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| 1 | Pharmacokinetics of enteric-coated mycophenolate sodium in Chinese renal transplantation recipients显示文摘 | QIU Kui TIAN Hui WANG Wei HU Xiao-peng LI Xiao-bei GONG Li-li LUO Wei LIU Li-hong ZHANG Xiao-dong YIN Hang | 2012 | Chinese Medical Journal2012，，23： | 8 |
| 2 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 3 | Zircon U-Pb Geochronology and Geochemical Characteristics of the Volcanic Host Rocks from the Tongyu VHMS Copper Deposit in the Western North Qinling Orogen and Their Geological Significance显示文摘Precise in situ zircon U-Pb dating and Lu–Hf isotopic measurement using an LA-ICP-MS system, whole-rock major and trace element geochemistry and Sr–Nd isotope geochemistry were conducted on the volcanic host rocks of the Tongyu copper deposit on the basis of further understanding of its geological characteristics. Three zircon samples from the volcanic host rocks yielded 206Pb/238 U weighted average ages ranging from 436±4 Ma to 440±5 Ma, which are statistically indistinguishable and coeval with the ca. 440 Ma northward subduction event of the Paleo-Qinling oceanic slab. The volcanic host rocks were products of magmatic differentiation that evolved from basalt to andesite to dacite to rhyolite, forming an integrated tholeiitic island arc volcanic rock suite. The primitive mantle-normalized trace element patterns for most samples show characteristics of island arc volcanic rocks, such as relative enrichment of LILE(e.g. Th, U, Pb and La) and depletion of HFSE(e.g. Nb, Ta, Ti, Zr and Hf). Discrimination diagrams of Ta/Yb vs Th/Yb, Ta vs Th, Yb vs Th/Ta, Ta/Hf vs Th/Hf, Hf/3 vs Th vs Nb/16, La vs La/Nb and Nb vs Nb/Th all suggest that both the volcanic host rocks from the Tongyu copper deposit and the volcanic rocks from the regional Xieyuguan Group were formed in an island arc environment related to subduction of an oceanic slab. Values of ISr(0.703457 to 0.708218) and εNd(t)(-2 to 5.8) indicate that the source materials of volcanic rocks from the Tongyu copper deposit and the Xieyuguan Group originated from the metasomatised mantle wedge with possible crustal material assimilation. Most of the volcanic rock samples show good agreement with the values of typical island arc volcanic rocks in the ISr-εNd(t) diagram. The involvement of crustal-derived material in the magma of the volcanic rocks from the Tongyu copper deposit was also reflected in the zircon εHf(t) values, which range from-3.08 to 10.7, and the existence of inherited ancient xenocrystic zircon cores(2616±39 Ma and 1297±22 Ma). The mineralization of the Tongyu copper deposit shows syn-volcanic characteristics such as layered orebodies interbedded with the volcanic rock strata, thus, the zircon U-Pb age of the volcanic host rocks can approximately represent the mineralization age of the Tongyu copper deposit. Both the Meigou pluton and the volcanic host rocks were formed during the ca. 440 Ma northward subduction of the Paleo-Qinling Ocean when high oxygen fugacity aqueous hydrothermal fluid released by dehydration of the slab and the overlying sediments fluxed into the mantle wedge, triggered partial melting of the mantle wedge, and activated and extracted Cu and other ore-forming elements. The magma and ore-bearing fluid upwelled and erupted, and consequently formed the island arc volcanic rock suite and the Tongyu VHMS-type copper deposit. | XIONG Xiao ZHU Laimin LI Ben ZHANG Guowei GONG Hujun ZHENG Jun JIANG Hang | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 4 | Improved two-way satellite time and frequency transfer with Multi-GEO in BeiDou navigation system显示文摘Due to the limitation of Geostationary Earth Orbit(GEO)satellite resources,only very few TWSTFT links with parallel counterpart operating via diferent GEO satellites between two ground stations are available.There are 5 GEO satellites in BeiDou Navigation System,which enables an improved TWSTFT