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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013,19,39: | 9 |
| 2 | Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system显示文摘 | Strappe P M Hampton D W Begona C G | 2005 | Eur J Pharm Biopharm2005,61,3: | 1 |
| 3 | Visual prognosis of disciformdegeneration inmyopia显示文摘 | Hampton GR Kohen D Bird AC | 1983 | Ophthalmology1983,90,8: | 1 |
| 4 | Visual prognosis of disciform degeneration in myopia显示文摘 | Kohen D Bird AC | 1983 | Ophthalmology1983,90,: | 1 |
| 5 | Biomeehanieal properties of threaded inserts for lumbar interbody显示文摘 | Teneer AF Hampton D Eddys | 1995 | Spine1995,22,6: | 1 |
| 6 | The excitation of UHF signals by partial discharges in GIS显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996,3,2: | 1 |
| 7 | The apelin receptor in- hibits the augiotensin II type 1 receptor via allosteric trans - inhibition 显示文摘 | Siddiquee K Hampton J McAnally D | 2013 | BrJPharmacol2013,168,5: | 1 |
| 8 | Water deficit effects on the cotton leaf cutile and the efficiency of defoliants显示文摘 | OOSTERHUIS D M Hampton R E Wullschleger S D | 1991 | J Prod Agric1991,4,: | 1 |
| 9 | Excitation of UHF signals by partial discharge in GIS显示文摘 | Judd M D Farish O Hampton B F | 1996 | IEEE Trans on Dielectrics and Electrical Insulation1996,3,2: | 1 |
| 10 | Biomechanieal properties of threaded inserts for lumbar interbody fusion显示文摘 | Teneer AF Hampton D Eddy S | 1995 | Spine1995,20,22: | 1 |
| 11 | The excitation of UHF signals by partial discharges in GIS显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996,3,2: | 1 |
| 12 | Imagery and the interpretation of ambiguous noun-noun combinations显示文摘 | Hampton J.A Francis D Robson G | | 0,,02: | 1 |
| 13 | Visual prognosis of disciform degeneration in myopia显示文摘 | Hampton GR Kohen D Bird AC | 1983 | Ophthalmology1983,90,: | 1 |
| 14 | The excitation of UHF signals by partial discharge in GIS显示文摘 | Judd M D Farish O Hampton B F | 1996 | IEEE Trans on Dielectrics and Electrical Insulation1996,3,2: | 1 |
| 15 | Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1,HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vectors system with highly favorable features for in vivo testing and clinical usage显示文摘 | Strappe PM Hampton DW Brown D | | 0,,: | 1 |
| 16 | Androgen receptor mRNA expression in the bovine ovary显示文摘 | Hampton J H Manikkam M Lubahn D B | 2004 | Domestic Animal Endoerinol2004,27,1: | 1 |
| 17 | Effect of TixAly catalysts on hydrogen storage properties of LiAlH4 and NaAlH4显示文摘 | Mirna Resan Michael D Hampton Janice K Lomness | 2005 | Int J Hydrogen Energy2005,30,: | 1 |
| 18 | Hydrogen uptake characteristics of mechanically alloyed mixtures of Ti-Mg-Ni显示文摘 | Lomness J K Hampton M D Giannuzzi L A | 2002 | Intern J of Hydrogen Energy2002,27,9: | 1 |
| 19 | The Excitation of UHF Signals by Partial Discharges in GIS 显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996,3,2: | 1 |
| 20 | Healing potential of the annulus fibrosus 显示文摘 | Hampton D Laros G McCarron R | 1989 | Spine1989,14,4: | 1 |