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| 1 | An old emperor finds new clothing: rejuvenation in our time显示文摘 | David J Handelsman | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 2 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 3 | Falling sperm counts and global oestrogenic pollution:postscript显示文摘 | Trevor G Cooper David J Handelsman | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 4 | Molecular biological access to the chemistry of unknown soil microbes:a new frontier for natural products显示文摘 | Handelsman J Rondon M R Brady S P | 1998 | Chem Biol1998，5，10： | 1 |
| 5 | Does combination anti- microbial therapy reduce mortality in Gram-negative bacterae- mia? A meta-analysis显示文摘 | Safdar N Handelsman J Maki DG | 2004 | Lancet Infect Dis2004，4，8： | 1 |
| 6 | Molecular biolo- gical access to the chemistry of unknown soil microbes: a new frontier for natural products显示文摘 | Handelsman J Rondon MR Brady SF | 1998 | Chemistry Biology1998，5，10： | 1 |
| 7 | Biocontrol of soilborne plant pathoens显示文摘 | Handelsman J Stabb E V | 1996 | The Plant Cell1996，8，： | 1 |
| 8 | Molecular biological access to the chemistry of unknown soil microbes : a new frontier for natural products 显示文摘 | Handelsman J Rondon MR Brady SF | 1998 | Chem Biol1998，5，10： | 1 |
| 9 | Biocontrol of plant disease:a (Gram-) positive perspective显示文摘 | Elizabeth A B E Handelsman J O | 1999 | FEMS Microbiology Letters1999，171，： | 1 |
| 10 | Hormonal therapy of cryptorchidism: A randomized, double - blind study comparing human chorionic gonadotropin and gonadotropin - releasing hormone显示文摘 | Rajfer J Handelsman DJ Swerdloff RS | 1986 | N Engl J Med1986，314，8： | 1 |
| 11 | Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA显示文摘 | Brady S F Chao C J Handelsman J | 2001 | Org Lett2001，3，13： | 1 |
| 12 | Molecular biological access to the chemistry of unknown soil microbes : a new frontier for natural products显示文摘 | Handelsman J Rondon M R Brady S F | 1998 | Chemical Biology1998，5，10： | 1 |
| 13 | Metagenomics: application of genomics to uncultured microorganisms显示文摘 | Handelsman J | 2004 | Microbiology and Molecular Biology Reviews2004，68，4： | 1 |
| 14 | Molecular biological access to the chemistry of unknown soil microbes : a new frontier for natural products显示文摘 | Handelsman J Rondon M R Brady S F | 1998 | Chem Biol1998，5，： | 1 |
| 15 | Molecular bio-logical access to the chemistry of unknown soil microbes:A new frontier for natural products显示文摘 | Handelsman J Rondon M R Brady S F | 1998 | Chem Biol1998，5，10： | 1 |
| 16 | Biocontrol of soil- borne plant pathogens显示文摘 | Stabb E V | 1996 | The plant cell1996，8，： | 1 |
| 17 | Molecularbiological access to the chemistry of unkown soil microbes:a newfrontier for natural products显示文摘 | HANDELSMAN J RONDON M R BRADY S F | 1998 | Chemistry&Biology1998，5，10： | 1 |
| 18 | The rela-tionship between 3', 5' -cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells显示文摘 | Gorczynska E Spaliviero J Handelsman DJ | 1994 | Endocrinology1994，134，11： | 1 |
| 19 | Biocontrol of soilborne plant pathogens显示文摘 | HANDELSMAN J STABB E | 1996 | Plant Cell1996，8，： | 1 |
| 20 | Neuroendocrine dysfunction in sleep apnoea: reversal by continuous positive airways pressure therapy 显示文摘 | Gnmstein R R Handelsman D J Lawrence S J | 1989 | J Clin Endocrinol Metab1989，68，2： | 1 |
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