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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Application of grid-based molecular methods for modeling solvent-dependent crystal growth morphology: Aspirin crystallized from aqueous ethanolic solution显示文摘 | Hammond R B Pencheva K Ramachandran V | 2007 | Cryst Growth Des2007，7，9： | 1 |
| 3 | A Semiconducting Metal-Oxide Array for Monitoring Fish Freshness显示文摘 | Hammond J Marquis B B Michaels R et a1 | 2002 | Sensors and Actuators B2002，，84： | 1 |
| 4 | Expression of the rabies virus glycoprotein in Transgenic Tomatoes 显示文摘 | Peter B Mc Garvey John Hammond | 1995 | Bio/Technology1995，13，： | 1 |
| 5 | Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit mode 显示文摘 | Muhlestein J B Anderson J L Hammond E H | 1998 | Circulation1998，97，： | 1 |
| 6 | The identification of a patent, water soluble inhibitor of lipoprotei-associated phospholipase A2 显示文摘 | Boyd HF Hammond B Hiekey DMB | 2001 | Bioorg Med Chem Lett2001，11，5： | 1 |
| 7 | Higher - order spectra: the bispectrum and trispeetrum 显示文摘 | COLLIS W B WHITE P R HAMMOND J K | 1998 | Mechanical System and Signal Processing1998，12，3： | 1 |
| 8 | Integrating diverse information resources in a case-based design environment 显示文摘 | Leake D B Birnbaum L Hammond K | 1999 | Engineering Applications of Artificial Intelligence1999，12，6： | 1 |
| 9 | Expression of the rabies virus glycoprotein in transgenic tomatos 显示文摘 | McGarvey P B Hammond J Dienelt M M | 1995 | Bio/Tech-nology1995，13，： | 1 |
| 10 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B | 1979 | Geoehim Cosmoehim Acta1979，43，7： | 1 |
| 11 | Tracking Spore-Forming Bacterial Contaminants in Fluid Milk-Processing Sys- tems 显示文摘 | HUCK J R HAMMOND B H MURPHY S C | 2007 | Journal of Dairy Science2007，90，： | 1 |
| 12 | Crystal structures and properties of nylon polymers from theory 显示文摘 | DASGUPTA S HAMMOND W B GODDARD W A | 1996 | Journal of the American Chemical Society1996，11，12： | 1 |
| 13 | Results of a 90-daysafety assurance study with rats fed grain from corn borer-protectedcorn显示文摘 | Hammond B G Dudek R Lemen J K | 2006 | Food and Chemical Toxicology2006，44，7： | 1 |
| 14 | Identification of adhesions on CT in small-bowel obstruction 显示文摘 | Petrivic B Nikolaidis P Hammond NA | 2006 | Emerg Radiol2006，12，3： | 1 |
| 15 | Molecular modelling of the morphology of organic crystals in the presence of impurity species: Recent applications to naphthalene, phenanthrene, and caprolactam crystals显示文摘 | Clydesdale G Hammond R B Ramachandran V | 2005 | Molecular Crystals and Liquid Crystals2005，440，1： | 1 |
| 16 | Vitamin A Degradation and Light-Oxidized Flavor Defects in Milk 显示文摘 | WHITED L J HAMMOND B H CHAPMAN K W | 2002 | J Dairy Sci2002，85，： | 1 |
| 17 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B Maynard V | 1979 | Geochim Cosmochim Acta1979，43，7： | 1 |
| 18 | Quantifying solubility enhancement due to particle size reduction and crystal habit modification: case study of acetyl salicylic acid 显示文摘 | HAMMOND R B PENCHEVA K ROBERTS K J | 2007 | J Pharm Sci2007，96，： | 1 |
| 19 | Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5communities in North America 显示文摘 | Peret T C Hall C B Hammond G W | 2000 | J Infect Dis2000，181，： | 1 |
| 20 | Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat显示文摘 | Hammond C Rouzaire-Dubois B Feger J | 1983 | Neuroscience1983，9，1： | 1 |
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