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| 1 | Efficient degradation of organic pollutants by S-NaTaO_(3)/biochar under visible light and the photocatalytic performance of a permonosulfate-based dual-effect catalytic system显示文摘Removing large concentrations of organic pollutants from water efficiently and quickly under visible light is essential to developing photocatalytic technology and improving solar energy efficiency.This study used a simple hydrothermal method to prepare a non-metallic,S-doped NaTaO_(3)(S-NTO) photocatalyst,which was then loaded onto biochar (BC) to form a S-NTO/BC composite photocatalyst.After uniform loading onto BC,the S-NTO particles transformed from cubic to spherical.The photogenerated electron-hole pair recombination probability of the composite photocatalyst was significantly lower than those of the NTO particles.The light absorption range of the catalyst was effectively widened from 310 nm UV region to visible region.In addition,a dual-effect catalytic system was constructed by introducing peroxymonosulfate (PMS) into the environment of the pollution to be degraded.The Rhodamine B,Methyl Orange,Acid Orange 7,tetracycline,and ciprofloxacin degradation efficiency at 40 mg/L reached 99.6%,99.2%,84.5%,67.1%,and 70.7%,respectively,after irradiation by a 40 W lamps for 90 min.The high-efficiency visible-light catalytic activity of the dual-effect catalytic system was attributed to doping with non-metallic sulfur and loading of catalysts onto BC.The development of this dual-effect catalytic system provides new ideas for quickly and efficiently solving the problem of high-concentration organic pollution in aqueous environments,rationally and fully utilizing solar energy,and expanding the application of photocatalytic technology to practice. | Yuehui Tai Jinlong Sun Haoran Tian Fuyue Liu Boyu Han Wei Fu Zhangpei Liu Xiuye Yang Qifeng Liu | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 2 | miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD^(+)/SIRT inactivation显示文摘Nicotinamide adenine dinucleotide(NAD^(+))is indispensable for the anti-aging activity of the sirtuin(SIRT)family enzymes.AMPactivated protein kinase(AMPK)upregulates NAD^(+)synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase(NAMPT)-dependent manner.However,the molecular mechanisms that affect AMPK-driven NAMPT expression and NAD^(+)/SIRT activation remain unclear.In this study,we tried to identify senescence-associated microRNAs(miRNAs)that negatively regulate the cascade linking AMPK and NAMPT expression.miRNA-screening experiments showed that the expression of miR-146a increased in senescent cells but decreased following AMPK activation.Additionally,miR-146a overexpression weakened the metforminmediated upregulation of NAMPT expression,NAD^(+)synthesis,SIRT activity,and senescence protection,whereas treatment with the miR-146a inhibitor reversed this effect.Importantly,these findings were observed both in vitro and in vivo.Mechanistically,miR146a directly targeted the 3′-UTR of Nampt mRNA to reduce the expression of NAMPT.AMPK activators metformin and 5-aminoimidazole-4-carboxamide(AICAR)hindered miR-146a expression at the transcriptional level by promoting IκB kinase(IKK)phosphorylation to attenuate nuclear factor-kappaB(NF-κB)activity.These findings identified a novel cascade that negatively regulates the NAD^(+)/SIRT pathway by suppressing miR-146a-mediated NAMPT downregulation.Furthermore,our results showed that miR-146a impedes the anti-aging effect of AMPK.This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD^(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases. | Hui Gong Honghan Chen Peng Xiao Ning Huang Xiaojuan Han Jian Zhang Yu Yang Tiepeng Li Tingting Zhao Haoran Tai Weitong Xu Gongchang Zhang Chuhui Gong Ming Yang Xiaoqiang Tang Hengyi Xiao | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 3 | SeHed,a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect显示文摘Dear Editor,The moderate level of reactive oxygen species(ROS)contributes to cellular functions such as proliferation,differentiation,and infection resistance,but the excessive level of ROS causes oxidative damage which underlies the basic mechanism for aging and geriatric diseases.1 Therefore,precisely managing cellular ROS levels,meaning to keep redox homeostasis properly,stands as an aim for health and longevity.Actually,this aim is challenging,as it asks not only to restrain excessive ROS accumulation at the right time and right place but also to guarantee proper ROS levels for fitting physiological requirements.Traditional ways for eliminating ROS put more attention on the efficiency and identified a variety of drugs and enzymes with antioxidant properties,known as enzymatic and non-enzymatic ROS scavengers,respectively.However,how to accurately manage the integrative effect of ROS scavengers in vivo remains a problem.Actually,the effectiveness of non-enzymatic antioxidants in vivo is controversial,explained mostly by the uncertainty to reach a given organ with the appropriate concentration or to work there persistently.2 As to enzymatic ROS scavengers,although their overexpression in a given place can be achieved,this mode is often unwieldy or harmful to intrinsic physiologic functions in cases.3 For this reason,we attempt to develop new ways for in vivo antioxidation,for establishing a high-quality balance between efficiency and safety.As the consequence,we innovated a gene expression system that can limit the excessive ROS accumulation but keep the physiological level of ROS. | Ning Huang Honghan Chen Hui Gong Haoran Tai Xiaojuan Han Xiaobo Wang Chuhui Gong Tingting Zhao Yu Yang Hengyi Xiao | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
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