with Multi-GEO.Two algorithms are put forward to take the advantage of Multi-GEO links to improve the performance of time and frequency transfer respectively.The dynamic weight average algorithm based on a newly proposed dynamic time variance aiming at improving the performance of time transfer is shown to be able to reduce the dynamic time deviation of the two-way measurement result to 1/√N dynamic time deviation of the single link using N-GEO links,if each link has similar level of link noises.The algorithm of cancelling out the link noise Allan variances with 2-GEO links is expected to obtain the Allan variance of clock diference between two ground stations.The experiment results using 2-GEO links in BeiDou Navigation System show that the dynamic weight average algorithm can improve the dynamic time deviation of the two-way measurement to around 0.6 of that of the single link in an average concept.And the estimated Allan deviation of the clock diference using the algorithm for cancelling the noise Allan variances of both links can reach 7×10 12(τ0.65)for the averaging time 1–105s which is within the same order of magnitude as the estimated Allan deviation based on carrier Doppler measurement for the averaging time 10 s–104s,despite the noisy links with the Allan deviation follows 3×10 10(τ1). | YANG WenKe GONG Hang LIU ZengJun LI YuanLing SUN GuangFu | 2014 | Science China(Information Sciences)2014，57，2： | 4 |
| 5 | Function of male and hermaphroditic flowers and size-dependent gender diphasy of Lloydia oxycarpa (Liliaceae) from Hengduan Mountains显示文摘Although hermaphroditism is common in flowering plants, unisexual flowers occur in many plant taxa,forming various sexual systems. However, the sexual system of some plants is difficult to determine morphologically, given that their sex expression may be influenced by both genetic and environmental factors. Specifically, androdioecy(the coexistence of both male and hermaphroditic individuals in the same population) has often been confused with the gender diphasy, a gender strategy in which plants change their sex expression between seasons. We studied the reproductive function of male and hermaphroditic flowers of Lloydia oxycarpa(Liliaceae), in order to investigate its sexual system and determine whether it is a gender-diphasic species. We found that although male flowers occur in a considerable number of plants, relative to hermaphrodites, they did not exhibit any significant reproductive advantage in terms of flower size, pollen quantity, attractiveness to visitors or siring success. In addition, this plant has spontaneous self-pollination and showed no inbreeding depression. These results render the maintenance of male individuals almost impossible. Furthermore, a considerable number of individuals changed their sex in successive years. The sex expression was found to be related to bulb size and dry weight, with larger individuals producing hermaphroditic flowers and smaller individuals producing male flowers. These results suggest that L. oxycarpa is not an androdioecious plant but represents a rare case of size-dependent gender diphasy. | Yang Niu Qiangbang Gong Deli Peng Hang Sun Zhimin Li | 2017 | Plant Diversity2017，39，4： | 3 |
| 6 | 控制气管插管套囊压力与术后并发症关系的多中心研究显示文摘背景与气管插管相关的术后呼吸系统并发症通常表现为咳嗽、咽喉痛、声嘶、痰中带血。该研究中,我们研究了短时间(数小时)测量和控制气管插管套囊(endotracheal tube cuff,ETrc)压力对术后并发症的影响。方法选择中国上海4所大学附属三级医院拟在全身麻醉下行择期手术的患者509例,分为不测量ETTc压力的对照组和测量并调整ETTc压力的研究组,记录手术时间和插管时间。每组选择插管时间在120—180分钟的20例患者,拔管后即刻行纤维支气管镜检查。拔管后24小时记录咳嗽、咽喉痛、声嘶、痰中带血等气管插管相关并发症。结果两组间性别、年龄、身高、体重、手术时间和插管时问均无显著性差异。研究组调整前通过触摸指示气囊估计的平均ETTc压力为43±23.3mmHg(最高210mmHg),调整后为20±3.1mmHg(P〈0.001)。对照组术后咽喉痛、声嘶、痰中带血的发生率明显高于研究组。随着插管时间的增加,对照组中咽喉痛和痰中带血的发生率增加。研究组中咽喉痛的发生率也随插管时间增加而增加。对40例患者的纤维支气管镜检查结果显示支气管黏膜均有不同程度的损伤,对照组的损伤比研究组更严重。结论依据个人经验通过触捏估计ETTc压力明显高于测量结果或最适压力。即使在短时间(1—3小时)手术中,通过压力计合理控制ETTc压也有助于减少E]丌相关的咳嗽、咽喉痛、声嘶、痰中带血等术后呼吸系统并发症。 | Jianhui Liu Xiaoqing Zhang Wei Gong Shitong Li Fen Wang Shukun Fu Mazhong Zhang Yannan Hang 安博(译) 杜金(校) | 2013 | 麻醉与镇痛2013，，1： | 3 |
