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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Equilibrium existence in the circle model with linear quadratic transport cost显示文摘 | de Frutos M A Hamoudi H Jarque X | 1999 | Regional Science and Urban Economics1999，29，5： | 1 |
| 3 | Equilibrium existence in the linear model: concave versus convex transportation costs显示文摘 | Hamoudi H Moral M J | 2005 | Papers in Regional Science2005，84，2： | 1 |
| 4 | Beads made of cyclodextrin and oil for the oral delivery of lipophilic drugs: In vitro studies in simulated gastro-intestinal fluids 显示文摘 | Hamoudi M C Fattal E Gueutin C | 2011 | Int J Pharm2011，416，2： | 1 |
| 5 | Formulations based on alpha cyclodextrin and soybean oil: An approach to modulate the oral release of lipophilic drugs 显示文摘 | Hamoudi M C Bourasset F Domergue-Dupont V | 2012 | J Controlled Release2012，161，3： | 1 |
| 6 | Problem based learning and its impact on learning behavior of pharmacy students in RAK medical and health sciences university 显示文摘 | HAMOUDI N M NAGAVI B G AL-AZZAWI A M J | 2010 | Indi J Pharm Educ Res2010，44，3： | 1 |
| 7 | Geoforschungs zentrum anomaly magnetic map (GAMMA) : candidate model for the WDMAM 显示文摘 | Hamoudi M Thebauh E Lesur V | 2007 | Geophysical Research Abstracts2007，9，08： | 1 |
| 8 | Adsorptive re moval of nitrate and phosphate anions from aqueous solutions using functionalized SBA-15:Effects of the organic functional group 显示文摘 | Hamoudi A E Nemr M Bouguerra K | 2012 | The Canadian Journal of Chemical Engineering2012，90，： | 1 |
| 9 | Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus显示文摘 | Simon-Loriere E Galetto R Hamoudi M | | 0，，： | 1 |
| 10 | Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus显示文摘 | Simon-Loriere E Galetto R Hamoudi M | 2009 | PLoS Pathog2009，5，10： | 1 |
| 11 | 2010, International geomagnetic re显示文摘 | Finlay C C Maus S Beggan C D Bondar T D Chambodut A Chernova T A Chulliat A Golovkov V P Hamilton B Hamoudi M Holme R Hi]lot G Kuang W Langlais B Lesur V Lowes F J Luhr H Macmillan S Mandea M Mclean S Manoj C Menvielle M Michaelis I Olsen N Rauberg J Rother M Sabaka T J Tangborn A W P Toffner-Clausen L Thfibault E Thomson A Wardinski I Wei Z Zvereva T | 2010 | Geophys J Int2010，183，3： | 1 |
| 12 | Beads made of cyclo- dextrin and oil for the oral delivery of lipophilic drugs: in vitro studies in simulated gastro-intestinal fluids 显示文摘 | Hamoudi M C Fattal E Gueutin C | 2011 | Int J Pharm2011，416，2： | 1 |
| 13 | Interactions between cyelodextrins and triglyeerides: from emulsion stabilisation to the emergence of a new drug delivery system called ' beads' 显示文摘 | Hamoudi M Trichard L Grossiord J | 2009 | Ann Pharm Fr2009，67，6： | 1 |
| 14 | Formu- lations based on alpha cyelodextrin and soybean oil:an approach to modulate the oral release of lipophilie drugs显示文摘 | Hamoudi M C Bourasset F Domergue-Dupont V | 2012 | J Control Re- lease2012，161，3： | 1 |
| 15 | Is the presence of He- licobacter pylofi in the dental plaque of patients with chronic peri- odontitis a risk factor for gastric infection显示文摘 | A1 Asqah M A1 Hamoudi N Anil S | 2009 | Can J Gastroenterol2009，23，3： | 1 |
| 16 | Equilibrium existence in the linear model: concave versus convex transportation costs 显示文摘 | Hamoudi H Moral M J | 2005 | Papers in Regional Science2005，，84： | 1 |
| 17 | Spatial competition with concave transport costs显示文摘 | Hamoudi H | 2002 | Regional Science and Urban Economics2002，32，： | 1 |
| 18 | Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus显示文摘 | Simon-Loriere E Galetto R Hamoudi M | 2009 | PLoS Pathog2009，5，10： | 1 |
| 19 | 1-Butanol etherification over sulfonated mesostructured silica and organo-silica 显示文摘 | Bineta Sow Safia Hamoudi M Hassan Zahedi-Niaki | 2005 | Microporous and Mesoporous Materials2005，79，： | 1 |
| 20 | Equilibrium existence in the circle model with linear quadratic transport cost显示文摘 | de Frutos M A Hamoudi H Jarque X | 1999 | Regional Science and Urban Economics1999，29，5： | 1 |
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