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| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | HBsAg quantification for identification of liver disease in chronic hepatitis B virus carriers显示文摘 | Simon B. Larsson Anders Eilard Sebastian Malmstr?m Charles Hannoun Amar P. Dhillon Gunnar Norkrans Magnus Lindh | 2014 | Liver Int2014，，7： | 3 |
| 3 | Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation显示文摘 | Antoine Hannoun Ghina Ghaziri Antoine Abu Musa Tony G. Zreik Fatiha Hajameh Johnny Awwad | 2009 | Reproductive BioMedicine Online2009，，： | 2 |
| 4 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 2 |
| 5 | Comparative outcomes of rectal cancer surgery between elderly and non-elderly patients: a systematic review显示文摘 | Gilles Manceau Mehdi Karoui Andrew Werner Neil J Mortensen Laurent Hannoun | 2012 | Lancet Oncology2012，，12： | 2 |
| 6 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 7 | Development of the human pancreas: variations and pathology. A tentative classification显示文摘 | G. Adda L. Hannoun J. Loygue | 1984 | Anatomia Clinica1984，，4： | 1 |
| 8 | Immunogenicity and protective effi cacy of influenza vaccination显示文摘 | Hannoun C Megas F Piercy J | 2004 | Virus Research2004，103，： | 1 |
| 9 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carrier显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，： | 1 |
| 10 | Genotype mixtures of hepatitis B virus in patients treated with interferon显示文摘 | Hannoun C Krogsgaard K Horal P | 2002 | J Infect Dis2002，186，： | 1 |
| 11 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhion AP | 1999 | J Infect Dis1999，179，： | 1 |
| 12 | Long-term mutation rates in the hepatitis B virus genome显示文摘 | Hannoun C Horal P Lindh M | 2000 | J Gen Virol2000，81，1： | 1 |
| 13 | Immunogenicity and protective efficacy of influenza vaccination显示文摘 | Hannoun C Megas F Piercy J | 2004 | Virus Res2004，103，12： | 1 |
| 14 | Turbulence structure near a sharp density interface 显示文摘 | HANNOUN I A FERNANDO H J S LIST E J | 1988 | Journal of Fluid Mechanics1988，189，： | 1 |
| 15 | An aberrant genotype re- vealed in recombinant hepatitis B virus strains from Vietnam显示文摘 | HANNOUN C NORDER H LINDH M | 2000 | J Gen Virol2000，81，9： | 1 |
| 16 | An investigational ovarian stimulation protocol increased significantly the psychological burden in women with premature ovarian failure显示文摘 | AWWAD J T GHAZEERI G S HANNOUN A | 2012 | Acta Obstet Gynecol Scand2012，91，11： | 1 |
| 17 | Ex-situ in-vivo liver surgery显示文摘 | Hannoun L Panis Y Balladur P | 1991 | Lancet1991，337，8757： | 1 |
| 18 | Core promoter mutations and genotype in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 19 | Genotype mixtures of hepatitis B virus in patients treated with interferon显示文摘 | Hannoun C Krogsgaard K Horal P et al.Lindh M | | 0，，： | 1 |
| 20 | Turbulent mixing at a shear free density interface显示文摘 | HANNOUN I A LIST E J | 1988 | Journal of Fluid Mechanics1988，189，： | 1 |
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