| 7 | Synthesis and Antioxidant Properties of Novel Silybin Analogues显示文摘八新奇 silybin 类似物(7a-h ) 被综合并且他们包括清除的能力的抗氧化剂性质 DPPH 自由基上的超级氧化物阴离子自由基和禁止的效果被决定。几合成混合物显示出可比较的抗氧化的效果到橡黄素的。 | Jing Xu GONG Lin Jia WENG Feng WANG Yu Bin FENG Chang Xin ZHOU Hai Bo LI Yi Hang WU Xiao Jiang HAO Xiu Mei WU Hua BAI Joachim STOECKIGT Yu ZHAO | 2006 | Chinese Chemical Letters2006，17，4： | 2 |
| 8 | Galactosylation of rhamnogalacturonan-Ⅱ for cell wall pectin biosynthesis is critical for root apoplastic iron reallocation in Arabidopsis显示文摘Apoplastic iron(Fe)in roots represents an essential Fe storage pool.Reallocation of apoplastic Fe is of great importance to plants experiencing Fe deprivation,but how this reallocation process is regulated remains elusive,likely because of the highly complex cell wall structure and the limited knowledge about cell wall biosynthesis and modulation.Here,we present genetic and biochemical evidence to demonstrate that the Cdi-mediated galactosylation of rhamnogalacturonan-II(RG-II)is required for apoplastic Fe reallocation.Cdi is expressed in roots and up-regulated in response to Fe deficiency.It encodes a putative glycosyltransferase localized to the Golgi apparatus.Biochemical and mass spectrometry assays showed that Cdi catalyzes the transfer of GDP-L-galactose to the terminus of side chain A on RG-II.Disruption of Cdi essentially decreased RG-II dimerization and hence disrupted cell wall formation,as well as the reallocation of apoplastic Fe from roots to shoots.Further transcriptomic,Fourier transform infrared spectroscopy,and Fe desorption kinetic analyses coincidently suggested that Cdi mediates apoplastic Fe reallocation through extensive modulation of cell wall components and consequently the Fe adsorption capacity of the cell wall.Our study provides direct evidence demonstrating a link between cell wall biosynthesis and apoplastic Fe reallocation,thus indicating that the structure of the cell wall is important for efficient usage of the cell wall Fe pool. | Jia-Shi Peng Bao-Cai Zhang Hao Chen Meng-Qi Wang Ya-Ting Wang Hong-Mei Li Shao-Xue Cao Hong-Ying Yi Hang Wang Yi-Hua Zhou Ji-Ming Gong | 2021 | Molecular Plant2021，14，10： | 2 |
| 9 | Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties显示文摘Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups(1-12) were designed and synthesized.The antioxidative properties of these compounds were evaluated.The modified silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin,with exception of the trimethoxylated ester(5) and the aliphatic one(9).Compounds 3,5,7,8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner. | Ke Xin Huang Jing Xu Gong Wei Xiong Lei Xiang Yang Feng Wang Qiao Feng Tao Yi Hang Wu Xiao Kun Li Joachim Stockigt Yu Zhao Jia Qu | 2009 | Chinese Chemical Letters2009，20，9： | 2 |
| 10 | Synthesis, Characterization, Polymerization of Optically Active Terminal Epoxides and Episulfides Bearing Bulky Groups显示文摘 | SUN Yun-kai ZHANG Jin LIU Hui-jun HE Li GONG Hang YANG Nian-fa | 2013 | Chemical Research in Chinese Universities2013，29，2： | 1 |
| 11 | Information theory applied to chromatographic fingerprint of herbal medicine for quality con- trol显示文摘 | GONG F HANG Y Z XIE P S | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 12 | Endovascular stent-graft treatment for aortoesophageal fistula induced by an esophageal fishbone:Two cases report显示文摘BACKGROUND Aortoesophageal fistula(AEF)induced by esophageal fishbones is a rare complication of esophageal foreign bodies and is very difficult to treat.Although the current view suggests that endovascular stent-graft treatment is useful for AEF,whether a subsequent thoracic operation is necessary remains controversial.The purpose of this report is to describe our experience using endovascular stentgraft treatment without combined thoracic operations for the treatment of AEF in two specific cases.CASE SUMMARY We