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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction显示文摘 | O'Connor CM Glassman AH Harrison DJ | 2005 | J Clin Psychiatry2005，66，3： | 1 |
| 3 | Increasing age does not affect good outcome after lumbar disc replacement显示文摘 | Sott AH Harrison DJ | | 0，，01： | 1 |
| 4 | Endogenousanxiety and stress responses in water maze and Barnes mazespatial learning tasks 显示文摘 | Harrison FE Hosseini AH McDonald MP | 2009 | Behav Brain Res2009，198，： | 1 |
| 5 | Quality of residual oil from palm - pressed mesocarp fiber (elaeis guineensis) using supercritical CO2 with and without ethanol显示文摘 | Harrison Lik Nang Lau Yuen May Choo Ah Ngan Ma | 2006 | Journal of the American Oil Chemists'' Society2006，83，10： | 1 |
| 6 | Lymphadenopathy due to infectious mononucleosis: its confusion with malignant lym- phoma 显示文摘 | Salvador AH Harrison EG Kylc RA | 1971 | Cancer1971，27，5： | 1 |
| 7 | Endoplasmic reticulum stress and hy-pertension-a new paradigm显示文摘 | Hasty AH DG Harrison | 2012 | J Clin Invest2012，25，13： | 1 |
| 8 | Endoplasmic reticulum stress and hyper- tension -a new paradigm? 显示文摘 | Hasty AH Harrison DG | 2012 | J Clin Invest2012，122，11： | 1 |
| 9 | Nonalcoholic fatty liver disease 显示文摘 | Paredes AH Tortes DM Harrison SA | 2012 | Clin Liver Dis2012，16，2： | 1 |
| 10 | Tolerability of high-dose venlafaxineindepressiedpatients 显示文摘 | Harrison CL Ferrier N Young AH | 2004 | J Psychopharmacol2004，18，2： | 1 |
| 11 | Cell death in health and disease,the biology and regulation of apoptosis显示文摘 | Bellamy COC Malcomson RDG Harrison DJ Wyllie AH | 1995 | Sem Cancer Biol1995，6，： | 1 |
| 12 | The use of subtelomeric probes in preimplantation genetic diagnosis显示文摘 | Mackie-Ogilvie C Harrison RH Handyside AH | 1999 | J Med Genet1999，，： | 1 |
| 13 | Tolerability of high-dose venla- faxine in depressed patients显示文摘 | Harrison CL Ferrier N Young AH | 2004 | J Psychopharmacol2004，18，2： | 1 |
| 14 | Tolerability of high-dose venlafaxineindepressiedpatients显示文摘 | Harrison CL Ferrier N Young AH | 2004 | J Psychopharmacol2004，18，2： | 1 |
| 15 | Nonalcoholic fatty liver dis- ease显示文摘 | Paredes AH Tortes DM Harrison SA | 2012 | N Engl J Med2012，16，2： | 1 |
| 16 | Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil:a silver impregnation stud显示文摘 | Crain BJ Westerkam WD Harrison AH | 1988 | Neuroscience1988，27，： | 1 |
| 17 | Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil:a silver impregnation stud显示文摘 | Crain BJ Westerkam WD Harrison AH | 1988 | Neuroscience1988，27，： | 1 |
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