomedical applica- tions显示文摘 | Sidambe A T Figueroa I A Hamilton H | 2012 | J Mater Process Teehnol2012，212，： | 1 |
| 6 | The roles of the Hadley circulation and downward control in tropical upwelling显示文摘 | Zhou T Geller M A Hamilton K | 2006 | Journal of the Atmospheric Sciences2006，63，： | 1 |
| 7 | Granulocyte-macrophage colony-stimulating factor(CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles end transcription factor activities:implications for CSF blockade in inflam- mation显示文摘 | Fleetwood A J Lawrence T Hamilton JA et a 1 | 2007 | J Immunol2007，178，8： | 1 |
| 8 | LPS induces altered phosphate labeling of proteins in murine peritoneal macrophages显示文摘 | WEIEL J E HAMILTON T A ADAMS D O | 1986 | J Immunol1986，136，8： | 1 |
| 9 | Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications 显示文摘 | HAMILTON D W MAUL T M VORP D A | 2004 | Tissue Eng2004，10，34： | 1 |
| 10 | An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus显示文摘 | Dalmay T Hamilton A Rudd S | 2000 | Cell2000，101，： | 1 |
| 11 | Variation of rate during potassium-catalysed CO2 gasification of coal char显示文摘 | Hamilton R Sams T Shadman D A | 1984 | Fuel1984，63，1： | 1 |
| 12 | Irradiation detection 显示文摘 | Stevenson M H Crone A V J Hamilton J T G | 1990 | Nature1990，344，： | 1 |
| 13 | Acylation ofAlkyl Ferrocenecarboxylates:An Approach to Unsym- metrical 1,1 ' - Disubstituted Ferrocene Derivatives and Bridged Metallocene Receptors 显示文摘 | Grossel C M Hamilton G D Vine A T | 1997 | Tetrahedron Letters1997，38，26： | 1 |
| 14 | Requirement for STAT1 in LPS-induced gene expression in macrophages 显示文摘 | Ohmori Y Hamilton T A | 2001 | J Leukoc Biol2001，69，4： | 1 |
| 15 | Effect of storage and cooking on the dose response of 2 - dodecylcyclobutanone, a potential marker for irradiated chicken显示文摘 | Crone A V J Hamilton J T G | 1992 | J Sci Food Agric1992，58，： | 1 |
| 16 | XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41 显示文摘 | ZHAO Q EMST J T HAMILTON A D | 2002 | A/DS Res Hum Retroviruses2002，18，14： | 1 |
| 17 | The detection of 2 - dodecylcy-clobutanone in radiation - sterilised chicken stored for several years 显示文摘 | Crone A V J Hamilton J T G | 1992 | Int J Food Sci Technol1992，27，： | 1 |
| 18 | Influence of fluoride on aluminum toxicity to Atlantic salmon(Salmo salar)显示文摘 | Hamilton S J Haines T A | 1995 | Canadian Journal of Fisheries and Aquatic Science1995，52，24： | 1 |
| 19 | An RNA-dependent RNA polymerase gene in Arabidopsis is requires for posttranscriptional gene silencing mediated by a transgene but not by a virus显示文摘 | Dalmay T Hamilton A Rudd S | 2000 | Cell2000，101，： | 1 |
| 20 | Metal injection moulding of CP-Ti components for biomedical applications 显示文摘 | Sidambe A T Figueroa I A Hamilton H G C | 2012 | Journal of Materials Processing Technology2012，212，7： | 1 |
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