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| 1 | A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population显示文摘Objective:Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility togastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rs1927914 T>C and rs10759932 T>C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rs10759932 had a significantly reduced risk of gastric cancer (adjusted OR=0.81; 95%CI=0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity >0.05). No significant association was observed between rs1927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings. | Hua Huang Juan Wu Guangfu Jin Hanze Zhang Yanbing Ding Zhaolai Hua Yan Zhou Yan Xue Yan Lu Zhibin Hu Yaochu Xu Hongbing Shen | 2010 | The Journal of Biomedical Research2010，24，2： | 5 |
| 2 | Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure显示文摘Acute liver failure(ALF),a fatal clinical disease featured with overwhelming hepatocyte necrosis,is a grand challenge in global health.However,a satisfactory therapeutic option for curing ALF is still absent,other than liver transplantation.Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF.The liver can sequester most of nanoparticles from blood circulation,which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases.Nanobiomaterials can enhance the bioavailability of free drugs,thereby significantly improving the therapeutic effects in ALF.Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells.In addition,stimuli-responsive,optical,or magnetic nanomaterials exhibit great potential in the therapeutical,diagnostic,and imaging applications in ALF.Therefore,therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy,diminish adverse systemic effects,and offer a multifunctional theranostic platform.Nanobiomaterial holds excellent significance and prospects in ALF theranostics.In this review,we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF.We highlight recent developments of diverse nanomedicines for ALF therapy,diagnosis,and imaging.Furthermore,the challenges and future perspectives in the theranostics of ALF are also discussed. | Yuanyuan Jin Haixia Wang Ke Yi Shixian Lv Hanze Hu Mingqiang Li Yu Tao | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 3 | Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses显示文摘Dear Editor,The emergence of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection requires rapid development of vaccines matching the pace of virus mutation.While the firstgeneration of nucleic acid vaccines have been successful,subunit vaccines carry far fewer safety concerns and also have shown promise in clinical trials. | Xuenian Chen Tongfei Shi Chao Yang Fangman Chen Xuan He Kunbao Zhang Hanze Hu Lulu Cai Kam WLeong Dan Shao | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
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