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| 1 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 2 | Post-endoscopic retrograde cholangiopancreatography pancreatitis: Risk factors and predictors of severity显示文摘AIM To detect risk factors for post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) and investigate the predictors of its severity.METHODS This is a prospective cohort study of all patients who underwent ERCP.Pre-ERCP data,intraoperative data,and post-ERCP data were collected.RESULTS The study population consisted of 996 patients.Their mean age at presentation was 58.42(± 14.72) years,and there were 454 male and 442 female patients.Overall,PEP occurred in 102(10.2%) patients of the study population; eighty(78.4%) cases were of mild to moderate degree,while severe pancreatitis occurred in 22(21.6%) patients.No hospital mortality was reported for any of PEP patients during the study duration.Age less than 35 years(P = 0.001,OR = 0.035),narrower common bile duct(CBD) diameter(P = 0.0001) and increased number of pancreatic cannulations(P = 0.0001) were independent risk factors for the occurrence of PEP.CONCLUSION PEP is the most frequent and devastating complication after ERCP.Age less than 35 years,narrower median CBD diameter and increased number of pancreaticcannulations are independent risk factors for the occurrence of PEP.Patients with these risk factors are candidates for prophylactic and preventive measures against PEP. | Ayman El Nakeeb Ehab El Hanafy Tarek Salah Ehab Atef Hosam Hamed Ahmad M Sultan Emad Hamdy Mohamed Said Ahmed A El Geidie Tharwat Kandil Mohamed El Shobari Gamal El Ebidy | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 10 |
| 3 | Intraoperative endoscopic retrograde cholangiopancreatography: A useful tool in the hands of the hepatobiliary surgeon显示文摘AIM: To evaluate the efficacy of intraoperative endoscopic retrograde cholangio-pancreatography(ERCP) combined with laparoscopic cholecystectomy(LC) forpatients with gall bladder stones(GS) and common bile duct stones(CBDS).METHODS: Patients treated for GS with CBDS were included. LC and intraoperative transcystic cholangiogram(TCC) were performed in most of the cases. Intraoperative ERCP was done for cases with proven CBDS.RESULTS: Eighty patients who had GS with CBDS were included. LC was successful in all cases. Intraoperative TCC revealed passed CBD stones in 4 cases so intraoperative ERCP was performed only in 76 patients. Intraoperative ERCP showed dilated CBD with stones in 64 cases(84.2%) where removal of stones were successful; passed stones in 6 cases(7.9%); short lower end stricture with small stones present in two cases(2.6%) which were treated by removal of stones with stent insertion; long stricture lower 1/3 CBD in one case(1.3%) which was treated by open hepaticojejunostomy; and one case(1.3%) was proved to be ampullary carcinoma and whipple's operation was scheduled. CONCLUSION: The hepatobiliary surgeon should be trained on ERCP as the third hand to expand his field of therapeutic options. | Ayman El Nakeeb Ahmad M Sultan Emad Hamdy Ehab El Hanafy Ehab Atef Tarek Salah Ahmed A El Geidie Tharwat Kandil Mohamed El Shobari Gamal El Ebidy | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 4 | Seed germination and proline accumulation in Rice ( Oryza sativa L ) as affected by salt concentrations 显示文摘 | MOMAYEZI M R ZAHARAH A R HANAFI M M | 2009 | J Trop Agric Food Sci2009，32，2： | 1 |
| 5 | Indoleamine 3,4-dioxygenase expression in human cancers:clinical and immunologicperspectives显示文摘 | Godin-Efhier Hanafi L A Piccirillo C A | 2011 | Clin Cancer2011，17，22： | 1 |
| 6 | Ex- tension of quickest spectrum sensing to multiple an- tennas and rayleigh channels显示文摘 | HANAFI E MARTIN P A SMITH P J | 2013 | IEEE Communica- tions Letters2013，17，4： | 1 |
| 7 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug 显示文摘 | Hanafy A Spahn-Langguth H Vergnault G | 2007 | Adv Drug Deliv Rev2007，59，6： | 1 |
| 8 | Concentration effect of palm oil fatty acid on curing characteristics and mechanical properties of carbon black filled NR compounds 显示文摘 | Hanafi Ismail Ruhaizat T A | 1997 | International Journal Polymer Mater1997，，38： | 1 |
| 9 | Catalytic con-version of ethanol and isop ropanol over the Mn2 O3/AI9O3system doped with Na20 显示文摘 | Doheim M M Hanafy S A El-Shobaky G A | 2002 | Materials Letters2002，55，5： | 1 |
| 10 | Are long-term vegetation dynamics useful in monitoring and assessing desertification processes in the arid steppe, southern Tunisia显示文摘 | Hanafi A Jauffret S | 2008 | Journal of Arid Environments2008，72，4： | 1 |
| 11 | Are long-term vegetation dynamics useful in monitoring and assessing desertification processes in the arid steppe, southern Tunisia显示文摘 | Hanafi A Jauffret S | 2008 | Journal Arid Environments2008，72，： | 1 |
| 12 | Nanosuspension formulations for low-soluble drugs: pharmacokinetic evaluation using spironolactone as model compound 显示文摘 | Langguth P Hanafy A Frenzel D | 2005 | Drug Dev IndPharm2005，31，3： | 1 |
| 13 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug显示文摘 | Hanafy A Spahn-Langguth H Vergnault G | 2007 | Adv Drug Del Rev2007，59，2： | 1 |
| 14 | Surface properties of silica produced by thermal treatment of rice husk ash 显示文摘 | HANAFI S ABO-EL-ENEIN S A IBRAHIM D M | 1980 | ThermochimActa1980，37，： | 1 |
| 15 | Intestinal drug efflux:formulation and food effects 显示文摘 | Wagner D Spahn-Langguth H Hanafy A | 2001 | Adv Drug Deliv Rew2001，50，1： | 1 |
| 16 | Nanosuspension formulations for low-soluble drugs:pharmacokinetic evaluation using spironolactone as model compound显示文摘 | Langguth P Hanafy A Frenzel D | 2005 | Drug Dev Ind Pharm2005，31，3： | 1 |
| 17 | Intestinal drug efflux: formulation and food effects显示文摘 | WAGNER D SPAHN-LANGGUTH H HANAFY A | 2001 | Adr Drug Deliv Rew2001，50，1： | 1 |
| 18 | Character- ization and Catalytic Activities of ZrO2-TiO2 Supported Hy- drodesulfurization Catalysts显示文摘 | Hanafi S A E1-Syed H A Elmelawy M S | 2009 | PetSci Technol2009，27，1： | 1 |
| 19 | Phosphorus leaching in an acid tropical soil 'recapitalized' with phosphate rock and triple superphosphate显示文摘 | Gikonyo E Zaharah A R Hanafi M M | 2010 | The Scientific World Journal2010，10，： | 1 |
| 20 | Cerebral inflammatory response and predictors of admission clinical grade after aneurysmal subarachnoid hemorrhage显示文摘 | Khalid A Hanafy R Morgan Stuart | 2010 | Journal of Clinical Neuroscience2010，17，1： | 1 |
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