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33篇 您的检索式：作者名="Harling G"

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	题名	作者	年代	出处	被引量
1	Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients.	Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen	2019	Cellular & Molecular Immunology2019，16，3：	15
2	Cloning of two zebrafish cDNA that share domains with the MHC class Ⅱ-associated invariant chain显示文摘	Yoder J A Harle R N Litman G W	1999	Immunogenetics1999，50，：	1
3	Lethal and sublethal effects of imidacloprid on nicotine-tolerant Myzus nicotianae and Myzus persicae显示文摘	Divane G J Harling Z K Scarr A W	1996	Pestic Sci1996，48，1：	1
4	Fibre optic temperature sensor using spectral modulation 显示文摘	Harl J C Saaski E W Mitchell G L		Fibre Optics and Laser Sensors V SPIE 1 9870，838，：	1
5	Lethal and sublethal effects of imidacloprid on nicotine-tolerant Myzus nicotianae and Myzus persicae 显示文摘	Devine G J Harling Z K Scarr A W	1996	Pestic Sci1996，48，1：	1
6	Income ine- quality and sexually transmitted in the United States: who bears the burden? 显示文摘	Harling G Subramanian SV Barnighausen T	2014	Soc Sci Med2014，102，：	1
7	Lethal and sublethal effects of imidacloprid on nicotine tolerant Myzus nicotianae and Myzus pericae显示文摘	Devine G J Harling Z K Scarr A W	1996	Pstic Sci1996，48，：	1
8	Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited显示文摘	Orrell C Harling G Lawn SD	2007	Antivir Ther2007，12，1：	1
9	The sympathetic nervous system stimulates collagen-induced arthritis (CIA) in the induction phase and inhibits CIA in the late effeetor phase in DBA- 1 mice显示文摘	Harle P Pongratz G Straub R H	2003	Arthritis Rheum2003，48，：	1
10	Bladder cancer among hairdressers: a meta-analysis 显示文摘	Harling M Schablon A Schedlbauer G	2010	Occup Environ Med2010，67，5：	1
11	The social epidemiology of tuberculosis in South Africa: a multilevel analysis显示文摘	HARLING G EHRLICH R MYER L	2008	Social Science and Medicine2008，66，2：	1
12	Measurement and modelling of the land mobile satellite channel at ku-band显示文摘	Scalise S Ernst H Harles G	2008	IEEE Transactions on Vehicular Januray2008，，：	1
13	Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis显示文摘	Harle P Pongratz G Weidler C	2004	Ann Rheum Dis2004，63，7：	1
14	Incidengtal Sadness Biases Social Economic Decisions in the Ultimatum Game 显示文摘	Harle K M Sanfey A G	2007	Emotion2007，7，4：	1
15	Lethal and sublethal effects of imidacloprid on nicotine-tolerant Myzus nicotianae and Myzus persicae显示文摘	DEVINE G J HARLING Z K SCARR A W	1996	Pesticide Science1996，48，1：	1
16	Incidental sadness biases social economic decisions in the Ultimatum Game显示文摘	Harle K M Sanfey A G	2007	Emotion2007，7，4：	1
17	Some effects of the addition of cobalt to the nickel hydroxide 显示文摘	RMSTONG R D RIGGS G W HARLES E A	1998	J Appl Electrochem1998，18，：	1
18	Structure in the neutron scattering spectra of zirconium hydride显示文摘	Couch J G Harling O K Lavern C Clune	1971	Physical Review B1971，4，8：	1
19	A nuclear-spin based rotation sensor using optical polarization and detection methods显示文摘	Harle P Wackerle G Mehring M	1993	Appl Magn Reso1993，5，2：	1
20	The impact of depression on social economic decision making显示文摘	Harle K M Allen J J Sanfey A G	2010	Joumal of Abnormal Psychology2010，119，2：	1

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