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| 1 | 端粒酶和癌症治疗显示文摘端粒酶是一个有吸引力的癌症靶标,它是所有癌症亚类细胞,包括癌干细胞,永生化所必需的成分。而且,在正常和肿瘤组织之间,端粒酶表达、端粒长度和细胞动力学存在明显的差异,提示靶向端粒酶可能相当安全。GRN163L,一种强而特异的端粒酶抑制剂,正与几种端粒酶治疗疫苗一起进行临床试验。基于端粒酶的新癌症候选药虽充满希望,但该治疗方法的局限性、优点以及哪种患者更适合等问题尚待探讨。 | 魏霞 黄世杰 Harley CB | 2008 | 国际药学研究杂志2008，35，5： | 7 |
| 2 | Telomerase shorten during aging of human fibroblasts 显示文摘 | Harley CB Futcher AB Greider CW | 1990 | Nature1990，345，： | 1 |
| 3 | Telomeres shorten during aging of human fibrofasts显示文摘 | Harley CB Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
| 4 | Telomeres shorten duing ageing of human fibrofasts显示文摘 | HarLey CB Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
| 5 | Telomeres shorten during ageing of human fibroblasts显示文摘 | Harley CB Futcher AB Creider CW | 1990 | Nature1990，345，6274： | 1 |
| 6 | Telomeres shorten during ageing of human fibroblasts显示文摘 | Harley CB Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
| 7 | Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65 kDa mycobacterial antigen 显示文摘 | Jindal S Dudani AK Harley CB | 1989 | Mol Cell Biol1989，9，： | 1 |
| 8 | Telomeres shorten during ageing of human fibroblasts显示文摘 | Harley CB Futcher AB Greider CW | | 0，，6274： | 1 |
| 9 | Replicative senescence and cell immortality:the role of telomeres and telomerase显示文摘 | Harley CB | 1997 | Proc Soc Exp Biol Med1997，214，： | 1 |
| 10 | Telomerase is not an oncogene显示文摘 | Harley CB | 2002 | Oncogene2002，21，4： | 1 |
| 11 | Telomerase,cell immortality and cancer显示文摘 | Harley CB Kim NW Prowse KR | 1994 | Cold Spring Hanbor1994，66，： | 1 |
| 12 | Telomere loss: mitotic clock or genetic time bomb显示文摘 | Harley CB | 1991 | ? Mutat Res1991，256，26： | 1 |
| 13 | Telomeres shorten during ageing of human fibroblasts显示文摘 | Harley CB Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
| 14 | Human ageing and telomeres 显示文摘 | Harley CB | 1997 | Ciba Found Symp1997，211，1： | 1 |
| 15 | Telomeres shorten during ageing of human libroblasts 显示文摘 | Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
| 16 | Telomerase activity in normal leukocytes and in hematoolgic malignanices显示文摘 | Counter CM Gupta J Harley CB | 1995 | Blood1995，85，： | 1 |
| 17 | Telomere shorten during aging of human fibroblast显示文摘 | Harley CB Fucher AB Cretder CW | 1990 | Nature1990，345，： | 1 |
| 18 | Telomerase is not an oncogene显示文摘 | Harley CB | 2002 | Oncogene2002，21，4： | 1 |
| 19 | Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65 kDa mycobacterial antigen显示文摘 | Jindal S Dudani AK Harley CB | 1989 | Mol Cell Biol1989，9，5： | 1 |
| 20 | Telomeres shorten during age- ing of human fibroblasts 显示文摘 | Harley CB Futcher AB Greider CW | 1990 | Nature1990，345，6274： | 1 |
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