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| 1 | Effects of interventions on oxidative stress and inflammation of cardiovascular diseases显示文摘Excessive oxidative stress and low-grade chronic inflammation are major pathophysiological factors contributing to the development of cardiovascular diseases (CVD) such as hypertension, diabetes and atherosclerosis. Accumulating evidence suggests that a compromised antioxidant system can lead to excessive oxidative stress in cardiovascular related organs, resulting in cell damage and death. In addition, increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis factor α, interleukin-6 and C-reactive protein, are closely related to morbidity and mortality of cardiovascular complications. Emerging evidence suggests that interventions including nutrition, pharmacology and exercise may activate expression of cellular anti-oxidant systems via the nuclear factor erythroid 2-related factor 2-Kelchlike ECH-associated protein 1 signaling pathway and play a role in preventing inflammatory processes in CVD. The focus of the present review is to summarize recent evidence showing the role of these anti-oxidant and anti-inflammatory interventions in cardiovascular disease. We believe that these findings may prompt new effective pathogenesis-oriented interventions, based on the exercise-induced protection from disease in the cardiovascular system, aimed at targeting oxidant stress and inflammation. | Sewon Lee Yoonjung Park Mozow Yusof Zuidema Mark Hannink | 2011 | World Journal of Cardiology2011，3，1： | 23 |
| 2 | Injectable bone-graft substitutes: Currentproducts,their characteristics and indications,and new develop-ments 显示文摘 | Larsson S Hannink G | 2011 | Injury2011，42，： | 1 |
| 3 | The reverse two-hybrid system: a genetic scheme for selection against specific protein/protein interactions 显示文摘 | LEANNA C A HANNINK M | 1996 | Nucleic Acids Res1996，24，17： | 1 |
| 4 | Dinstinct cysteine residues in keapl are required for keap-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress显示文摘 | Zhang D D Hannink M | 2003 | Mol Cell Biol2003，23，22： | 1 |
| 5 | Ceramic steel显示文摘 | Garvie R C Hannink R H Pascoe R T | 1975 | Nature1975，258，： | 1 |
| 6 | Long-term follow-up results of primary and recurrent pigmented villonodular synovitis 显示文摘 | Verspoor FG Zee AA Hannink G | 2014 | Rheumatology( Oxford)2014，53，11： | 1 |
| 7 | Transformation toughening in zirconia-containing ceramics显示文摘 | HANNINK H J KELLY P M MUDDLE B C | 2000 | Journal of the American Ceramic Society2000，83，3： | 1 |
| 8 | Sentinel node biopsy for squamous cell carcinoma of the oral cavity and oropharynx: a diagnostic meta-analysis 显示文摘 | Govers TM Hannink G Merkx MA | 2013 | Oral Oncol2013，49，8： | 1 |
| 9 | Ceramic steel显示文摘 | GARVIE R C HANNINK R H PASCOE R T | 1975 | Nature1975，258，5537： | 1 |
| 10 | Bioresorbability,porosity and mechanical streng-th of bone substitutes:what is o ptimal for bone reg eneration?显示文摘 | Hannink G Arts JJ | 2011 | Injury2011，42，2： | 1 |
| 11 | Eutectoid Decomposition of MgO-partially Stabilized ZrO2显示文摘 | S C Farmer A H Heuer R H J Hannink | 1987 | Journal of the American Ceramic Society1987，70，6： | 1 |
| 12 | Crystal structure of the Kelch domain of human Keapl显示文摘 | Li X Zhaug D Hannink M et ol | 2004 | J Biol Chem2004，279，54： | 1 |
| 13 | Structure and function of platelet - derived growth factor (PDGF) and related proteins 显示文摘 | HANNINK M DONOGHUE D J | 1989 | Biochim Biophys Acta1989，989，1： | 1 |
| 14 | Distinct cysteine residues in Keapl are required for Keapl-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress显示文摘 | Zhang DD Hannink M | 2003 | Mol Cell Biol2003，23，22： | 1 |
| 15 | Bioresorbability,porosity and mechanical strength of bone substitutes:what is optimal for bone regeneration显示文摘 | Hannink G Arts J J | | 0，，02： | 1 |
| 16 | Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin Dl-dependent cellular transformation 显示文摘 | ALT J R CLEVELAND J L HANNINK M | 2000 | Genes Dev2000，14，24： | 1 |
| 17 | Ceramic steel 显示文摘 | Garvie RC Hannink RH Pascoe RT | 1975 | Nature1975，258，： | 1 |
| 18 | Non-invasive ventilation abolishes the IL-6 nesponse to exercise in musclewasted COPD patients:a pilot study显示文摘 | Hannink JD van Hees HW Dekhuijzen PN | | 0，，01： | 1 |
| 19 | Ceramic steel显示文摘 | Garvie R C Hannink R H J Pascoe R T | 1975 | J Nature1975，258，： | 1 |
| 20 | Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1 - dependent cellular transformation 显示文摘 | Alt JR Cleveland JL Hannink M | 2000 | Genes Dev2000，14，24： | 1 |
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