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您的检索式：作者名="Yichen Gong"
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| 1 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 2 | Effect of SiO_(2) nano film deposited on copper and aluminium electrodes on the power frequency breakdown voltage of SF_(6) gas显示文摘In order to reveal the effect of insulating nano film on the insulation strength of SF_(6) gas gap,SiO_(2) nano film was deposited on the electrode surface by the plasma-enhanced chemical vapour deposition technique.The power frequency breakdown characteristics of SF_(6) gas under Cu and Al electrodes were obtained before and after coating.The results showed that when the Cu electrode was coated,the breakdown voltage was up to at most 11.5% higher than that of an uncoated Cu electrode in the pressure range of 0.2-0.5 MPa.When the Al electrode was coated,the breakdown voltage of SF_(6) gas was lower than that of an uncoated one in the pressure range of 0.2-0.5 MPa.The breakdown voltage of SF_(6) gas under the Cu electrode was slightly lower than that under the Al electrode,but the breakdown voltages under the coated Cu electrode were significantly higher than that under the coated Al electrode.Through SEM tests,it was found that the surface roughness of the electrode decreases after coating,but particles were formed on the surface of the Al electrode.The content of metal fluoride formed on the coated Al electrode under multiple breakdowns was significantly higher than that on the coated Cu electrode.The research results could provide references for improving insulation performance of GIS equipment. | Yu Zheng Shengle Gong Lei Liu Zhihui Xiang Yichen Lv Jianhui Yu Wenjun Zhou | 2023 | High Voltage2023，8，4： | 0 |
| 3 | Distribution Pattern of Urban Housing Price Based on Multiple Big Data:A Case Study of Beijing,Shanghai,Guangzhou,and Wuhan显示文摘The housing price has been paid close attention by people in all walks of life,and the development of big data provides a new data environment for the study of urban housing price.Housing price data of four national central cities (Beijing,Shanghai,Guangzhou and Wuhan) are taken as research samples.With the help of software GIS,exploratory spatial data analysis method is used to depict the spatial distribution pattern of urban housing price,and commonness and difference of spatial distribution of housing price are explored.The conclusions are as below:①regional imbalance of housing price in national central cities is significant.②Spatial distribution of urban housing price in Beijing,Shanghai,Guangzhou and Wuhan presents a polycentric pattern,and there is obvious spatial agglomeration.③The internal change of housing price in different cities has significant spatial difference.Beijing,Shanghai,Guangzhou and Wuhan are taken as typical city samples for research,with reference and practical significance,which could help to effectively predict spatial development trend of housing prices in other first and second tier cities.The research aims to provide certain reference for the government implementing real estate control policies according to local conditions,project location and reasonable pricing of real estate developers. | LIN Yichen WANG Li LIU Yating GONG Yue XU Jingyi | 2021 | Journal of Landscape Research2021，13，4： | 0 |
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