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| 1 | Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases显示文摘The current therapeutic regimen to combat chronic hepatitis C is not optimal due to substantial side effects and the failure of a significant proportion of patients to achieve a sustained virological response.Recently developed direct-acting antivirals targeting hepatitis C virus(HCV)enzymes reportedly increase the virologic response to therapy but may lead to a selection of drug-resistant variants.Besides directacting antivirals,another promising class of HCV drugs in development include host targeting agents that are responsible for interfering with the host factors crucia for the viral life cycle.A family of host proteins known as DEAD-box RNA helicases,characterized by nine conserved motifs,is known to play an important role in RNA metabolism.Several members of this family such as DDX3,DDX5 and DDX6 have been shown to play a role in HCV replication and this review will summarize our current knowledge on their interaction with HCV.As chronic hepatitis C is one of the leading causes of hepatocellular carcinoma,the involvement of DEADbox RNA helicases in the development of HCC will also be highlighted.Continuing research on the interaction of host DEAD-box proteins with HCV and the contribution to viral replication and pathogenesis could be the panacea for the development of novel therapeutics against HCV. | Megha Haridas Upadya Jude Juventus Aweya Yee-Joo Tan | 2014 | World Journal of Gastroenterology2014，20，11： | 6 |
| 2 | Efficacy of boswellic acid on lysosomal acid hydrolases,lipid peroxidation and anti-oxidant status in gouty arthritic mice显示文摘Objective:To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice.Methods:The mice were divided into four experimental groups.GroupⅠserved as control;mice in groupⅡwere injected with monosodium urate crystal;groupⅢconsisted of monosodium urate crystal-induced mice who were treated with boswellic acid(30mg/kg/b.w.);groupⅣcomprised monosodium urate crystal-induced mice who were treated with indomethacin(3mg/kg/b.w.).Paw volume and levels/activities of lysosomal enzymes,lipid peroxidation,anti-oxidant status and inflammatory mediator TNF-αwere determined in control and monosodium urate crystal-induced mice.In addition,the levels ofβ-glucuronidase and lactate dehydrogenase were also measured in monosodium urate crystal-incubated polymorphonuclear leucocytes(PMNL)in vitro.Results:The activities of lysosomal enzymes,lipid peroxidation,and tumour necrosis factor-αlevels and paw volume were increased significantly in monosodium urate crystal-induced mice,whereas the activities of antioxidant status were in turn decreased.However,these changes were modulated to near normal levels upon boswellic acid administration.In vitro,boswellic acid reduced the level ofβ-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated PMNL in concentration dependent manner when compared with control cells.Conclusions:The results obtained in this study further strengthen the anti-inflammatory/antiarthritic effect of boswellic acid,which was already well established by several investigators. | Evan Prince Sabina Haridas Indu Mahaboobkhan Rasool | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 3 | Lipid enhancement in microalgae by temporal phase separation:Use of indigenous sources of nutrients显示文摘Microalgae have been recommended as superior candidate for fuel production because of their advantages of higher photosynthetic efficiency, biomass & lipid productivity, and faster growth rate as compared to other energy crops. To meet up all these criteria, we have developed a continuous outdoor micro-algal raceway pond reactor(RPR) and a lab scale indoor tubular photo bioreactor(PBR) for biofuel production. An attempt to utilise indigenous sources of nutrients to improve the economics also revealed that micro-algal culturing can also be used as a mode of nutrient removal and water treatment. The photosynthetic rate and lipid production were enhanced by arresting daytime cell division and promoting night-time cell division. A 50% lipid improvement was observed for the particular algal consortia. Microscopic studies revealed that temporal phase separation could be achieved by adjusting nutrient distribution pattern. To monitor temporal phase separation, it is required to know DNA multiplication model. Quantification of g DNA in RPR confirmed that cell division happens during the night which positively affects the photosynthetic efficiency and lipid productivity of microalgae. | Nidhin Sreekumar Ajit Haridas G.S.Godwin N.Selvaraju | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 2 |
| 4 | CD70^+ anti gen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa显示文摘 | Laouar A Haridas V Vargas D | 2005 | Nat Immunol2005，6，： | 1 |
| 5 | Self-assembling aromatic-bridged serine-based cyclodepsipeptides(serinophanes):A demonstration of tubular structures formed through aromatic-interactions显示文摘 | Ranganathan D Haridas V Gilasdi R | 1998 | J Am Chem Soc1998，120，10： | 1 |
| 6 | Cytokine re-sponse in children undergoing surgery for congenital heart disease 显示文摘 | MADI-IOK A B 0 JAMAA K HARIDAS V | 2006 | Pediatr Cardiol2006，27，4： | 1 |
| 7 | Primary carcinoid of posterior mediastinum:truth or myth!显示文摘 | Joshi S Haridas A Rout PL | 2010 | Indian J Chest Dis Allied Sci2010，52，4： | 1 |
| 8 | Matrix metalloproteinases and their inhibitors:correlation with invasion and metastasis in oral cancer显示文摘 | Singh RD Haridas N Patel JB | | 0，，03： | 1 |
| 9 | Inactivation of lipase and lipoxygenase in cereal bran, germand soybean by microwave treatment 显示文摘 | VETRINANI R JYOTHIRMAYI N HARIDAS R P | 1992 | Food Science and Technology1992，25，6： | 1 |
| 10 | Preoperative findings predict conversion from Iaparoscopic to open cholecystectomy 显示文摘 | Lipman JM Claridge JA Haridas M | 2007 | Surgery2007，142，4： | 1 |
| 11 | Removal of phosphate from aqueous solutions and sewage using natural and surface modified coir pith显示文摘 | Krishnan K A Haridas A | 2008 | Journal of Hazardous Materials2008，152，2： | 1 |
| 12 | TRANK, a novel cytokine that activates NF-kappaB and c-Jun N-terminal kinase 显示文摘 | Haridas V Ni J Meager A | 1998 | J Immunol1998，161，1： | 1 |
| 13 | Avicins:triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation显示文摘 | Haridas V Higuchi M Jayatilake G S | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 14 | Pathobiological implications of MUCl6 expression in pancreatic cancer 显示文摘 | Haridas D Chakraborty S Ponnusamy MP | 2011 | PloS One2011，6，26： | 1 |
| 15 | Study of collective efforts of catalytic activity and photoactivation to enhance room temperature re- sponse of SnO2 thin film sensor for methane显示文摘 | Haridas D Gupta V | 2013 | Sensors Ac- tuators B: Chem2013，182，： | 1 |
| 16 | Effect of damage starch on the ehapatti-making quality of whole wheat flour显示文摘 | Haridas R P Leelavathe K | 1989 | Cereal Chemistry1989，66，： | 1 |
| 17 | Preoperative findings predict conversion from laparoscopic to open cholecystectomy显示文摘 | Jeremy M. Lipman Jeffrey A. Claridge Manjunath Haridas Matthew D. Martin David C. Yao Kevin L. Grimes Mark A. Malangoni | 2007 | Surgery2007，，4： | 1 |
| 18 | Evaluation of clinical utility of serum enzymes and troponin—T in the early stages of acute myocardial infarction显示文摘 | Hitesh Shah N. Haridas | 2003 | Indian Journal of Clinical Biochemistry2003，，2： | 1 |
| 19 | Chordoma presenting as pseudoprolactinoma 显示文摘 | Haridas A Ansari S Afshar F | 2003 | Br J Neurosurg2003，17，： | 1 |
| 20 | Influence of additives on the rheological characteristics and baking quality of wheat flours显示文摘 | Ravi R Manohar R Haridas P | 2000 | European Food Res and Tech2000，210，3： | 1 |
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