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| 1 | Management of early gastrointestinal neuroendocrine neoplasms显示文摘Neuroendocrine neoplasms (NENs) of the stomach, duo- denum, appendix or rectum that are small (≤ 1 cm) and well differentiated can be considered 'early' tumors, since they generally have a (very) good prognosis. In the new WHO classification of 2010, these neoplasms are called neuroendocrine tumors/ carcinoids (NETs), grade (G) 1 or 2, and distinguished from poorly differentiated neuroendocrine carcinomas (NECs), G3. NETs are increasing, with a rise in the age-adjusted incidence in the U.S.A. by about 700 % in the last 35 years. Improved early detection seems to be the main reason for these epidemiological changes. Both the better generalavailability of endoscopy, and imaging techniques, have led to a shift in the discovery of smaller-sized (≤ 10-20 mm) intestinal NETs/carcinoids and earlier tumor stages at diagnosis. Endoscopic screening is therefore effective in the early diagnosis, not only of colorectal adenocarcinomas, but also of NETs/carcinoids. Endoscopic removal, followed up with endoscopic surveillance is the treatment of choice in NETs/carcinoids of the stomach, duodenum and rectum that are ≤ 10 mm in size, have a low proliferative activity (G1), do not infiltrate the muscular layer and show no angioinvasion. In all the other intestinal NENs, optimal treatment generally needs surgery and/or medical therapy depending on type, biology and stage of the tumor, as well as the individual situation of the patient. | Hans Scherübl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Günter Klppel | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 13 |
| 2 | Neuroendocrine tumors of the small bowels are on the rise:Early aspects and management显示文摘Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of the duodenum are detected 'incidentally' and therefore recognized at an early stage. Duodenal NETs which are well differentiated,not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm,for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management,tumor biology,type,localization and stage of the neoplasm,as well as the patient's individual circumstances have to be taken into account. | Hans Scherbl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Gnter Klppel | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，10： | 10 |
| 3 | Neuronal differentiation of embryonic mid- brain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway 显示文摘 | Park KS Lee RD Kang SK Han SY Park KL Yang KH | 2004 | Exp Cell Res2004，297，2： | 1 |
| 4 | Value of C-telopeptide-cross-linked Type I collagen,osteocalcin,bone-specific alkaline phosphatase and procollagen Type I N-terminal propeptide in the diagnosis and prognosis of bone metastasis in patients with malignant tumors显示文摘 | Zhao H Han KL Wang ZY | 2011 | Med Sci Monit2011，17，11： | 1 |
| 5 | Protective Effects of Panduratin A against Oxidative Damage of tert-Butylhydroperoxide in Human HepG2 Cells显示文摘 | Sohn JH Han KL Lee SH | 2005 | Biol Pharm Bull2005，28，： | 1 |
| 6 | Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease显示文摘 | Choi YM Shim KS Yoon KL Han MY Cha SH Kim SK | 2012 | Korean J Pediatr2012，55，1： | 1 |
| 7 | Antimicrobial effects ofcorn zein films impregnated with nisin, lauric acid,and EDTA显示文摘 | HOFFMAN KL’HAN IY DAWSON PL | 2001 | J Food Protect2001，64，6： | 1 |
| 8 | Minocycline markedly protects the neonatal brain against hypoxic - ischemic injury 显示文摘 | Arvin KL Han BH Du Y | 2002 | Ann Neurol2002，52，9： | 1 |
| 9 | Structural basis of integrin activation by talin 显示文摘 | WEGENGER KL PARTRIDGE AW HAN J | 2007 | Cell2007，128，1： | 1 |
| 10 | Selective vulnerability of late oligodendrecyte progenitors to hypoxia-ischemia显示文摘 | Back SA Han BH Luo NL Chrieton CA Xanthoudakis S Tam J Arvin KL Holtzman DM | 2002 | J Neurosci2002，22，2： | 1 |
| 11 | Evaluation of a digene-recommended algorithom for human papillomavirus lowpositive result present in a'retest zone'显示文摘 | Muldrew KL Beqaj SH Han J | 2007 | Am J Clin Pathol2007，127，1： | 1 |
| 12 | Evaluation of a digene-recommended algorithm for human papillomavirus low-positive results present in a 'Retest Zone' 显示文摘 | Muldrew KL Beqaj SH Han J | 2007 | Am J Clin Pathol2007，127，1： | 1 |
| 13 | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway显示文摘 | Park KS Lee RD Kang SK Han SY Park KL Yang KH | 2004 | Exp Cell Res2004，297，2： | 1 |
| 14 | Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia显示文摘 | Back SA Han BH Luo NL Chricton CA Tam J Arvin KL | 2002 | J Neurosci2002，22，2： | 1 |
| 15 | Hepatic hemangioma :contrast-enhcncemnt pattem during the arterial and portal venous phases or spiralCT显示文摘 | Yun Kl Choi BI Han JK | 1999 | Abdom Imaging1999，24，3： | 1 |
| 16 | Enhanced dermal wound neo- vascularization by targeted delivery of endothelial progenitor ceils u- sing an RGD-g-PLLA scaffold 显示文摘 | Kim KL Han DK Park K | 2009 | Biomaterials2009，30，22： | 1 |
| 17 | Climate change impacts on groundwater and dependent ecosystems显示文摘 | Bj?rn Kl?ve Pertti Ala-Aho Guillaume Bertrand Jason J. Gurdak Hans Kupfersberger Jens Kv?rner Timo Muotka Heikki Mykr? Elena Preda Pekka Rossi Cintia Bertacchi Uvo Elzie Velasco Manuel Pulido-Velázquez | 2013 | Journal of Hydrology2013，，： | 1 |
| 18 | Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia显示文摘 | Back SA Han BH Luo NL Chricton CA Xanthoudakis S Tam J Arvin KL Holtzman DM | 2002 | J Neurosci2002，22，2： | 1 |
| 19 | Minocycline markedly protects the neo- natal brain against hypoxic-ischcmic injury 显示文摘 | Arvin KL Han BH Du Y el al | 2002 | Ann Neurol2002，52，1： | 1 |
| 20 | Life-course predictors of ultrasonic heel measurement in a crosssectional study of immigrant women from Southeast Asia显示文摘 | Lauderdale DS Salant T Han KL | 2001 | Am J Epidemiol2001，153，6： | 1 |
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