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| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Phytotherapy in diabetes: Review on potential mechanistic perspectives显示文摘Diabetes mellitus(DM) is a widely spread epidemic dis ease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multi factorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Tradition ally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the differen literature resources and various database and in view o the above aspects, the present article provides a com prehensive review on the available antidiabetic plants that have been approved by pharmacological and clini cal evaluations, and which their mechanism(s) of ac tion is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from in testine, increasing insulin secretion from the pancreasinhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying. | Hanan S El-Abhar Mona F Schaalan | 2014 | World Journal of Diabetes2014，5，2： | 8 |
| 3 | Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats显示文摘Objective The aim of our study was to assess the complications of hepatic fibrosis associated with bile duct ligation and the potential curative role of sepia ink extract in hepatic damage induced by bile duct ligation. Methods Rattus norvegicus rats were divided into 3 groups: Sham-operated group, model rats that underwent common bile duct ligation(BDL), and BDL rats treated orally with sepia ink extract(200 mg/kg body weight) for 7, 14, and 28 d after BDL. Results There was a significant reduction in hepatic enzymes, ALP, GGT, bilirubin levels, and oxidative stress in the BDL group after treatment with sepia ink extract. Collagen deposition reduced after sepia ink extract treatment as compared to BDL groups, suggesting that the liver was repaired. Histopathological examination of liver treated with sepia ink extract showed moderate degeneration in the hepatic architecture and mild degeneration in hepatocytes as compared to BDL groups. Conclusion Sepia ink extract provides a curative effect and an antioxidant capacity on BDL rats and could ameliorate the complications of liver cholestasis. | Hanan Saleh Amel M Soliman Ayman S Mohamed Mohamed-Assem S Marie | 2015 | Biomedical and Environmental Sciences2015，28，8： | 6 |
| 4 | Diabetic macular edema:New promising therapies显示文摘The treatment of diabetic macular edema is rapidly evolving.The era of laser therapy is being quickly replaced by an era of pharmacotherapy.Several pharmacotherapies have been recently developed for the treatment of retinal vascular diseases such as diabetic macular edema.Several intravitreal injections or sustained delivery devices have undergone phase 3 testing while others are currently being evaluated.The results of clinical trials have shown the superiority of some of these agents to laser therapy.However,with the availability of several of these newer agents,it may be difficult to individualize treatment options especially those patients respond differently to various therapies.As such,more effort is still needed in order to determine the best treatment regimen for a given patient.In this article,we briefly summarize the major new therapeutic additions for the treatment of diabetic macular edema and allude to some future promising therapies. | Hanan N Al Shamsi Jluwi S Masaud Nicola G Ghazi | 2013 | World Journal of Diabetes2013，4，6： | 4 |
| 5 | Anti-inflammatory activity of the glandular extracts of Thunnus alalunga显示文摘Objective:To evaluate the anti-inflamattory activity of Thunnus alalunga by both in vitro and in vivo methods.Methods:Anti-inflammatory activity of the chloroform water extract of Thunnus alalunga was done by both in vitro and in vivo methods.In vitro method was done by human red blood cells membrane stabilization method(HRBC).In vivo evaluation was estimated on Wister albino rats.Acute toxicity studies were done on the extract and no toxicity was reported.Results: The percentage protection exhibited by 300 mg/mL concentration was more when compared to the other ones.The 400 mg/mL concentration showed potent activity on comparison with the standard during in vivo evaluation.Conclusions:In both means of estimation the extract of Thunnus alalunga was found to possess significant anti-inflammatory activity. | A.K.Azeem C Dilip S S Prasanth V Junise Hanan Shahima Kumsr Sajeev C.Naseera | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 3 |
| 6 | Rice Morphogenesis and Plant Architecture : Measurement, Specification and the Reconstruction of Structural Development by 3D Architectural Modelling 显示文摘 | Tomonari Watanabe Jim S Hanan Peter M Room | 2005 | Annals of Botany2005，，95： | 1 |
| 7 | Linking physiological and architectural models of cotton 显示文摘 | Hanan J S Hearn A B | 2003 | Agricultural Systems2003，75，： | 1 |
| 8 | Experience with SAND-TCL:A scripting tool for spatial databases显示文摘 | Claudio E Hanan S | 2002 | Journal of Visual Languages & Computing2002，13，2： | 1 |
| 9 | Index-driven similarity search in metric spaces显示文摘 | Gisli R Hjaltason Hanan S | 2003 | ACM Transactions on Database Systems2003，28，4： | 1 |
| 10 | Linking physiological and architectural models of cotton 显示文摘 | Hanan J S Hearn A B | 2003 | Agricultural Systems2003，75，： | 1 |
| 11 | On voting-based consensus of cluster en- sembles显示文摘 | Hanan G A Mohamed S K | 2010 | Pattern Recognition2010，43，5： | 1 |
| 12 | Adsorption/desorption of Cd(11),Cu(11) and Pb (11) using chemically modifedorange peel:Equilibrium and kinetic studies显示文摘 | Mohamed R L Nabila S A Hanan S I | 2012 | Solid State Sciences2012，14，2： | 1 |
| 13 | Chemoprerention of aominduced colon eareinogesis by dietary curcumin , a natural acecring plant phenolic compound 显示文摘 | HANAN S ARDECT K MITTLE A | 1997 | Cancer Res1997，57，4： | 1 |
| 14 | An outbreak of Japanese encephalitis in the Torres Strait Anstralia显示文摘 | Hanan J N Ritchie S A Phillips D A | 1996 | Med J Anst1996，165，5： | 1 |
| 15 | On SIP Session Setup Delay for VolP Services Over Correlated Fading Channels 显示文摘 | Hanane Fathi Shyam S Chakraborty Ramjee Prasad | | Vehicular Technology IEEE Transactions on Volume: 55 Issue: 10，，： | 1 |
| 16 | Estimation of absorbed photosynthetically active radiation and vegetation net production efficiency using satellite data显示文摘 | Hanan N P Prince S D A Begue | 1995 | Agricultural and Forest Meteorology1995，76，： | 1 |
| 17 | Comparison of crop model validation methods 显示文摘 | CAO H X HANAN J S LIU Y | 2012 | Journal of Integrative Agriculture (Formerly Agricultural Sciences in China)2012，11，8： | 1 |
| 18 | The value of troponin-I measurement in assessment of an thracycline induced cardiotoxicity among breast cancer patients显示文摘 | Lobna S Emad H Hanan S | 2000 | Cancer Inst2000，12，1： | 1 |
| 19 | Evolving treatment strategies for inflammatory bowel disease显示文摘 | Hananer S Dassopoulos T | 2001 | Annu Rev Med2001，52，： | 1 |
| 20 | Optimization of SIP Session Setup Delay for VolP in 3G Wireless Networks显示文摘 | Hanane Fathi Shyam S Chakraborty Ramjee Prasad | 2006 | IEEE Trans Mobile Computing2006，5，9： | 1 |
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