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| 1 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 2 | Transcriptional regulation of the macrophage-induced gene(gspA)of Legionella pneumophila and phenotypic characterization of a null mutant显示文摘 | Gao LY Harb O S | 1997 | Mol Microbiol1997，24，： | 1 |
| 3 | EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions 显示文摘 | Marleau S Harb D Bujold K | 2005 | Faseb J2005，19，13： | 1 |
| 4 | Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant hosts,mammalian and protozoa显示文摘 | Harb O S Abu Kwaik Y | 1997 | Infect Immun1997，65，： | 1 |
| 5 | Identification of macrophage-specific infectivity loci(mil)of legionella pneumophila that are not required for infectivity of protozoa显示文摘 | Harb O S Abu Kwaik Y | 1998 | Infect Immun1998，66，： | 1 |
| 6 | Identification of macrophage-specific infectifity loci(mil)of Legionella pneumophila that are not lequired for infectivity of protozoa显示文摘 | Harb O S Abu Kwaik Y | 1998 | Infect Immun1998，66，： | 1 |
| 7 | Measurement of the Radioactivity of 238U,226Ra,210Pb,228Th,232Th,228Ra,137Cs and 40K in Tea Using Gamma-Spectrometry显示文摘 | Harb S | | 0，，： | 1 |
| 8 | Power decoupling techniques for micro-inverters in PV systems-a review 显示文摘 | Hu Haibing Harb S Kutkut N | 2010 | IEEE Energy Conversion Congress and Exposition2010，，： | 1 |
| 9 | A VLSI high-performance priority encoder using standard CMOS library 显示文摘 | Abdel Hafeez S Harb S | 2006 | IEEE Transactions on Circuits and Systems II: Express Briefs2006，53，8： | 1 |
| 10 | Wave function microscopy of quasibound atomic states 显示文摘 | Cohen S Harb M M Ollagnier A | 2013 | Physical Review Letters2013，110，18： | 1 |
| 11 | Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated显示文摘 | Echeverria P C Matrajt M Harb O S | 2005 | J Mol Biol2005，350，4： | 1 |
| 12 | EP80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficlent mice from developing atherosclerotic lesions 显示文摘 | Marleau S Harb D Bujold K | 2005 | FASEB2005，19，： | 1 |
| 13 | Yersinia enterocolitica impairs activation of transcription factor NF kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production显示文摘 | Ruckdeschel K Harb S Roggenkamp A | 1998 | J ExpMed1998，187，7： | 1 |
| 14 | A multi-resolution FPCA-based architecture for real-time edge and corner detection 显示文摘 | POSSA P R MAHMOUDI S A HARB N | 2013 | IEEE Transactions on Computers2013，63，8： | 1 |
| 15 | Natural radioactivity and their radiological effects for different types of rocks from Egypt显示文摘 | Harb S Abbady AE E1-Kamel AE | | 0，，03： | 1 |
| 16 | Subnanometer behavior of a capacitive feedback, piezoelectric displacement actuator显示文摘 | Harb S Smith S T Chetwynd D G | 1992 | Review of Scientific Instruments1992，63，2： | 1 |
| 17 | Toxoplasma gondii Hsp90 is a potential drug tar- get whose expression and subcellular localization are developmentally regulated 显示文摘 | ECHEVERRIA P C MATRAJT M HARB O S | 2005 | J Mol Biol2005，350，4： | 1 |
| 18 | Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals显示文摘BACKGROUND In resource-limited countries,risk stratification can be used to optimize colorectal cancer screening.Few prospective risk prediction models exist for advanced neoplasia(AN)in true average-risk individuals.AIM To create and internally validate a risk prediction model for detection of AN in METHODS Prospective study of asymptomatic individuals undergoing first screening colonoscopy.Detailed characteristics including diet,exercise and medications were collected.Multivariate logistic regression was used to elucidate risk factors for AN(adenoma≥1 cm,villous histology,high-grade dysplasia or carcinoma).The model was validated through bootstrapping,and discrimination and calibration of the model were assessed.RESULTS 980 consecutive individuals(51%F;49%M)were enrolled.Adenoma and AN detection rates were 36.6%(F 29%:M 45%;P<0.001)and 5.1%(F 3.8%;M 6.5%)respectively.On multivariate analysis,predictors of AN[OR(95%CI)]were age[1.036(1.00-1.07);P=0.048],BMI[overweight 2.21(0.98-5.00);obese 3.54(1.48-8.50);P=0.018],smoking[<40 pack-years 2.01(1.01-4.01);≥40 pack-years 3.96(1.86-8.42);P=0.002],and daily red meat consumption[2.02(0.92-4.42)P=0.079].Nomograms of AN risk were developed in terms of risk factors and age separately for normal,overweight and obese individuals.The model had good discrimination and calibration.CONCLUSION The prevalence of adenoma and AN in average-risk Lebanese individuals is similar to the West.Age,smoking,and BMI are important predictors of AN,with obesity being particularly powerful.Though external validation is needed,this model provides an important platform for improved risk-stratification for screening programs in regions where universal screening is not currently employed. | Ala I Sharara Ali El Mokahal Ali H Harb Natalia Khalaf Fayez S Sarkis Mustapha M El-Halabi Nabil M Mansour Ahmad Malli Robert Habib | 2020 | World Journal of Gastroenterology2020，26，37： | 1 |
| 19 | Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction显示文摘 | Harb T S Zareba W Moss A J | 2002 | AM J Cardiol2002，89，： | 1 |
| 20 | Integrative genomic ap- proaches highlight a family of parasi'~e-specific kinases that regu- late host responses 显示文摘 | Peixoto L Chen F Harb O S | 2010 | Cell Host Microbe2010，8，2： | 1 |
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