|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 2 | Microrheological Insights into the Dynamics of Amyloplasts in Root Gravity-Sensing Cells显示文摘在察觉到严肃的房间的 Amyloplast 沉积的 Biomechanical 分析。 | Zhongyu Zheng Junjie Zou Hanhai Li Shan Xue Yuren Wang Jie Le | 2015 | Molecular Plant2015，8，4： | 1 |
| 3 | Dynamical cavitation and oscillation of an anisotropic incompressible hyper-elastic sphere显示文摘Dynamical cavitation and oscillation of an anisotropic two-family fiber-reinforced incompressible hyper-elastic sphere subjected to a suddenly applied constant boundary dead load are examined within the framework of finite elasto-dynamics.An exact differential equation between the radius of the cavity and the applied load is obtained.The curves for the variation of the maximum radius of the cavity with the load and the phase diagrams are obtained by vibration theories and numerical computation.It is shown that there exists a critical value for the applied load.When the applied load is larger than the critical value,a spherical cavity will suddenly form at the center of the sphere.It is proved that the evolution of the cavity radius with time follows that of nonlinear periodic oscillation,and oscillation of the anisotropic sphere is not the same as that of the isotropic sphere. | REN JiuSheng LI HanHai YUAN XueGang CHENG ChangJun | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 0 |
| 4 | COUPLING EFFECTS OF VOID SHAPE AND VOID SIZE ON THE GROWTH OF AN ELLIPTIC VOID IN A FIBER-REINFORCED HYPER-ELASTIC THIN PLATE显示文摘The growth of a prolate or oblate elliptic micro-void in a fiber reinforced anisotropic incompressible hyper-elastic rectangular thin plate subjected to uniaxial extensions is studied within the framework of finite elasticity. Coupling effects of void shape and void size on the growth of the void are paid special attention to. The deformation function of the plate with an isolated elliptic void is given, which is expressed by two parameters to solve the differential equation. The solution is approximately obtained from the minimum potential energy principle. Deformation curves for the void with a wide range of void aspect ratios and the stress distributions on the surface of the void have been obtained by numerical computation. The growth behavior of the void and the characteristics of stress distributions on the surface of the void are captured. The combined effects of void size and void shape on the growth of the void in the thin plate are discussed. The maximum stresses for the void with different sizes and different void aspect ratios are compared. | Jiusheng Ren Hanhai Li Changjun Cheng Xuegang Yuan | 2012 | Acta Mechanica Solida Sinica2012，25，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员