presented two cases of patients complaining of retrosternal discomfort treated in our department for an aortoesophageal fistula caused by the accidental ingestion of a fishbone.The two patients were effectively managed with combined means of endoscopic,medical(broad-spectrum antibiotic therapy,fasting,gastrointestinal decompression,etc.)and endovascular stent-graft treatment.The main difference in treatment was that the first patient presented with hematemesis after endoscopic removal of the fishbone.Subsequently,the patient underwent endovascular stent-graft treatment.The second case was managed with endoscopic removal of the fishbone with simultaneous endovascular stent-graft treatment,without any signs of hematemesis or melena.Both patients had successful postoperative management and were discharged home.Long-term follow-up is ongoing.CONCLUSION The treatment decision-making process should depend on the patients’specific situations.Our practice indicates that endovascular stent-graft treatment without combined thoracic operations could be a valuable alternative in selected patients. | Hang Gong Wei Wei Zhong Huang Ying Hu Xian-Li Liu Zhen Hu | 2022 | World Journal of Clinical Cases2022，10，7： | 1 |
| 13 | Morbidity and risk factors for surgical site infection following cesarean section in Guangdong Province, China 显示文摘 | GONG Shi - peng GUO Hong - xia ZHOU Hang - zhen | 2012 | The Journal of Obstetrics and Gynecology Research2012，38，3： | 1 |
| 14 | Determination of Lightstruck Character in Beer by Gas Orromatography- Mass Spectroscopy显示文摘 | Gong F Hang Y Z Xie P S | 2003 | Journal of Chromatography2003，1002，： | 1 |
| 15 | Crystal structures of human IPP isomer- ase: new insights into the catalytic mechanism 显示文摘 | Cheng Zhang Lin Liu Hang Xu Zhiyi Weil Yanli Wang Ya- jing Lin Weimin Gong | 2007 | Journal of Molecular Biology2007，366，： | 1 |
| 16 | Direetly search- ing method for slip plane and its influential factors based on critical state of slope 显示文摘 | Lin Hang Cao Ping Gong Fengqiang | 2009 | Journal of Central South University of Technology2009，16，： | 1 |
| 17 | Malware Detection in Smartphones Using Static Detection and Evaluation Model Based on Analytic Hierarchy Process显示文摘Mobile malware is rapidly increasing and its detection has become a critical issue.In this study,we summarize the common characteristics of this malicious software on Android platform.We design a detection engine consisting of six parts:decompile,grammar parsing,control flow and data flow analysis,safety analysis,and comprehensive evaluation.In the comprehensive evaluation,we obtain a weight vector of 29 evaluation indexes using the analytic hierarchy process.During this process,the detection engine exports a list of suspicious API.On the basis of this list,the evaluation part of the engine performs a comprehensive evaluation of the hazard assessment of software sample.Finally,hazard classification is given for the software.The false positive rate of our approach for detecting malware samples is 4.7% and normal samples is 7.6%.The experimental results show that the accuracy rate of our approach is almost similar to the method based on virus signatures.Compared with the method based on virus signatures,our approach performs well in detecting unknown malware.This approach is promising for the application of malware detection. | Zhang Miao Yang Youxiu Cheng Gong Dong Hang Li Chengze | 2012 | China Communications2012，9，12： | 1 |
| 18 | Dual-buck half-bridge voltage balancer 显示文摘 | hang X Gong C | 2013 | IEEE Transactions on Industrial Electronics2013，60，8： | 1 |
| 19 | Plasma endothelin level changes during hemorrhagic shock显示文摘 | Hang C Gong JW Shih MW | 1993 | J Trauma1993，35，6： | 1 |
| 20 | Money, social status, and capital accumulation in a cash in advance model 显示文摘 | Liutang Gong and Hang fu Zou | 2001 | Journal of Money Credit and Banking2001，，33： | 1 |
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