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| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | Physiological activity during a prolonged mental stress task : evidence for a shift in the control of pressor reactions 显示文摘 | Carroll D Cross G Harris MG | 1990 | Psychophysiology1990，4，3： | 1 |
| 3 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 4 | Chronic consumptive coagulopathy with a uterine leiomyoma显示文摘 | Harris MG Bannatyne P Russell P | 1982 | Aust N Z J Obstet Gynaecol1982，22，1： | 1 |
| 5 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 6 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth 显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 7 | The M2 splice isoform of Pyruvate kinase is important for cancer metabolism and tumor growth显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 8 | Dengue显示文摘 | Guzman MG Harris E | 2015 | Lancet2015，385，9966： | 1 |
| 9 | Monovision contact lens wear and occupational task performance显示文摘 | Sheedy JE Harris MG Busby L | 1988 | Am J Optom Physiol Opt1988，65，1： | 1 |
| 10 | The M2 splice isoform of pyruvate kinase is important for cancer metabo- lism and tumour growth显示文摘 | Christotk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 11 | Dengue 显示文摘 | Guzman MG Harris E | 2015 | Lancet2015，385，9966： | 1 |
| 12 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth 显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，： | 1 |
| 13 | Vision and task performance with monovision diffractive bifocal contact lens 显示文摘 | Harris MG Sheedy JE Gan CM | 1992 | Optom Vis Sci1992，69，： | 1 |
| 14 | The M2 splice isoform of pyruvate kinase is important for cancer metabo- lism and tumour growth显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 15 | The M2 splice isoform of pyruvate kinase is important for canc- er metabolism and tumour growth 显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 16 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth显示文摘 | Christofk HR Vander Heiden MG Harris MH | 2008 | Nature2008，452，7184： | 1 |
| 17 | Renal arteriovenous anerurysm in a 4-year old patient显示文摘 | Chauvapun JP Caty MG Harris LM | 2005 | Vas Surg2005，41，： | 1 |
| 18 | The relationship between duration of untreated psychosis an d outcome:an eight-year prospective study显示文摘 | Harris MG Henry LP Harrigan SM | 2005 | Schizophr Res2005，79，1： | 1 |
| 19 | Heritability of craniofacial and occlusal variables: a longitudinal sib analysis 显示文摘 | Harris EF Johnson MG | 1991 | Am J Orthod1991，99，： | 1 |
| 20 | Clinicolegal considerations of monovision显示文摘 | Harris MG Classe JG | 1988 | J Am Optom Assoc1988，59，6： | 1 |
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