| 1 | Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care显示文摘Human papillomavirus(HPV)infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers.Up to 38%–80%of head and neck squamous cell carcinoma(HNSCC)in oropharyngeal location(OPSCC)and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and E7.Given by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors,clinical trials on de-escalation treatment strategies for these patients have been studied.It is therefore raised the questions for the patient stratification if treatment de-escalation is feasible.Moreover,understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the proportional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substantially improve the treatment efficacy.This review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future directions.With the advent of various sequencing technologies,further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care. | Haoru Dong Xinhua Shu Qiang Xu Chen Zhu Andreas M.Kaufmann Zhi-Ming Zheng Andreas E.Albers Xu Qian | 2021 | Virologica Sinica2021，36，6： | 1 |
| 2 | Nanomaterials for neurodegenerative diseases:Molecular mechanisms guided design and applications显示文摘Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine. | Tianzhong Li Xueyan Hou Yu Qi Xiaohan Duan Pengcheng Yan Haoru Zhu Zhongjian Xie Han Zhang | 2022 | Nano Research2022，15，4： | 0 |
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