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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | A peptide antibiotic from human skin显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 1997 | Nature1997，387，6636： | 1 |
| 3 | Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic 显示文摘 | Harder J Bartels J Christophers E | 2001 | J Biol Chem2001，276，8： | 1 |
| 4 | First identification and functional characterization of an immunogenic protein in unculturable haemotrophic mycoplasmas(Mycoplasma suis Hsp A1)显示文摘 | HOELZLE L E HOELZLE K HARDER A | 2007 | FEMS Immunol Med Microbiol2007，49，2： | 1 |
| 5 | A peptide antibiotic from human skin显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 1997 | Nature1997，387，6636： | 1 |
| 6 | The costs and benefits of large-scale solar photovoltaic power production in Abu Dhabi, United Arab Emirates显示文摘 | Harder E Gibson J M D | 2011 | Renewable Energy2011，36，2： | 1 |
| 7 | Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic 显示文摘 | Harder J Bartels J Christophers E | 2001 | J Biol Chenm2001，276，8： | 1 |
| 8 | Isolation and characterization of human beta-defensin-3,a novel human inducible peptide anti-biotic显示文摘 | Harder J Bartels J Christophers E | 2001 | J Biol Chem2001，276，8： | 1 |
| 9 | A peptide antibiotic from human,skin显示文摘 | Harder J Bartels E Christophers E | 1997 | Nature1997，387，6636： | 1 |
| 10 | Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals显示文摘 | Andersson E A Pilgaard K Pisinger C Harder M N Grarup N Faerch K Sandholt C Poulsen P Witte D R Jorgensen T Vaag A Pedersen O and Hansen T | | 0，，12： | 1 |
| 11 | Acute and chronic presentation of intestinal nonrotation in adults显示文摘 | Markus Flüe M.D. Urs Herzog M.D. Christoph Ackermann M.D. Peter Tondelli M.D. Felix Harder M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 1 |
| 12 | Isolation and characterization of human beta-defensin-3,a noval human inducible peptide antibiotic显示文摘 | Bartels J Christophers E | 2001 | J Biol Chem2001，276，8： | 1 |
| 13 | A peptide antibiotic from human skin显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 1997 | Nature1997，387，： | 1 |
| 14 | A peptidc antibiotic from humanskin显示文摘 | Harder J Bartels J Christophers E | 1997 | Nature1997，387，6： | 1 |
| 15 | Isolation and characterization of human beta - defensin - 3, a novel human induc- ible peptide antibiotic显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 2001 | J Biol Chem2001，276，8： | 1 |
| 16 | Transanal endosenpic microsurgical excision of rectal tumors indications and results 显示文摘 | Demartines N von Fl u e MO Harder FH | 2001 | World J Surg2001，25，7： | 1 |
| 17 | Birth weight and subsequent risk of type 2 diabetes:ameta-analysis 显示文摘 | Harder T Rodekamp E Schellong K | 2007 | Am J Epidemiol2007，165，8： | 1 |
| 18 | Isolation and characterization of human beta-defensin-3,a novel human inducible peptide antibiotic显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 2001 | J Biol Chem2001，276，8： | 1 |
| 19 | Isolation and characterization of human β-defensin-3,a novel human inducible peptide antibiotic显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 2001 | J Biol Chem2001，276，8： | 1 |
| 20 | Isolation and characterization of human beta defensin 3, anovel human inducible peptide antibiotic显示文摘 | Harder J Bartels E Christophers JM | 2003 | Biochem2003，276，8： | 1 |
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