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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Review methylotrophic yeasts as factories for the production of foreign proteins显示文摘 | Faber KN Harder W Ab G | 1995 | Yeast1995，11，14： | 2 |
| 3 | Correlation between clinical, angiographic and transcranial Doppler sonographic findings in patients with moyamoya disease显示文摘 | Harders A Klimex L | 1993 | Neurol Res1993，15，： | 1 |
| 4 | Perinatal ‘programming' of insulin resistance in childhood: critical impact of neonatal insulin and low birth weight in a risk population显示文摘 | Harder T Kohlhoff R Domer G | 2001 | Diabet Med2001，18，8： | 1 |
| 5 | Correlation between clinical,angiographic and transcranial Doppler sonographic findings in patients with moyamoya disease显示文摘 | Harder S Klimek L | 1993 | Neurol Res1993，15，： | 1 |
| 6 | Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer显示文摘 | Harder J Ihorst G Heinemann V | 2012 | BrJ Cancer2012，106，6： | 1 |
| 7 | Connecting the Dots : Social Software and the Social Nature of Libraries显示文摘 | Harder G | 2006 | Feliciter2006，52，2： | 1 |
| 8 | Brain activity and blood flow velocity changes:a transcranial Doppler study显示文摘 | Harders AG Laborde G Droste DW | 1989 | Int J Neurosci1989，47，： | 1 |
| 9 | Classification of agents with anticoccidial activity into various subgroups on the basis of their mechanisms of action 显示文摘 | Gisela G Harder A Haberkorn A | 2001 | Parasitology Research2001，87，11： | 1 |
| 10 | Methylotrophic yeasts as factories for the production of foreign proteins显示文摘 | FABER K N HARDER W AB G | 1995 | J Yeast1995，11，14： | 1 |
| 11 | Stem cell plasticity in mammals and transdetermination in Drosophila显示文摘 | Wei G Schubiger G Harder F | 2000 | Stem Cells2000，18，6： | 1 |
| 12 | Stem cell plasticity in mammals and transdetermination in Drosophila: common themes显示文摘 | WEI G SCHUBIGER G HARDER F | 2000 | Stem Cells2000，18，6： | 1 |
| 13 | Stem cell plasticity in mammals and transdetermination in Drosophila:common themes?显示文摘 | WEI G SCHUBIGER G HARDER F | 2000 | Stem Cells2000，18，6： | 1 |
| 14 | Regulation of methanol metabolism in the yeast Hansenula polymorpha显示文摘 | W de koning M A G Gleeson W Harder | 1987 | Arch Microbiol1987，147，： | 1 |
| 15 | Computer assisted localizer for planning of surgery and interaoperative显示文摘 | Gilsbach J Harders A | 1992 | Acta Neurochir1992，119，14： | 1 |
| 16 | Correlation between clinical, angiographic and transcranial Dopp ler sonographic findings in patientswith moyamoya disease 显示文摘 | Laborde G Harders A Klimek L | 1993 | Neurol Res1993，15，： | 1 |
| 17 | Sensory evaluation by gamma radiation effect on protein allergen of laying hen eggs 显示文摘 | Harder M N C Arthur V Perina V C S Silva L C A S Bortoleto G G | 2012 | Radiation Physics and Chemistry2012，81，8： | 1 |
| 18 | Correlation between clinical, angiographic and transcranial Doppler sonographic findings in patients with moyamoya disease显示文摘 | Laborde G Harders A Klimek L | 1993 | Neurol Res1993，15，2： | 1 |
| 19 | Review: methylotrophic yeasts as factories for the production of foreign proteins 显示文摘 | Faber K N Harder W Ab G | 1995 | Yeast1995，11，14： | 1 |
| 20 | Quantitative analysis of ITS2 sequences in tiichostrongyle parasites显示文摘 | von Samson-Himmelstjerna G Harder A Schnieder T | 2002 | International Journal for Parasitology2002，32，12： | 1 |
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