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| 1 | A cysteine-selective fluorescent probe for the cellular detection of cysteine显示文摘 | Jung H S HanJ H Pradhan T | | 0，，03： | 1 |
| 2 | Leucyl-tRNA Synthetase Is an IntraceUular Leucine Sensor for the mTORCl-Signaling Path- way 显示文摘 | HANJ M JEONG S J PARK M C | 2012 | Cell2012，149，： | 1 |
| 3 | Electroacupuncture facilitates recovery of male sexual behavior in morphine withdrawal rats显示文摘 | Cui G H Ren X W Wu L Z HanJ S Cui C L | 2004 | Neurochen Res2004，29，： | 1 |
| 4 | Glyco alka- loids and me tabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells 显示文摘 | Lee K R Kozukue N HanJ S | 2004 | J Agric Food Chem2004，52，10： | 1 |
| 5 | Optical parameters of NaY(WO4)2 crystals doped with Pr and Ho显示文摘 | CHENG Z X ZHANG S J HANJ R | 2001 | Cryst Res Technol2001，36，45： | 1 |
| 6 | Levels of PCDD/Fs and DL-PCBs in selected foods and estimated dietary intake for the local residents of Luqiao and Yuhang in Zhejiang,China显示文摘 | Yang S Wu N X HanJ L | 2011 | Chemosphere2011，85，3： | 1 |
| 7 | Polychlorinated dibenzo-p-dioxins/furans and polyehlorinated biphenyls in human adipose tissue from Zhejiang Province, China 显示文摘 | Shen H T HanJ L Tie X W XuW Ren Y P Ye C S | 2009 | Chemosphere2009，74，3： | 1 |
| 8 | Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORCl-signaling pathway 显示文摘 | HANJ M JEONG S J PARK M C | 2012 | Cell2012，149，2： | 1 |
| 9 | Changes in isoflavone content andmass balance during soybean processing显示文摘 | HANJ S HONG H D KIM S R | 2007 | Food Sci Biotechnol2007，16，3： | 1 |
| 10 | 显示文摘 | ZhuJ HanJ Meng S | 2004 | Vacuum2004，72，3： | 1 |
| 11 | Biocompatibility and osteo conduction o{ active porous calcium - phosphate films on a novel Ti - 3Zr - 2Sn - 3Mo - 25Nb biomedical alloy 显示文摘 | Yu S Yu Z T HanJ Y | 2011 | Colloids and Surfaces B Biointerfaces2011，85，2： | 1 |
| 12 | Acupuncture and endorphins显示文摘 | HanJ S | 2004 | Neuroscilett2004，361，1： | 1 |
| 13 | Phosphate adsorption on aluminum-impregnated mesoporous silicates: Surface structure and behavior of adsorbents显示文摘 | SHIN E W HANJ S JANG M | 2004 | Environmental Science & Tech- nology2004，38，3： | 1 |
| 14 | Cidea is associated with lipid droplets and insulin sensitivity in humans显示文摘 | Puri V HanJ Jt S Konda S Nicoloro SM Straubbaa Chawla A | 2008 | P Nat! Acad Sci USA2008，105，22： | 1 |
| 15 | Improving Privacy and Security inDecentralized Ciphertext-Policy Attribute-Based Encryption显示文摘 | HANJ WU S MU Y | 2015 | IEEETransactions on Information Forensics and Security2015，10，03： | 1 |
| 16 | Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species显示文摘 | CHEN S L Y AO H HANJ P | 2010 | PLoS One2010，5，1： | 1 |
| 17 | Peri- operative measures for treatment and prevention of cerebral vaso- spasm following subaraehnoid hemorrhage 显示文摘 | Alaraj A Charbel FT Amin- Hanj ani S | 2009 | Neurol Res2009，31，6： | 1 |
| 18 | Cystic fibrosis patients on cystic fibrosis transmembrane conductance regulator modulators have a reduced incidence of cirrhosis显示文摘BACKGROUND Cystic fibrosis transmembrane conductance regulator(CFTR)modulators significantly improve pulmonary function in patients with cystic fibrosis(CF)but the effect on hepatobiliary outcomes remains unknown.We hypothesized that CF patients on CFTR modulators would have a decreased incidence of cirrhosis compared to patients not on CFTR modulators or on ursodiol.AIM To investigate the effect of CFTR modulators on the development of cirrhosis in patients with CF.METHODS A retrospective analysis was performed using Truven MarketScan from January 2012 through December 2017 including all patients with a diagnosis of CF.Patients were excluded if they underwent a liver transplantation or if they had other etiologies of liver disease including viral hepatitis or alcohol use.Subjects were grouped by use of CFTR modulators,ursodiol,dual therapy,or no therapy.The primary outcome was development of cirrhosis.Kaplan-Meier curves estimated the incidence of cirrhosis and log-rank tests compared incidence curves between treatment groups.RESULTS A total of 7201 patients were included,of which 955(12.6%)used a CFTR modulator,529(7.0%)used ursodiol,105(1.4%)used combination therapy,and 5612(74.3%)used neither therapy.The incidence of cirrhosis was 0.1%at 1 year and 0.7%at 4 years in untreated patients,5.9%and 10.1%in the Ursodiol group,and 1.0%and 1.0%in patients who received both therapies.No patient treated with CFTR modulators alone developed cirrhosis.Patients on CFTR modulators alone had lower cirrhosis incidence than untreated patients(P=0.05),patients on Ursodiol(P<0.001),and patients on dual therapy(P=0.003).The highest incidence of cirrhosis was found among patients treated with Ursodiol alone,compared to untreated patients(P<0.001)or patients on Ursodiol and CFTR modulators(P=0.01).CONCLUSION CFTR modulators are associated with a reduction in the incidence of cirrhosis compared to other therapies in patients with CF. | Mitchell L Ramsey Michael R Wellner Kyle Porter Stephen E Kirkby Susan S Li Luis F Lara Sean G Kelly A James Hanje Lindsay A Sobotka | 2022 | World Journal of Hepatology2022，14，2： | 0 |
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