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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | A silicon nanocrystals based memory显示文摘 | Rana F Hanafi H | 1996 | Appl Phys Lett1996，68，10： | 1 |
| 3 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug 显示文摘 | Hanafy A Spahn-Langguth H Vergnault G | 2007 | Adv Drug Deliv Rev2007，59，6： | 1 |
| 4 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug显示文摘 | Hanafy A Spahn-Langguth H Vergnault G | 2007 | Adv Drug Del Rev2007，59，2： | 1 |
| 5 | Genetic algorithm with iterated lo- cal search for solving a location-routing problem显示文摘 | Derbel H Jarboui B Hanafi S | 2012 | Expert Systems with Applications2012，39，3： | 1 |
| 6 | Intestinal drug efflux:formulation and food effects 显示文摘 | Wagner D Spahn-Langguth H Hanafy A | 2001 | Adv Drug Deliv Rew2001，50，1： | 1 |
| 7 | Intestinal drug efflux: formulation and food effects显示文摘 | WAGNER D SPAHN-LANGGUTH H HANAFY A | 2001 | Adr Drug Deliv Rew2001，50，1： | 1 |
| 8 | Character- ization and Catalytic Activities of ZrO2-TiO2 Supported Hy- drodesulfurization Catalysts显示文摘 | Hanafi S A E1-Syed H A Elmelawy M S | 2009 | PetSci Technol2009，27，1： | 1 |
| 9 | Assessment of synthetic zeolite Na A-X as sorbing barrier for strontium in a radioactive disposal facility显示文摘 | ABDEL RAHMAN R O LBRAHIM H A HANAFY M | 2010 | Chemical Engineering Journal2010，157，： | 1 |
| 10 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug 显示文摘 | HANAFY A SPAHN-LANGGUTH H VERGNAULT G | 2007 | Advanced Drug Delivery Reviews2007，59，6： | 1 |
| 11 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug显示文摘 | HANAFY A SPAHN-LANGGUTH H VERGNAULT G | 2007 | Adv Drug Delivery Rev2007，59，6： | 1 |
| 12 | Maturation, fecundity and seasonality of reproduction of two commercially valuable cuttlefish, Sepia pharaonis and S. dollfusi , in the Suez Canal显示文摘 | Howaida R Gabr Roger T Hanlon Mahmoud H Hanafy Salah G El-Etreby | 1998 | Fisheries Research1998，，2： | 1 |
| 13 | Inteslinal drug effluxformulation and food effects显示文摘 | WAGNER D SPAHN-LANGGNTH H HANAFY A | 2001 | Adv Drug Deliv Rev2001，50，1： | 1 |
| 14 | A silicon nanocrystals based memory 显示文摘 | TIWARI S RANA F HANAFI H | 1996 | Applied Physics Letters1996，68，10： | 1 |
| 15 | Thermo mechanical performance of natural rubber/recycled ethylene propylene-diene rubber blends in the presence of ZnO nanopartiele显示文摘 | NABIL H HANAFI I | 2015 | International Journal of Polymer Analysis and Characterization2015，20，6： | 1 |
| 16 | Preliminary Evidence of Effects of Crisis Intervention Team Training on Self-Efficacy and Social Distance 显示文摘 | Bohara M Hanafi S Chien V H | 2008 | Adm Policy Ment Health2008，35，： | 1 |
| 17 | Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug显示文摘 | Hanafy A SpahnLangguth H Vergnault G | 2007 | Adv Drug Delivery Rev2007，59，6： | 1 |
| 18 | A silicon nanocrystals based memory 显示文摘 | TIWARI S RANA F HANAFI H | 1996 | APL1996，68，： | 1 |
| 19 | Intestinal drugefflux:formulation and food effects显示文摘 | Wagner D Spahn-Langguth H Hanafy A | 2001 | Adv Drug Deliv Rev2001，50，1： | 1 |
| 20 | 显示文摘 | Hanafy M Nabin H J | 2007 | Energy Sources Part A:Recovery Utilization and Environmental Effects2007，29，2： | 1 |
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