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| 1 | Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement显示文摘White spot lesions(WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate(NACP) with long-term calcium(Ca) and phosphate(P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACPrechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release.The rechargeable cement consisted of pyromellitic glycerol dimethacrylate(PMGDM) and ethoxylated bisphenol A dimethacrylate(EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength(SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release(P40.1). Specimens after one recharge treatment(e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as '1 min 3 times') exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles(P40.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times43 min 2 times41 min 2 times46 min 1 time43 min 1 time41 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets. | Xian-Ju Xie Dan Xing Lin Wang Han Zhou Michael D Weir Yu-Xing Bai Hockin HK Xu | 2017 | International Journal of Oral Science2017，9，1： | 3 |
| 2 | Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory显示文摘 | Lee HK Takamiya K Han JS | 2003 | Cell2003，112，5： | 1 |
| 3 | Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy显示文摘 | Dressman HK Hans C Bild A | 2006 | Clin Cancer Res2006，12，3： | 1 |
| 4 | Prevalence and risk factors for aspirin and clopidogrel resistance in patients with coronary artery disease or ischemic eerebrovascular disease显示文摘 | Kim H Lee HK Han K | 2009 | Am Clin Lab2009，39，3： | 1 |
| 5 | Low-grade gastric nmcosa-associateed lymphoid tissue lymphoma:correlation of radiographic and pathologic findings显示文摘 | Kim YH Lim HK Han JK | 1999 | Radiology1999，212，1： | 1 |
| 6 | Serial ANCA titers:useful tool for prevention of relapses in ANCA-associated vasculitis显示文摘 | Han WK Choi HK Roth RM | | 0，，03： | 1 |
| 7 | Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus显示文摘 | Han YW Aleyas AG George JA Kim SJ Kim HK Yoo DJ Kang SH Eo SK | 2009 | Immunol Cell Biol2009，87，1： | 1 |
| 8 | Limitations of standard fluoroscopy in detecting rotational malreduction of thesyndesmosis in an ankle fracture model 显示文摘 | Marmor M Hanson E Han HK | 2011 | Foot Ankle Int2011，32，6： | 1 |
| 9 | Feasibility of a laparoscopic approach for generalized peritonitis from perforated appendicitis in children显示文摘 | Chang HK Han SJ Choi SH | 2013 | Yonsei Med J2013，54，6： | 1 |
| 10 | Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis显示文摘 | Han WK Choi HK Roth RM | 2003 | Kidney Int2003，63，3： | 1 |
| 11 | Differential, stage-dependent expres- sion of Hsp70, Hspl 10 and Bcl-2 in colorectal cancer显示文摘 | Hwang TS Han HS Choi HK | 2003 | J Gastroenterol Hepatol2003，18，6： | 1 |
| 12 | Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory 显示文摘 | Lee HK Takamiya K Han JS | 2003 | Ce112003，112，： | 1 |
| 13 | Epidemiologic update on the dengue situation in the Western Pacific Region, 2011 显示文摘 | Arima Y Edelstein ZR Han HK | 2013 | Wester Pac Surveill Resporse J2013，4，2： | 1 |
| 14 | Pyruvate kinase isozymetype M2(PKM2)interacts and cooperates with Oct-4 inregulating transcription显示文摘 | Lee J Kim HK Han YM | 2008 | Int J Biochem Cell Biol2008，40，： | 1 |
| 15 | Direct enantiomer separaL tion of thyroxine in pharmaceuticals using crown ether type chiral stationary phase 显示文摘 | Jeon SH Kim M Han HK | 2010 | Arch Pharm Res2010，32，9： | 1 |
| 16 | 1-Bromopropane up-regulates cyclooxygenase-2 expression via NF-KB and C/EBP activation in murine macrophages 显示文摘 | Han EH Yang JH Kim HK | 2012 | Food Chem Toxicol2012，50，5： | 1 |
| 17 | Modulation of laboratory parameters ager therapeatic and prophylactic administration of Sandoparin 显示文摘 | Hoppensteadt DA Hans K Breddin HK | 1993 | Semin Thromb Hemost1993，19，1： | 1 |
| 18 | Serial ANCA titers:useful tool for prevention of relapses in ANCA-aasociated vasculitis 显示文摘 | Han WK Choi HK Roth RM | 2003 | Kidney lnt2003，63，3： | 1 |
| 19 | Analysis of sterilization effect by pulsed dielectric barrier discharge 显示文摘 | Choi JH Han I Balk HK | 2006 | J Electrostatic2006，64，1： | 1 |
| 20 | Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation显示文摘 | Nepal PIK Han HK Choi HK | 2010 | IntJ Pharm2010，383，12： | 1 |
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